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Xu, R. Progressive Supranuclear Palsy. Encyclopedia. Available online: https://encyclopedia.pub/entry/5486 (accessed on 25 September 2026).
Xu R. Progressive Supranuclear Palsy. Encyclopedia. Available at: https://encyclopedia.pub/entry/5486. Accessed September 25, 2026.
Xu, Rita. "Progressive Supranuclear Palsy" Encyclopedia, https://encyclopedia.pub/entry/5486 (accessed September 25, 2026).
Xu, R. (2020, December 24). Progressive Supranuclear Palsy. In Encyclopedia. https://encyclopedia.pub/entry/5486
Xu, Rita. "Progressive Supranuclear Palsy." Encyclopedia. Web. 24 December, 2020.
Progressive Supranuclear Palsy
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This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/condition/progressive-supranuclear-palsy

Progressive supranuclear palsy is a brain disorder that affects movement, vision, speech, and thinking ability (cognition). The signs and symptoms of this disorder usually become apparent in mid- to late adulthood, most often in a person's 60s. Most people with progressive supranuclear palsy survive 5 to 9 years after the disease first appears, although a few affected individuals have lived for more than a decade.

genetic conditions

References

  1. Conrad C, Andreadis A, Trojanowski JQ, Dickson DW, Kang D, Chen X, Wiederholt W, Hansen L, Masliah E, Thal LJ, Katzman R, Xia Y, Saitoh T. Genetic evidence forthe involvement of tau in progressive supranuclear palsy. Ann Neurol. 1997Feb;41(2):277-81.
  2. Donker Kaat L, Boon AJ, Azmani A, Kamphorst W, Breteler MM, Anar B, Heutink P,van Swieten JC. Familial aggregation of parkinsonism in progressive supranuclear palsy. Neurology. 2009 Jul 14;73(2):98-105. doi: 10.1212/WNL.0b013e3181a92bcc.
  3. Ferrari R, Ryten M, Simone R, Trabzuni D, Nicolaou N, Hondhamuni G, RamasamyA, Vandrovcova J; UK Brain Expression Consortium, Weale ME, Lees AJ, Momeni P,Hardy J, de Silva R. Assessment of common variability and expression quantitativetrait loci for genome-wide associations for progressive supranuclear palsy.Neurobiol Aging. 2014 Jun;35(6):1514.e1-12. doi:10.1016/j.neurobiolaging.2014.01.010.Aging. 2015 Nov;36(11):3118. Nicolaou, Naiya [Corrected to Nicolaou, Nayia].Neurobiol Aging. 2015 Nov;36(11):3118.
  4. Golbe LI. Progressive supranuclear palsy. Semin Neurol. 2014 Apr;34(2):151-9. doi: 10.1055/s-0034-1381736.
  5. Höglinger GU, Melhem NM, Dickson DW, Sleiman PM, Wang LS, Klei L, RademakersR, de Silva R, Litvan I, Riley DE, van Swieten JC, Heutink P, Wszolek ZK, UittiRJ, Vandrovcova J, Hurtig HI, Gross RG, Maetzler W, Goldwurm S, Tolosa E, BorroniB, Pastor P; PSP Genetics Study Group, Cantwell LB, Han MR, Dillman A, van derBrug MP, Gibbs JR, Cookson MR, Hernandez DG, Singleton AB, Farrer MJ, Yu CE,Golbe LI, Revesz T, Hardy J, Lees AJ, Devlin B, Hakonarson H, Müller U,Schellenberg GD. Identification of common variants influencing risk of thetauopathy progressive supranuclear palsy. Nat Genet. 2011 Jun 19;43(7):699-705.doi: 10.1038/ng.859.
  6. Melquist S, Craig DW, Huentelman MJ, Crook R, Pearson JV, Baker M, Zismann VL,Gass J, Adamson J, Szelinger S, Corneveaux J, Cannon A, Coon KD, Lincoln S, AdlerC, Tuite P, Calne DB, Bigio EH, Uitti RJ, Wszolek ZK, Golbe LI, Caselli RJ,Graff-Radford N, Litvan I, Farrer MJ, Dickson DW, Hutton M, Stephan DA.Identification of a novel risk locus for progressive supranuclear palsy by apooled genomewide scan of 500,288 single-nucleotide polymorphisms. Am J HumGenet. 2007 Apr;80(4):769-78.
  7. Williams DR, Lees AJ. Progressive supranuclear palsy: clinicopathologicalconcepts and diagnostic challenges. Lancet Neurol. 2009 Mar;8(3):270-9. doi:10.1016/S1474-4422(09)70042-0. Review.
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Subjects: Genetics & Heredity
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Rita Xu
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Update Date: 24 Dec 2020
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