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Peng, Y. Ribosome Shunting. Encyclopedia. Available online: https://encyclopedia.pub/entry/60959 (accessed on 02 November 2026).
Peng Y. Ribosome Shunting. Encyclopedia. Available at: https://encyclopedia.pub/entry/60959. Accessed November 02, 2026.
Peng, Yu. "Ribosome Shunting" Encyclopedia, https://encyclopedia.pub/entry/60959 (accessed November 02, 2026).
Peng, Y. (2026, October 14). Ribosome Shunting. In Encyclopedia. https://encyclopedia.pub/entry/60959
Peng, Yu. "Ribosome Shunting." Encyclopedia. Web. 14 October, 2026.
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Ribosome Shunting
EditRibosome shunting is a translation-initiation mechanism in which a ribosomal complex bypasses an internal portion of a messenger-RNA leader and reaches a downstream initiation region. In characterized plant viral leaders, sequences near the two ends support translation while much of the intervening region can be omitted from the ribosome's path [1]. Contacts between ribosomal RNA and messenger RNA can contribute to recruitment or positioning during such noncanonical initiation events [2]. Some shunting arrangements are cap-dependent and use a leader element complementary to 18S ribosomal RNA to promote downstream translation [3][4]. Other arrangements couple translation of a short upstream open reading frame to subsequent bypass of a structured RNA segment. The retained ribosomal complex then reinitiates at a downstream coding region [5].
translation initiation
ribosomal scanning
upstream open reading frame
mRNA leader
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References
- Waltraud Schmidt-Puchta; Diana Dominguez; Diana Lewetag; Thomas Hohn; Plant Ribosome Shunting in Vitro. Nucleic Acids Res. 1997, 25, 2854-2860. [CrossRef]
- Franck Martin; Jean-François Ménétret; Angelita Simonetti; Alexander G. Myasnikov; Quentin Vicens; Lydia Prongidi-Fix; S. Kundhavai Natchiar; Bruno P. Klaholz; Gilbert Eriani; Ribosomal 18S rRNA Base Pairs with mRNA during Eukaryotic Translation Initiation. Nat. Commun. 2016, 7, 1-7. [CrossRef]
- Stephen A. Chappell; John Dresios; Gerald M. Edelman; Vincent P. Mauro; Ribosomal Shunting Mediated by a Translational Enhancer Element that Base Pairs to 18S rRNA. Proc. Natl. Acad. Sci. 2006, 103, 9488-9493. [CrossRef]
- T. Racine; R. Duncan; Facilitated Leaky Scanning and Atypical Ribosome Shunting Direct Downstream Translation Initiation on the Tricistronic S1 mRNA of Avian Reovirus. Nucleic Acids Res. 2010, 38, 7260-7272. [CrossRef]
- Lyubov A Ryabova; Mikhail M Pooggin; Thomas Hohn. Viral Strategies of Translation Initiation: Ribosomal Shunt and Reinitiation; Elsevier: Amsterdam, NX, Netherlands, 2002; pp. 1-39. [CrossRef]
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Biochemistry & Molecular Biology
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