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Topic Review
Redundancy Principle
The redundancy principle in biology expresses the need of many copies of the same entity (cells, molecules, ions) to fulfill a biological function. Examples are numerous: disproportionate numbers of spermatozoa during fertilization compared to one egg, large number of neurotransmitters released during neuronal communication compared to the number of receptors, large numbers of released calcium ions during transient in cells and many more in molecular and cellular transduction or gene activation and cell signaling. This redundancy is particularly relevant when the sites of activation is physically separated from the initial position of the molecular messengers. The redundancy is often generated for the purpose of resolving the time constraint of fast-activating pathways. It can be expressed in terms of the theory of extreme statistics to determine its laws and quantify how shortest paths are selected. The main goal is to estimate these large numbers from physical principles and mathematical derivations. When large distance separate the source and the target (a small activation site), the redundancy principle explains that this geometrical gap can be compensated by large number. Had nature used less copies than normal, activation would have taken a much longer time, as finding a small target by chance is a rare events and falls into narrow escape problems.
  • 1.2K
  • 01 Dec 2022
Topic Review
Oxylipins in Inflammatory-Related Diseases NAFLD, Obesity, and T2D
Oxygenated polyunsaturated fatty acids (oxylipins) are bioactive molecules established as important mediators during inflammation. Different classes of oxylipins have been found to have opposite effects, e.g., pro-inflammatory prostaglandins and anti-inflammatory resolvins. Production of the different classes of oxylipins occurs during distinct stages of development and resolution of inflammation. Chronic inflammation is involved in the progression of many pathophysiological conditions and diseases such as non-alcoholic fatty liver disease, insulin resistance, diabetes, and obesity. Determining oxylipin profiles before, during, and after inflammatory-related diseases could provide clues to the onset, development, and prevention of detrimental conditions.
  • 1.2K
  • 19 Dec 2022
Topic Review
Anti-Inflammatory Effects of Taurine and Terpenes
Taurine, black pepper, and the major terpene constituents found in black pepper (i.e., β-caryophyllene; α-pinene; β-pinene; α-humulene; limonene; and sabinene) that are present in PhytoCann BP® have been shown to have cardioprotective effects based on anti-inflammatory, antioxidative, anti-hypertensive and anti-atherosclerotic mechanisms. 
  • 1.2K
  • 07 Jun 2023
Topic Review
Citrobacter sp. in Fish
Fish is considered a highly nutritious food that constitutes the human diet, produced through fishing and aquaculture activities, to be marketed and consumed around the world in different presentations and culinary preparations. Fish is also very susceptible to spoilage and contamination by microorganisms throughout the food chain, which may be part of the usual microbiota or incorporated into food derived from inadequate hygiene practices in the food industry. Fish has been associated worldwide with disease outbreaks derived from consumption, where various bacteria and/or metabolites (biogenic amines) are some of the main casual agents. Citrobacter sp. is considered a pathogen in fish, as well as in humans, derived from the consumption of contaminated food, generating infections or histamine poisoning as it is part of the generating microbiota.
  • 1.2K
  • 19 Jun 2023
Topic Review
Design Parameters of Power Amplifiers for Ultrasound Applications
A design analysis of the power amplifiers developed for ultrasound applications was conducted because ultrasound applications require different types of power amplifiers, which are one of the most critical electronic components in ultrasound systems. To generate acoustic signals using transducers, which are among the most important mechanical devices in ultrasound systems, an appropriate output voltage, current, or power signal must be produced by a power amplifier.
  • 1.2K
  • 11 Jul 2023
Topic Review
Driver Drowsiness Detection
Drowsy driving is a widespread cause of traffic accidents, especially on highways. It has become an essential task to seek an understanding of the situation in order to be able to take immediate remedial actions to detect driver drowsiness and enhance road safety.
  • 1.2K
  • 25 Sep 2023
Topic Review
Non Linear Current-Voltage Characteristics
The current-voltage (IV) curve of a solar photovoltaic (PV) array provides valuable insights into its behavior under varying conditions, including partial shading. Under normal, unshaded conditions, the IV curve depicts a characteristic shape where the current increases linearly with voltage until it reaches a peak known as the maximum power point (MPP). 
  • 1.2K
  • 16 Oct 2023
Topic Review
Fornax
Fornax, Latin for "furnace," is a small and faint constellation located in the southern celestial hemisphere. Despite its modest size, Fornax is home to several notable deep-sky objects, including the Fornax Cluster of galaxies. French astronomer Nicolas Louis de Lacaille bestowed the name "Fornax" upon this constellation in 1756, and it is now recognized as one of the 88 modern constellations.
  • 1.2K
  • 15 Mar 2024
Topic Review
O. Henry
O. Henry (William Sydney Porter, b. September 11, 1862 – d. June 5, 1910) was a celebrated American author best known for his more than 600 short stories characterized by humor, sentimentality, and unexpected endings. Writing during the early 20th century, he became a defining voice in popular fiction, with notable works such as “The Gift of the Magi,” “The Last Leaf,” and “The Cop and the Anthem.” His stories often explored the lives of ordinary people in New York City and beyond.
  • 1.2K
  • 16 May 2025
Topic Review
Electrochemical Sensing Platform for Methylen
Methylene blue is a toxic dye that is extensively used as a colorant in textile industries. Industrial effluent containing methylene blue, when drained into water bodies without proper treatment, poses a serious threat to aquatic and human lives. In order to protect the biocycle, various methods have been established to detect and remove hazardous dyes from aqueous systems. Electrochemical methods are preferred, owing to their characteristic features of simplicity, portability, potential selectivity, cost effectiveness, and rapid responsiveness. 
  • 1.2K
  • 07 Mar 2023
Topic Review
Role of Glutathione in Food and Human Diseases
Glutathione is a naturally occurring compound that plays a crucial role in the cellular response to oxidative stress through its ability to quench free radicals, thus mitigating the risk of potential damage, including cell death. While glutathione is endogenously present in different plants and animal cells, their concentration varies considerably. The alteration in glutathione homeostasis can be used as a potential marker for human diseases. In the case of the depletion of endogenous glutathione, exogenous sources can be used to replenish the pool. To this end, both natural and synthetic glutathione can be used. 
  • 1.2K
  • 13 Apr 2023
Topic Review
WO3 and Ionic Liquids -1
Although only recently ILs started to be used to enhance the performances of metal oxides based electrochemical gas sensors (with reference, in particular, to WO3 based sensors), the recognition of their role has been clearly asserted. In fact, not only ILs heavily influence the structure of WO3 nanoparticles when used in the synthetic step (nanoplates, nanorods, nanospheres, etc.), but their residues eventually present on nanoparticles surface can improve the sensed gas adsorption, thus yielding better performances. 
  • 1.2K
  • 29 Oct 2020
Topic Review
Monoubiquitin Signaling in Genetic Diseases
Ubiquitination is a reversible post-translational modification that controls protein function and stability. Different types of ubiquitination were described including polyubiquitination, the attachment of multiple ubiquitin residues, or monoubiquitination, the attachment of a single ubiquitin molecule. While most of the studies have described the role of polyubiquitination, recent evidences show that monoubiquitination is a key regulator of different cellular processes, including vesicular trafficking and protein complex formation and degradation. Enzymes regulating monoubiquitination such as E2 conjugating enzymes, E3 ligases or ubiquitin hydrolases, are found altered in several genetic diseases, including Parkinson's disease or Noonan syndrome.
  • 1.2K
  • 29 Oct 2020
Topic Review
Ground Level Isoprenoid Exchanges
The emissions of isoprenoids, a kind of biogenic volatile organic compounds (BVOCs), from soils is not well characterized. We quantified the exchange of isoprenoids between soil with litter and atmosphere along a horizontal gradient from the trunks of the trees, in a Mediterranean Pinus pinea plantation with dry and green needle litter to open herbaceous turf during mornings at mid-summer. Further, potential associated drivers were identified. Isoprenoid emissions were greatest and most diverse, and also can be roughly estimated by litter dry weight near the trunk, where the needle litter was denser. The composition of emitted isoprenoid by needle litter was different than the composition previously described for green needles. Low exchange rates of isoprenoids were recorded in open turf. Isoprenoid exchange rates were correlated positively with soil temperature and negatively with soil moisture. Given the variations in ground emissions with soil, vegetation, microorganisms, and associated interactions, we recommend widespread extensive spatio-temporal analysis of ground level BVOC exchanges in the different ecosystem types.
  • 1.2K
  • 07 Aug 2020
Topic Review
Population Projections
Population projections serve various actors at sub-national, national, and international levels as a quantitative basis for political and economic decision-making. Often, the users are no experts in statistics or forecasting and therefore lack the methodological and demographic background to completely understand the methods and limitations behind the projections they use for their analyses. Our contribution primarily targets that readership.
  • 1.2K
  • 27 Oct 2020
Topic Review
Inflammatory Bowel Diseases (Salivary Biomarkers)
Saliva as a biological fluid has a remarkable potential in the non-invasive diagnostics of several systemic disorders. Inflammatory bowel diseases are chronic inflammatory disorders of the gastrointestinal tract. 
  • 1.2K
  • 15 Oct 2020
Topic Review
Gluten Free Diet for IBS
The Gluten Free Diet is often considered as a diet therapy for Irritable Bowel Syndrome (IBS) patients, in addition to the more famous and recognized Low FODMAP Diet. Evidence on its efficacy and long-term safety is scarce, but it can still be included in therapy for selected IBS patients, on the basis of specific symptoms and dietary history.
  • 1.2K
  • 23 Nov 2020
Topic Review
Nemaline Myopathy
Nemaline myopathy is a disorder that primarily affects skeletal muscles, which are muscles that the body uses for movement. People with nemaline myopathy have muscle weakness (myopathy) throughout the body, but it is typically most severe in the muscles of the face; neck; trunk; and other muscles close to the center of the body (proximal muscles), such as those of the upper arms and legs.
  • 1.2K
  • 23 Dec 2020
Topic Review
Sheldon-Hall Syndrome
Sheldon-Hall syndrome, also known as distal arthrogryposis type 2B, is a disorder characterized by joint deformities (contractures) that restrict movement in the hands and feet.
  • 1.2K
  • 25 Dec 2020
Topic Review
Tumor-Associated Antigen xCT
The cystine/glutamate antiporter xCT is a tumor-associated antigen that has been newly identified in many cancer types. By participating in glutathione biosynthesis, xCT protects cancer cells from oxidative stress conditions and ferroptosis, and contributes to metabolic reprogramming, thus promoting tumor progression and chemoresistance. Moreover, xCT is overexpressed in cancer stem cells. These features render xCT a promising target for cancer therapy, as has been widely reported in the literature and in our work on its immunotargeting. Interestingly, studies on the TP53 gene have revealed that both wild-type and mutant p53 induce the post-transcriptional down-modulation of xCT, contributing to ferroptosis. Moreover, APR-246, a small molecule drug that can restore wild-type p53 function in cancer cells, has been described as an indirect modulator of xCT expression in tumors with mutant p53 accumulation and is thus a promising drug to use in combination with xCT inhibition.
  • 1.2K
  • 14 Jan 2021
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