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Topic Review
Application of CZT Detector in Nuclear Detection
CdZnTe (CZT) is a new type of compound semiconductor. Compared to other semiconductor materials, it possesses an ideal bandgap, high density, and high electron mobility, rendering it an excellent room-temperature composite semiconductor material for X-ray and γ-ray detectors. Due to the exceptional performance of CZT material, detectors manufactured using it exhibit high energy resolution, spatial resolution, and detection efficiency. They also have the advantage of operating at room temperature. CZT array detectors, furthermore, demonstrate outstanding spatial detection and three-dimensional imaging capabilities.
  • 1.4K
  • 26 Feb 2024
Topic Review
Antlia
Antlia is a constellation recognized by the International Astronomical Union (IAU), situated in the southern celestial hemisphere. Named after the air pump, it is a relatively faint constellation with no stars brighter than fourth magnitude, but it contains several interesting deep-sky objects, including the Antlia Galaxy Cluster, making it a fascinating subject for exploration by astronomers.
  • 1.4K
  • 15 Mar 2024
Topic Review
Allosteric Drug Discovery
Understanding molecular mechanisms underlying the complexity of allosteric regulation in proteins has attracted considerable attention in drug discovery due to the benefits and versatility of allosteric modulators in providing desirable selectivity against protein targets while minimizing toxicity and other side effects. The proliferation of novel computational approaches for predicting ligand–protein interactions and binding using dynamic and network-centric perspectives has led to new insights into allosteric mechanisms and facilitated computer-based discovery of allosteric drugs. Although no absolute method of experimental and in silico allosteric drug/site discovery exists, current methods are still being improved. As such, the critical analysis and integration of established approaches into robust, reproducible, and customizable computational pipelines with experimental feedback could make allosteric drug discovery more efficient and reliable. In this article, we review computational approaches for allosteric drug discovery and discuss how these tools can be utilized to develop consensus workflows for in silico identification of allosteric sites and modulators with some applications to pathogen resistance and precision medicine. The emerging realization that allosteric modulators can exploit distinct regulatory mechanisms and can provide access to targeted modulation of protein activities could open opportunities for probing biological processes and in silico design of drug combinations with improved therapeutic indices and a broad range of activities.
  • 1.4K
  • 26 Sep 2021
Topic Review
Avian Pathogenic Escherichia coli
Avian pathogenic E. coli (APEC) are the major etiology of avian colibacillosis. Unlike other pathogenic E. coli, APEC causes extra-intestinal infections. Here we focus on the first time detection of APEC from layer farms in Bangladesh using molecular based approach targeting specific APEC associated virulence genes. In addition, their antibiotic resistance profile were also evaluated. Surprisingly all the isolates were found MDR in nature which is very alarming from public health point of view because of their zoonotic potentiality.
  • 1.4K
  • 27 Oct 2020
Topic Review
Anthocyanin Bioactivity in Obesity
Obesity and type-2 diabetes trends continue to worsen in the United States. Dietary anthocyanins (typically provided by berries and other fruits) are reported to have protective effects against both conditions using a variety of experimental research models including animal and human feeding studies. This review highlights studies that explore the biochemical pathways in both tissue and rodent models which could explain clinical improvements noted with anthocyanin consumption. First, the primary mode of intestinal absorption of anthocyanins is through both sGLT1 and GLUT2 glucose transporters. Stronger binding affinities may allow anthocyanins to be more inhibitive to glucose absorption compared to the reverse, where GLUT2 expression may also be affected. Genetic or chemical inhibition of sGLT1 or GLUT2 demonstrate their essential function in anthocyanin absorption across the enterocyte, where the former interacts with a greater variety of anthocyanins but the latter is the major transporter for specific anthocyanin-glycosides. Once absorbed, anthocyanins positively modulate GLUT4 density and function in both skeletal muscle and adipose tissues via the upregulation of AMPK and restoration of insulin sensitivity. Antioxidant properties and phosphodiesterase inhibition by anthocyanins promote both mitochondrial function and density which could be novel targets for dietary management of obesity and its complications.
  • 1.4K
  • 01 Dec 2020
Topic Review
Temozolomide Use in IDH-Mutant Gliomas
In this entry, we discuss the use of the alkylating agent temozolomide (TMZ) in the treatment of IDH-mutant gliomas. We describe the challenges associated with TMZ in clinical (drug resistance and tumor recurrence) and preclinical settings (variabilities associated with in vitro models) in treating IDH-mutant glioma.
  • 1.4K
  • 03 Jun 2021
Topic Review
SR-B1 in Cardiovascular Disease
The scavenger receptor B class type 1 (SR-B1) was identified as the high-affinity HDL receptor, which facilitates the selective uptake of cholesterol ester (CE) into the liver via HDL and is also implicated in the plasma clearance of LDL, very low-density lipoprotein (VLDL) and lipoprotein(a) (Lp(a)). Thus, SR-B1 is a multifunctional receptor that plays a main role in the metabolism of different lipoproteins. 
  • 1.4K
  • 03 Jun 2021
Topic Review
Alpha-Synuclein
Alpha-Synuclein (α-syn) has strong connection with Parkinson’s disease. Parkinson’s disease (PD) is considered the most common disorder of synucleinopathy, which is characterised by intracellular inclusions of aggregated and misfolded α-syn protein in various brain regions, and the loss of dopaminergic neurons. During the early prodromal phase of PD, synaptic alterations happen before cell death, which is linked to the synaptic accumulation of toxic α-syn specifically in the presynaptic terminals, affecting neurotransmitter release. The oligomers and protofibrils of α-syn are the most toxic species, and their overexpression impairs the distribution and activation of synaptic proteins, such as the SNARE complex, preventing neurotransmitter exocytosis and neuronal synaptic communication. In the last few years, the role of the immune system in PD has been increasingly considered. Microglial and astrocyte activation, the gene expression of proinflammatory factors, and the infiltration of immune cells from the periphery to the central nervous system (CNS) represent the main features of the inflammatory response. One of the actors of these processes is α-syn accumulation.
  • 1.4K
  • 29 Jun 2021
Topic Review
Wound Healing
Wound healing is a multistage dynamic process including haemostasis, inflammation, cell proliferation and tissue remodelling.
  • 1.4K
  • 09 Jul 2021
Topic Review
Sex Differences in Dopamine Receptors
Dopamine is an important neurotransmitter that plays a key role in neuropsychiatric illness.
  • 1.4K
  • 28 Sep 2021
Topic Review
Safety Issues Buckling Steel Structures Improving Historical Methods
Buckling of structural elements is a phenomenon that has great consequences on the bearing capacity of structures. Historically, there have been serious buckling-related structural accidents that have resulted in loss of human lives and high material costs. 
  • 1.4K
  • 28 Mar 2022
Topic Review
Milk Production in OECD Countries
Since the beginning of the industrialization of the dairy cattle sector (1950s), driven by the need to feed the rapidly growing urban areas, this industry has experienced several improvements, evolving in management and technology. These changes have been felt above all in the terms of milking, rearing, nutrition, reproductive management, and design of facilities. Shortage of labor, emphasis on increasing farm efficiency, and quality of life of the farmers were the driving factors for these changes. To achieve it, in many areas of the world, pasture production has been abandoned, moving to indoor production, which allows for greater nutritional and reproductive control of the animals. To keep pace with this paradigm in milk production, animal health management has also been improved. Prevention and biosecurity have become essential to control and prevent pathologies that cause great economic losses. As such, veterinary herd health management programs were created, allowing the management of health of the herd as a whole, through the common work of veterinarians and farmers.
  • 1.4K
  • 21 Mar 2022
Topic Review
Types of Scaffolds in Cartilage Regeneration
There are two main types of scaffolds: natural polymers and synthetic polymers. On the one hand, natural polymers are proteins (e.g., collagen, SF) and polysaccharides (e.g., Alg, CS, and HA derivatives). Natural polymers already have a long history of application in wound treatment. They are the closest substances to human tissue and show biocompatibility and biodegradability without toxic byproducts, and their technologies and properties have been widely investigated. Furthermore, in the form of hydrogels, they can retain a great amount of water. However, natural polymers are normally poor in mechanical strength. On the other hand, synthetic polymers have different properties. They allow the better control of formation, surface morphology, mechanical strength and physicochemical properties than natural polymers. Among them, poly(lactic acid) (PLA), poly(glycolic acid) (PGA), poly(lactic-co-glycolic acid) (PLGA), poly(ε-caprolactone) (PCL) and poly(urethanes) (PU) are the most popular candidates in osteochondral regeneration. The limitations of synthetic polymers are poor hydrophilicity, proinflammatory degradation byproducts, and unmatched degradation rates. It is noticeable that these two types of polymers are not independent.
  • 1.4K
  • 08 Sep 2022
Topic Review
Role of Proteins and Divalent Ions in LLPS
Liquid–liquid phase separation (LLPS) is one of the key mechanisms affecting how macromolecular assemblies, including membrane-less organelles (MLOs), are formed and regulated. The molecular and biochemical mechanisms involved in the biomineralization pathway remain puzzling. Additionally, the significance of intrinsically disordered proteins (IDPs), which are an abundant organic component of hard tissues, in the formation of liquid precursors of biominerals remains to be solved. Research on the interactions between proteins and divalent cations is essential for understanding the resulting liquid precursors.
  • 1.4K
  • 21 Sep 2022
Topic Review
Crowdsourcing Public Engagement for Urban Planning
Crowdsourcing could potentially have great benefits for the development of sustainable cities in the Global South (GS), where a growing population and rapid urbanization represent serious challenges for the years to come.
  • 1.4K
  • 23 Sep 2022
Topic Review
Restraining Order
A restraining order or protective order is an order used by a court to protect a person, business, company, establishment, or entity, and the general public, in a situation involving alleged domestic violence, harassment, stalking, or sexual assault. In the United States , every state has some form of domestic violence restraining order law, and many states also have specific restraining order laws for stalking and sexual assault. Restraining and personal protection order laws vary from one jurisdiction to another but all establish who can file for an order, what protection or relief a person can get from such an order, and how the order will be enforced. The court will order the adverse party to refrain from certain actions or require compliance with certain provisions. Failure to comply is a violation of the order which can result in the arrest and prosecution of the offender. Violations in some jurisdictions may also constitute criminal or civil contempt of court.
  • 1.4K
  • 08 Nov 2022
Topic Review
Proactive Contracting
Proactive Contracting is akin to Proactive Law and focuses on the same properties, namely to prevent problems and promote relationships. The legal area of research developed in Scandinavia in the 1990s and has gradually gained attention. Proactive Contracting deals with Contract Management, Relational Management, Risk Management and Business Process Management. The word proactive is the opposition to reactive and refers to acting in anticipation of future problems, needs, or changes. A survey conducted by IACCM shows that businesses urge a paradigm shift in contracting, favoring a more relational approach. Thus, the focus of future contracting becomes more relational. Businesses may therefore face increased complexity as trading is done not only across physical boundaries, but also across religious, cultural, and ethical boundaries. The IACCM survey has underpinned the need for re-thinking contracts and the approach to business relationships, as international, and long relationships, make it hard to draft and agree upon every single event that might occur in the future. Proactive Contracting is moving away from the path of responding to these complex relationships with complex contracts. However, as it is hard to imagine realistic alternatives to contracts, Proactive Contracting suggest businesses to change perception of contracts to meet the needs of the future. Add to this the increased complexity of products due to technological evolution and it becomes clear that businesses need to actively deal with the danger of increasing complexity and uncertainty. In fact, a survey conducted by IBM Corporation revealed that 79% of Chief Executive Officers (CEOs) see increased global complexity as a major challenge over the coming years. As the legal framework increases in complexity, it becomes apparent that there is a need for creating certainty in order to support future trading. Businesses need to manage this complexity in order to avoid unnecessary losses, but also in order to exploit all the possibilities deriving from global interaction. Empirical studies on contracting capabilities and research on dynamic capabilities have shown that promoting proactive behavior in businesses is a key in the quest of future success. As globalization increases, sustainability and certainty become more urgent, resulting in decentralization of the traditional legal environment. The reason for this decentralization is that the traditional legal environment does not fulfill the task of creating the certainty and sustainability that businesses need in order to prosper. After the launch of the United Nations Decade of Education for Sustainable Development, mechanisms have evolved through which future development is achieved. According to these mechanisms, a sound development must be focusing on ethically acceptable, morally fair and economically sound processes. Management tools for global value chains have already been developed, and focus is especially on self- and private regulation instruments and standards - this is where proactive contracting and proactive law is coming to the fore.
  • 1.4K
  • 08 Nov 2022
Topic Review
Climate Change Policy of California
California has taken legislative steps in the hope of mitigating the risks of potential effects of climate change in California by incentives and plans for clean cars, renewable energy, and pollution controls on industry.
  • 1.4K
  • 01 Dec 2022
Topic Review
Types of Fiber Optic Sensors
In the upcoming space revolutions aiming at the implementation of automated, smart, and self-aware crewless vehicles and reusable spacecraft, sensors play a significant role in the control systems. In particular, fiber optic sensors, with their small footprint and electromagnetic immunity, represent a great opportunity for aerospace applications. 
  • 1.4K
  • 09 Mar 2023
Topic Review
Structural Testing of Tidal Turbine Blades
Structural testing of tidal turbine blades is vital due to several reasons. Firstly, it allows for the optimization of blade performance, ensuring efficient energy conversion and maximizing power output. Secondly, it ensures the reliability and safety of the blades, enabling them to withstand harsh marine conditions and reducing the risk of failure or damage. Thirdly, structural testing helps assess the durability of the blades, determining their fatigue life and enabling effective maintenance strategies. Additionally, it aids in designing cost-effective solutions by evaluating materials, manufacturing techniques, and configurations. Finally, structural testing facilitates regulatory compliance, ensuring that blades meet the necessary standards and certifications for deployment in tidal energy projects. Overall, structural testing plays a crucial role in enhancing performance, safety, durability, cost-effectiveness, and regulatory compliance of tidal turbine blades.
  • 1.4K
  • 03 Jul 2023
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