Submitted Successfully!
To reward your contribution, here is a gift for you: A free trial for our video production service.
Thank you for your contribution! You can also upload a video entry or images related to this topic.
Version Summary Created by Modification Content Size Created at Operation
1 + 308 word(s) 308 2020-12-29 15:10:04 |
2 Roll back entry to make some changes. + 97 word(s) 405 2020-12-30 02:36:07 |

Video Upload Options

Do you have a full video?

Confirm

Are you sure to Delete?
Cite
If you have any further questions, please contact Encyclopedia Editorial Office.
Suzuki, Y. SARS-CoV-2 spike protein. Encyclopedia. Available online: https://encyclopedia.pub/entry/5895 (accessed on 21 April 2024).
Suzuki Y. SARS-CoV-2 spike protein. Encyclopedia. Available at: https://encyclopedia.pub/entry/5895. Accessed April 21, 2024.
Suzuki, Yuichiro. "SARS-CoV-2 spike protein" Encyclopedia, https://encyclopedia.pub/entry/5895 (accessed April 21, 2024).
Suzuki, Y. (2020, December 29). SARS-CoV-2 spike protein. In Encyclopedia. https://encyclopedia.pub/entry/5895
Suzuki, Yuichiro. "SARS-CoV-2 spike protein." Encyclopedia. Web. 29 December, 2020.
SARS-CoV-2 spike protein
Edit

The article by Suresh & Suzuki (2021) describes the finding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein affecting human lung vascular cells and explains how the spike protein possibly increases the incidence of pulmonary arterial hypertension (PAH). Since the SARS-CoV-2 spike protein will be administered to millions of people as vaccines, it is critical to understand the effects of this protein on human cells to ensure that it does not promote long-term adverse health consequences.

cell signaling coronavirus COVID-19 lung pulmonary hypertension SARS-CoV-2 spike protein vaccine vascular viral membrane fusion protein

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is causing the current pandemic of coronavirus disease 2019 (COVID-19). SARS-CoV-2 uses its viral membrane fusion protein, the spike protein, to enter the host cells. COVID-19 vaccines introduce the SARS-CoV-2 spike protein into the human body to acquire immunity.

The article by Suresh & Suzuki [1] describes the finding of the SARS-CoV-2 spike protein affecting human lung vascular cells and explains how the spike protein possibly increases the incidence of pulmonary arterial hypertension (PAH).

In addition to facilitating the membrane fusion and viral entry, the SARS-CoV-2 spike protein (without the rest of the viral components) promotes cell growth signaling in human lung vascular cells [2]. Patients who died of COVID-19 have been shown to exhibit thickened pulmonary vascular walls [2]. Lung vascular cell growth and vascular wall thickening are pathogenic features of PAH, a fatal disease that can affect people of any age.

Like the SARS-CoV-2 spike protein, gp120, the viral membrane fusion protein of HIV, has also been reported to promote cell signaling. Long-term surviving HIV-positive patients are known to have a high incidence of developing PAH.

Thus, viruses whose viral membrane fusion proteins elicit cell signaling are linked to PAH.

Further experimentation and careful clinical observations for PAH in relation to SARS-CoV-2 infection and COVID-19 vaccines are thus warranted. Since the SARS-CoV-2 spike protein will be administered to millions of people as vaccines, it is critical to understand the effects of this protein on human cells to ensure that it does not promote long-term adverse health consequences.

 

REFERENCES

[1] Suresh, S.J.; Suzuki, Y.J. SARS-CoV-2 spike protein and lung vascular cells.  J. Respir. 2021, 1, 40-48; https://doi.org/10.3390/jor1010004

[2] Suzuki, Y.J.; Nikolaienko, S.I.; Dibrova, V.A.; Dibrova, Y.V.; Vasylyk, V.M.; Novikov, M.Y.; Shults, N.V.; Gychka, S.G. SARS-CoV-2 spike protein-mediated cell signaling in lung vascular cells. Vascul. Pharmacol. 2020; https://doi.org/10.1016/j.vph.2020.106823

 

 

 

 

Information
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register :
View Times: 568
Revisions: 2 times (View History)
Update Date: 06 Jan 2021
1000/1000