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Topic Review
HLA-B Gene
Major histocompatibility complex, class I, B
  • 704
  • 22 Dec 2020
Topic Review
WDR35 Gene
WD repeat domain 35.
  • 704
  • 24 Dec 2020
Topic Review
Aloysia Citrodora Essential Oil
Patients diagnosed with melanoma have a poor prognosis due to regional invasion and metastases. The receptor tyrosine kinase epidermal growth factor receptor (EGFR) is found in a subtype of melanoma with a poor prognosis and contributes to drug resistance. Aloysia citrodora essential oil (ALOC-EO) possesses an antitumor effect. Understanding signaling pathways that contribute to the antitumor of ALOC-EO is important to identify novel tumor types that can be targeted by ALOC-EO. 
  • 704
  • 20 Aug 2021
Topic Review
RFX5 Gene
regulatory factor X5
  • 703
  • 24 Dec 2020
Topic Review
CDH23 Gene
cadherin related 23
  • 703
  • 24 Dec 2020
Topic Review
SCNN1G Gene
sodium channel epithelial 1 gamma subunit
  • 703
  • 24 Dec 2020
Topic Review
Transcription–Replication Coordination
Transcription and replication are the two most essential processes that a cell does with its DNA: they allow cells to express the genomic content that is required for their functions and to create a perfect copy of this genomic information to pass on to the daughter cells. Nevertheless, these two processes are in a constant ambivalent relationship. When transcription and replication occupy the same regions, there is the possibility of conflicts between transcription and replication as transcription can impair DNA replication progression leading to increased DNA damage. Nevertheless, DNA replication origins are preferentially located in open chromatin next to actively transcribed regions, meaning that the possibility of conflicts is potentially an accepted incident for cells. Data in the literature point both towards the existence or not of coordination between these two processes to avoid the danger of collisions.
  • 703
  • 27 Jan 2022
Topic Review
KANK2 Gene
KN motif and ankyrin repeat domains 2
  • 702
  • 23 Dec 2020
Topic Review
Nonketotic Hyperglycinemia
Nonketotic hyperglycinemia is a disorder characterized by abnormally high levels of a molecule called glycine in the body (hyperglycinemia). The excess glycine builds up in tissues and organs, particularly the brain. Affected individuals have serious neurological problems.
  • 702
  • 24 Dec 2020
Topic Review
Beta-Ketothiolase Deficiency
Beta-ketothiolase deficiency is an inherited disorder in which the body cannot effectively process a protein building block (amino acid) called isoleucine. This disorder also impairs the body's ability to process ketones, which are molecules produced during the breakdown of fats.
  • 702
  • 24 Dec 2020
Topic Review
CLCNKA Gene
chloride voltage-gated channel Ka
  • 702
  • 24 Dec 2020
Topic Review
ITGB4 Gene
Integrin subunit beta 4
  • 701
  • 23 Dec 2020
Topic Review
LMNB1 Gene
Lamin B1
  • 701
  • 23 Dec 2020
Topic Review
HNF1A Gene
HNF1 homeobox A
  • 700
  • 23 Dec 2020
Topic Review
ANKH Gene
ANKH inorganic pyrophosphate transport regulator
  • 700
  • 24 Dec 2020
Topic Review
DNMT1 Gene
DNA Methyltransferase 1: The DNMT1 gene provides instructions for making an enzyme called DNA methyltransferase 1. 
  • 700
  • 24 Dec 2020
Topic Review
CEP57 Gene
centrosomal protein 57
  • 700
  • 24 Dec 2020
Topic Review
Multiple Epiphyseal Dysplasia
Multiple epiphyseal dysplasia is a disorder of cartilage and bone development primarily affecting the ends of the long bones in the arms and legs (epiphyses). There are two types of multiple epiphyseal dysplasia, which can be distinguished by their pattern of inheritance. Both the dominant and recessive types have relatively mild signs and symptoms, including joint pain that most commonly affects the hips and knees, early-onset arthritis, and a waddling walk. Although some people with multiple epiphyseal dysplasia have mild short stature as adults, most are of normal height. The majority of individuals are diagnosed during childhood; however, some mild cases may not be diagnosed until adulthood.
  • 700
  • 23 Dec 2020
Topic Review
HNF4A Gene
Hepatocyte nuclear factor 4 alpha
  • 699
  • 23 Dec 2020
Topic Review
ATP6V0A2 Gene
ATPase H+ transporting V0 subunit a2
  • 699
  • 24 Dec 2020
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