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Topic Review
Cline
In biology, a cline (from the Greek κλίνειν klinein, meaning "to lean") is a measurable gradient in a single character (or biological trait) of a species across its geographical range. First coined by Julian Huxley in 1938, the "character" of the cline referred to is usually genetic (e.g. allele frequency, blood type), or phenotypic (e.g. body size, skin pigmentation). Clines can show smooth, continuous gradation in a character, or they may show more abrupt changes in the trait from one geographic region to the next. A cline refers to a spatial gradient in a specific, singular trait, rather than a collection of traits; a single population can therefore have as many clines as it has traits, at least in principle. Additionally, Huxley recognised that these multiple independent clines may not act in concordance with each other. For example, it has been observed that in Australia, birds generally become smaller the further towards the north of the country they are found. In contrast, the intensity of their plumage colouration follows a different geographical trajectory, being most vibrant where humidity is highest and becoming less vibrant further into the arid centre of the country. Because of this, clines were defined by Huxley as being an "auxiliary taxonomic principle"; that is, clinal variation in a species is not awarded taxonomic recognition in the way subspecies or species are. While the terms "ecotype" and "cline" are sometimes used interchangeably, they do in fact differ in that "ecotype" refers to a population which differs from other populations in a number of characters, rather than the single character that varies amongst populations in a cline.
  • 5.6K
  • 09 Nov 2022
Topic Review
LAV (Armoured Vehicle)
The Light Armoured Vehicle (LAV) is a series of armoured vehicles built by General Dynamics Land Systems – Canada (GDLS-C), a London, Ontario-based subsidiary of General Dynamics. It is a license-produced version of the Mowag Piranha. The LAV family came about from the Armoured Vehicle General Purpose (AVGP) requirement of the Canadian Army. The first generation of LAV was created by Mowag for the Armoured Vehicle General Purpose (AVGP) requirement of the Canadian Army. This was a 6x6 variant of the Piranha I produced by General Motors Diesel in London, Ontario. Since entering service in 1976, it has undergone a number of upgrades. The LAV II introduced the now-familiar 8x8 configuration. The LAV continues to form the backbone of the Canadian Army's combat vehicle fleet. The LAV series of vehicles exist in a number of different variants and are used in a number of different roles such as armoured personnel carriers, engineering vehicles, command posts, ambulances and armoured recovery vehicles.
  • 5.6K
  • 21 Nov 2022
Topic Review
White Privilege
White privilege, or white skin privilege, is the societal privilege that benefits white people over non-white people in some societies, particularly if they are otherwise under the same social, political, or economic circumstances. With roots in European colonialism and imperialism, and the Atlantic slave trade, white privilege has developed in circumstances that have broadly sought to protect white racial privileges, various national citizenships, and other rights or special benefits. In the study of white privilege and its broader field of whiteness studies, both pioneered in the United States , academic perspectives such as critical race theory use the concept to analyze how racism and racialized societies affect the lives of white or white-skinned people. For example, American academic Peggy McIntosh described the advantages that whites in Western societies enjoy and non-whites do not experience as "an invisible package of unearned assets". White privilege denotes both obvious and less obvious passive advantages that white people may not recognize they have, which distinguishes it from overt bias or prejudice. These include cultural affirmations of one's own worth; presumed greater social status; and freedom to move, buy, work, play, and speak freely. The effects can be seen in professional, educational, and personal contexts. The concept of white privilege also implies the right to assume the universality of one's own experiences, marking others as different or exceptional while perceiving oneself as normal. Some scholars say that the term uses the concept of "whiteness" as a proxy for class or other social privilege or as a distraction from deeper underlying problems of inequality. Others state that it is not that whiteness is a proxy but that many other social privileges are interconnected with it, requiring complex and careful analysis to identify how whiteness contributes to privilege. Other commentators propose alternative definitions of whiteness and exceptions to or limits of white identity, arguing that the concept of white privilege ignores important differences between white subpopulations and individuals and suggesting that the notion of whiteness cannot be inclusive of all white people. They note the problem of acknowledging the diversity of people of color and ethnicity within these groups. Some commentators have observed that the "academic-sounding concept of white privilege" sometimes elicits defensiveness and misunderstanding among white people, in part due to how the concept of white privilege was rapidly brought into the mainstream spotlight through social media campaigns such as Black Lives Matter. As an academic concept that was only recently brought into the mainstream, the concept of white privilege is frequently misinterpreted by non-academics; some academics, having studied white privilege undisturbed for decades, have been surprised by the seemingly sudden hostility from right-wing critics since approximately 2014.
  • 5.6K
  • 14 Oct 2022
Topic Review
Election Threshold
The electoral threshold is the minimum share of the primary vote which a candidate or political party requires to achieve before they become entitled to any representation in a legislature. This limit can operate in various ways. For example, in party-list proportional representation systems, an election threshold requires that a party must receive a specified minimum percentage of votes (e.g., 5%), either nationally or in a particular electoral district, to obtain any seats in the legislature. In multi-member constituencies using preferential voting, besides the electoral threshold, to be awarded a seat, a candidate is also required to achieve a quota, either on the primary vote or after distribution of preferences, which depends on the number of members to be return from a constituency. The effect of an electoral threshold is to deny representation to small parties or to force them into coalitions, with the presumption of rendering the election system more stable by keeping out fringe parties. However, critics argue out that in the absence of a ranked ballot system, supporters of minor parties are effectively disenfranchised and denied the right of representation by someone of their choosing. Two boundaries can be defined: a threshold of representation is the minimum vote share that might yield a party a seat (under the most favorable circumstances for the party), while the threshold of exclusion is the maximum vote share that could be insufficient to yield a seat (under the least favorable circumstances). Lijphart suggested calculating the informal threshold as the mean of these.
  • 5.6K
  • 11 Nov 2022
Topic Review
Protein Quality Control (PQC)
Eukaryotic cells have a well-organized, tightly regulated protein quality control (PQC) system. This quality control system includes the molecular chaperones, ubiquitin/proteasome-dependent protein degradation, and autophagy machinery (target and uptake of non-native conformer in the spatial compartments) that consistently monitors and maintains the conformational state of cellular proteins.
  • 5.6K
  • 18 Mar 2021
Topic Review
Policy Evolution of Chinese New Energy Vehicle Industry
The Chinese new energy vehicle industry policy is divided into three development periods: 2004–2008—promotion policy and technological policy; 2009–2013—financial policy; and 2014–2020—charging infrastructure policy. 
  • 5.6K
  • 29 Jun 2022
Topic Review
Immune Response to SARS-CoV-2 and mRNA Vaccines
The SARS-CoV-2 (severe acute respiratory syndrome coronavirus responsible for the COVID-19 disease) uses the Spike proteins of its envelope for infecting target cells expressing on the membrane the angiotensin converting enzyme 2 (ACE2) enzyme that acts as a receptor. To control the pandemic, genetically engineered vaccines have been designed for inducing neutralizing antibodies against the Spike proteins. These vaccines do not act like traditional protein-based vaccines, as they deliver the message in the form of mRNA or DNA to host cells that then produce and expose the Spike protein on the membrane (from which it can be shed in soluble form) to alert the immune system. Since the genetically engineered vaccines have been modified to be more stable and because they are distributed via liponanoparticles to various tissues and organs, this type of products may cause unforeseen serious adverse effects.
  • 5.6K
  • 19 Apr 2023
Topic Review
MAPK Pathways in Cancer Metastasis
Metastasis is perhaps the most common reason for treatment failure in cancer patients, as well as the leading cause of cancer-related death. Mitogen-activated protein kinase (MAPK) are serine/threonine-protein kinases that can be activated by a variety of extracellular stimuli including growth factors, cytokines, insulin, environmental factors, and oxidative and genotoxic stress. It is becoming increasingly clear that MAPKs are involved in all the steps required for hyperproliferating cells to develop into metastatic tumors. However, scholars are currently lacking in vivo data to fully understand how MAPK signaling pathways can affect the progression of metastatic disease. 
  • 5.6K
  • 26 May 2022
Topic Review
Gudjonsson Suggestibility Scale
The Gudjonsson suggestibility scale (GSS) is a psychological test that measures suggestibility of a subject. It was created in 1983 by Icelandic psychologist Gísli Hannes Guðjónsson. It involves reading a short story to the subject and testing recall. This test has been used in court cases in several jurisdictions but has been the subject of various criticisms.
  • 5.6K
  • 03 Nov 2022
Topic Review
Application of Google Earth Engine
Google Earth Engine (GEE) is a cloud computing platform that was launched by Google in 2010. Since then, GEE has demonstrated its capacity of preprocessing and mining of geographic big data. GEE enables cloud computation and is an effective tool for carrying out the analysis of global geospatial big data.
  • 5.6K
  • 08 Oct 2021
Topic Review
49,XXXXY Syndrome
49,XXXXY syndrome is a chromosomal condition in boys and men that causes intellectual disability, developmental delays, physical differences, and an inability to father biological children (infertility). Its signs and symptoms vary among affected individuals.
  • 5.6K
  • 23 Dec 2020
Topic Review
Satellitosis in Neurological Disease
The secondary structures of Scherer commonly known as perineuronal and perivascular satellitosis have been identified as a histopathological hallmark of diffuse, invasive, high-grade gliomas. They are recognised as perineuronal satellitosis when clusters of neoplastic glial cells surround neurons cell bodies and perivascular satellitosis when such tumour cells surround blood vessels infiltrating Virchow–Robin spaces. 
  • 5.6K
  • 27 Jan 2021
Topic Review
Birch Plywood
Increasing demand pressures on the fibre supply are forcing manufacturers to explore using new species in plywood. Here authors investigated aspen and black alder, alone and in combination with birch faces, and with different veneer thicknesses in plywood production.
  • 5.6K
  • 09 Feb 2022
Topic Review
Coastal Structures in Malaysia
The shoreline of Malaysia is exposed to threats of coastal erosion and a rise of sea level. The National Coastal Erosion Study, 2015 reported that 15% of an 8840 km shoreline is currently eroding, where one-third of those falls under the critical and significant categories that require structural protection. The Study of Sea Level Rise in Malaysia, 2017 presented a sea-level increase of 0.67–0.74 mm on average yearly.  
  • 5.6K
  • 05 Jul 2021
Topic Review
Formal Methods for Artificial Intelligence: Opportunities and Challenges
The use of formal approaches in machine learning is becoming increasingly crucial as ML systems are utilized in more critical applications such as autonomous driving and medical diagnosis. Formal methods give a rigorous approach to evaluating the accuracy and reliability of ML systems, which is critical for ensuring their safety and efficacy. Formal approaches, which use mathematical models and logic-based reasoning, can assist discover and eliminate flaws and vulnerabilities in ML systems, lowering the risk of unintended effects and boosting overall performance. As a result, using formal approaches is vital for developing trustworthy ML systems that can be depended on in safety-sensitive applications.
  • 5.6K
  • 22 May 2023
Topic Review
Winemaking By-products
The winemaking by-products and waste, such as wine lees, grape stalks, and vine shoots, are generated from vinification process and after pruning. For their high content in functional and bioactive compounds, they can be recycled into food chain as functional additives to improve the quality of wines and to obtain innovative functional foods and sustainable food packaging, contributing to the sustainability of the wine sector.
  • 5.6K
  • 04 Mar 2021
Topic Review
Dysgraphia
Dysgraphia is a learning disability of written expression, that affects the ability to write, primarily handwriting, but also coherence. It is a specific learning disability (SLD) as well as a transcription disability, meaning that it is a writing disorder associated with impaired handwriting, orthographic coding and finger sequencing (the movement of muscles required to write). It often overlaps with other learning disabilities and neurodevelopmental disorders such as speech impairment, attention deficit hyperactivity disorder (ADHD) or developmental coordination disorder (DCD). In the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV), dysgraphia is characterized as a learning disability in the category of written expression, when one's writing skills are below those expected given a person's age measured through intelligence and age-appropriate education. The DSM is unclear in whether writing refers only to the motor skills involved in writing, or if it also includes orthographic skills and spelling. Dysgraphia should be distinguished from agraphia (sometimes called acquired dysgraphia), which is an acquired loss of the ability to write resulting from brain injury, progressive illness, or a stroke. The prevalence of dysgraphia throughout the world is not known, due to difficulties in diagnosis and lack of research.
  • 5.6K
  • 10 Nov 2022
Topic Review
Google Street View
Google Street View is a technology featured in Google Maps and Google Earth that provides interactive panoramas from positions along many streets in the world. It was launched in 2007 in several cities in the United States, and has since expanded to include cities and rural areas worldwide. Streets with Street View imagery available are shown as blue lines on Google Maps. Google Street View displays interactively panoramas of stitched VR photographs. Most photography is done by car, but some is done by tricycle, camel, boat, snowmobile, underwater apparatus, and on foot.
  • 5.6K
  • 28 Sep 2022
Topic Review
List of Methods of Torture
A list of torture methods and devices includes:
  • 5.6K
  • 19 Oct 2022
Topic Review Peer Reviewed
Tourism Destination Marketing: Academic Knowledge
A holistic, multi-organization view of marketing or destination management organizations (DMOs) who must muster the best efforts of many partner organizations and individuals (stakeholders) to have the greatest success. Destination marketing is described as “a continuous, sequential process through which a DMO plans, researches, implements, controls and evaluates programs aimed at satisfying tourists’ needs and wants as well as the destination’s and DMO’s visions, goals and objectives”. The effectiveness of marketing activities depends on the efforts and plans of tourism suppliers and other entities. This definition posits that marketing is a managerial function/domain that should be performed in a systematic manner adopting and implementing the appropriate approaches, as well as suitable tools and methods. In doing so, it is believed that a tourism destination (through the organizational structure of a DMO) can attain the expected outputs beneficial to all stakeholders, i.e., the tourism industry, hosting communities/populations, and tourists/visitors. The effective implementation of tourism destination marketing principles and methods constitutes an efficient and smart pillar, a cornerstone to attain a balance/equilibrium between the perceptions and interests, sometimes conflicting, of stakeholders by minimizing the negative impacts and maximizing the benefits resulting from tourism. All the same, it is worth noting that marketing is not a panacea, nor a kind of magic stick. 
  • 5.5K
  • 13 Apr 2022
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