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Tzanova, M.; Atanasov, V.; Yaneva, Z.; Ivanova, D.; Dinev, T. Flavonoids—Classification and Natural Sources. Encyclopedia. Available online: https://encyclopedia.pub/entry/2767 (accessed on 21 November 2024).
Tzanova M, Atanasov V, Yaneva Z, Ivanova D, Dinev T. Flavonoids—Classification and Natural Sources. Encyclopedia. Available at: https://encyclopedia.pub/entry/2767. Accessed November 21, 2024.
Tzanova, Milena, Vasil Atanasov, Zvezdelina Yaneva, Donika Ivanova, Toncho Dinev. "Flavonoids—Classification and Natural Sources" Encyclopedia, https://encyclopedia.pub/entry/2767 (accessed November 21, 2024).
Tzanova, M., Atanasov, V., Yaneva, Z., Ivanova, D., & Dinev, T. (2020, October 23). Flavonoids—Classification and Natural Sources. In Encyclopedia. https://encyclopedia.pub/entry/2767
Tzanova, Milena, et al. "Flavonoids—Classification and Natural Sources." Encyclopedia. Web. 23 October, 2020.
Flavonoids—Classification and Natural Sources
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This entry is adapted from the peer-reviewed paper 10.3390/pr8101222

       Flavonoids are small molecules, produced de novo by plants as secondary metabolites in response to diverse biotic and abiotic factors. These chemical compounds have a broad spectrum of established health-promoting effects. They are due to their antioxidative, anti-inflammatory, anti-mutagenic, and anti-carcinogenic properties coupled with their capacity to modulate key cellular enzyme functions. Flavonoids are widely distributed chemical compounds in the plant kingdom. Plants are therefore an inexhaustible source of flavonoids.

flavonoids natural sources

1. Flavonoids—Classification

       The flavonoid family includes more than 6000 low-molecular-weight phenolic compounds [1], derivatives of flavan. The main subgroups are flavones, flavonols, flavonones, flavononols, flavan-3-ols, anthocyanines, isoflavones, and chalcones (Figure 1).

Figure 1. Structures of flavonoid subgroups.

       The flavan core is recognized in every single flavonoid structure. It consists of 15 carbon atoms which build two aromatic rings (commonly denoted as A and B) linked by a three-carbon chain. The connecting carbon chain is a part of a heterocyclic central ring (designed as C) and is available in the most flavonoids with one exception: in the structure of the chalcones the carbon chain between the A and B rings is linear [2]. For that reason the chalcones can be referred to as open-chain flavonoids.

       Depending on the position of the linked B-ring to the benzopyrano (called also chromano) structure the flavones, flavonols, flavonones, flavononols, flavon-3-ols and anthocyanines, are 2-phenylbenzopyrans and the isoflavonoids are 3-phynylbenzopyrans, which makes this structures positional isomers. The flavonoids of the 2-phenylbenzopyran-subgroup differ in the degree of oxidation and saturation of the heterocyclic C-ring [3].

2. Natural Sources of Flavonoids

       Flavonoids are small molecules, produced de novo by plants as secondary metabolites in response to diverse biotic and abiotic factors. They are widely distributed chemical compounds in the plant kingdom. Plants are therefore an inexhaustible source of flavonoids.

       In 1936, the Hungarian scientist Szent-Gyorgyi (the discoverer of vitamin C) isolated a new substance from lemons. He called it “citrin” [3]. The structure of citrin was determined later: it is composed of the flavonoids hesperidin and eriodictyol [4]. Citrin was called also vitamin P. But, in 1950 was concluded that flavonoids did not meet the strict definition of a vitamin and the name vitamin P was taken off [5].

       Their biochemical roles of the flavonoids in the plant are multifarious: from flower pigmentation to taking part in the growing processes, and the defense against diseases [6]. Each flavonoid group plays a unique biochemical role and has a particular distribution in plants [3].

       The most popular edible plants rich in flavonoids, categorized by Tzanova et al. [7] in subgroups, are systematized in Tables 1.

Table 1. Food plants rich in flavonoids

Flavonoid subgroup

Flavonoids

Food

References

 

Flavonols

and

Flavan-3-ols

Kaempferol; quercetin; myrecitin; (−)-epicatechin

Black berries; wine

 

[8][9][10]

Kaempferol; quercetin

Tomato

[11][12]

 

(+)-Catechin;

(−)-epicatechin; epigallocatechin; chrysin; apigenin; quercetin; kaempferol

Tea

[13][14][15]

 

(+)-Catechin;

(−)-epicatechin; quercetin

Coffee; cocoa; apple

[9][16][17][18][19][20]

 

Kaempferol; quercetin; myricetin; tamarixetin

Onion; red wine; olive oil; berries; grapefruit; orange

[21][22]

 

(+)-Catechin;

(−)-epicatechin; quercetin; kaempferol

Red berries; strawberries

[9][23][24][25]

 

Quercetin

Lemon;

olive; aspargus

[22][26][27]

 

Kaempferol

Saffron spice

[28]

 

Kaempferol; quercetin

Broccoli; brussel sprouts

[15][18]

 

(+)-Catechin;

(−)-epicatechin

Apricot; nectarine; peach; plum; fig; banana; kiwi; hazelnut

[9][10][29][30][31]

 

(+)-Catechin;

(−)-epicatechin; quercetin; isorhamnetin; kaempferol

Almond

[31][32]

 

Flavones

Luteolin

Fruit skins; red wine; buckwheat; red pepper; tomato skin;

lemon; watermelon; brussel sprouts; pumpkin

[22][31][33][34]

  
 

Luteolin; apigenin; isorhoifolin

Olive

[26][35]

 

Flavonones

Naringin; eriodictyol

Almond

[32]

 

Naringin; maringenin; taxifolin; hesperitin; eriodictyol

Citrus fruits; grapefruit; lemon; orange

[22][36][37]

 

Anthocyanins

Apigenidin; cyanidin

Cherry; easberry; strawberry

[21][22][25]

 

Cyanidin

Olive

[26][35]

 

Isoflavones

Daidzin; genistein; glycitin; sissotrin; ononin

Soya bean

[38][39][40][41]

 

Biochanin A; formononetin

Red clover

[41]

 

Genistin; daidzin; biochanin A

Peanut

[42]

 

       Fruits and vegetables are a rich diet source of flavonols and flavan-3-ols. Kaempferol, quercetin and myricetin are most studied flavonols, and catechin and epicatechin – the most studied flavan-3-ols. Because of their similar solubility in the polar alcoholic solvents, flavonols and flavan-3-ols were simultaneously extracted and detected, e.g. in black berries and wines [8][9][10]; in red berries [9][23][24]; in tee [13][15]; or coffee [9][16][17][18][19][20]. Onions, tomatoes, broccoli, apples and grapes are rich sources of flavonols [21][22].

       Flavones are widely present in leaves, flowers and fruits as glucosides and their major sources are green leafy spices like parsley [43]. Luteolin is the most found flavone [22][26][31][32][33][34][35].

       Flavanones are generally present in all citrus fruits [22][36][37]. Hesperitin, naringenin and eriodictyol are examples of this class of flavonoids. These compounds are responsible for the bitter taste of the juice and peel of citrus fruits. Almonds are rich also in naringin and eriodictyol [32].

       Anthocyanins are pigments responsible for the coloring of flowers and fruits. Cyanidin is the most commonly studied anthocyanin. Various red and blue fruits are a rich diet sources of anthocyanins, which are concentrated in the fruit skins [21][22][25][26][35].

       Isoflavones are found in legumes predominantly, e.g. soybean [38][39][40][41], but also in red clover [41] and in peanuts [42].

       Major examples of chalcones include phloridzin, arbutin, phloretin, and chalconaringenin. Chalcones occur in significant amounts in tomatoes, pears, strawberries, bearberries, and certain wheat products [43].

       Tzanova et al. [7] systemized the flavonoids detected in medicinal plants rich in their subgroups (Table 2).

Table 2. Medicinal plants rich in flavonoids

Flavonoid subgroup

Flavonoids

Medicinal Plant (Family)

References

 

Flavonols

and

Flavan-ols

(+)-Catechin

Brysonima crassa (Compositae)

[44]

 

Isorhamnetin

Calendula officinalis (Compositae)

[45]

 

Kaempferol

Acalypha indica (Euphorbiaceae);

Clitoria ternatea (Fabaceae);

Pteris vittata L (‎Pteridaceae)

[46][47][48]

 

Quercetin

Betula pendula (Betulaceae)

Bauhinia monandra (Fabaceae);

Pteris vittata L (‎Pteridaceae)

Cannabis sativa (Compositae);

Azadirachta indica (Meliaceae);

Angelica L. (Apiaceae);

[45][48][49][50][51]

 

Hyperoside

Tilia cordata (Tiliaceae)

[45]

 

Isoquercetin

Mimosa pudica (Mimosoideae)

[52]

 

Pongaflavonol

Pongamia pinnata (Fabaceae)

[53]

 

2-(3, 4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one

Chenopodium album L. (Chenopodiaceae)

[54]

 

2-(3,4-dihydroxy-5-methoxy-phenyl)-3,5-dihydroxy-6,7-dimethoxychromen-4-one

Euphorbia neriifolia (Euphorbiaceae)

[55]

 

Flavones

Pectolinarigenin

Clerodendrum phlomidis (Verbenaceae)

[49]

 

Luteolin

Aloe vera (Asphodelaceae);

Momordica charantia (Curcurbitaceae);

Bacopa moneirra (Scrophulariaceae);

Angelica L. (Apiaceae);

Mentha longifolia (Lamiaceae)

[46][50][56][57]

 

Hispidulin; apigenin; cirsimaritin

Rosmarinus officinalis L. (Lamiaceae)

[58][59]

 

Luteolin; hispidulin; apigenin; cirsimaritin

Salvia officinalis L. (Lamiaceae)

[58]

 

Luteolin; hispidulin

Thymus L. (Lamiaceae)

[58][60]

 

Apigenin; hispidulin

Verbena officinalis L. (Verbenaceae)

[60]

 

5-hydroxy-7,8-dimethoxyflavone

Andrographis paniculata (Acanthaceae)

[45]

 

3,4-methlenedioxyflavone

Limnophila indica (Scrophulariaceae)

[52]

 

Chrysin

Oroxylum indicum (Bignoniaceaea)

[52]

 

Vitexin

Passiflora incarnate (Passifloraceae)

[45]

 

Flavonones

Narginin

Rosmarinus officinalis L. (Lamiaceae)

[58][59]

 

Hesperidin

Citrus medica (Rutaceae)

[46]

 

Liquiritin

Glyccheriza glabra (Leguminosae)

[45]

 

Kurarinol;

kurarinone

Sophora flavescens Ait. (Fabaceae)

[61]

 

Flavononols

Kushenol I;

kushenol N

Sophora flavescens Ait. (Fabaceae)

[61]

 

Isoflavones

Genistein

Calopogonium muconoides (Fabaceae)

Butea monospermea (Fabaceae);

Andira macrothyrsa (Fabaceae);

[41]

[51]

  
 

Biochanin A

Cratylia argentea (Fabaceae);

A. macrothyrsa (Melastomataceae)

[41]

 

 

       Among the medicinal plants the Fabaceae family are mostly investigated: flavonoles are found in Bauhinia monandra [45], Clitoria ternatea [47], and Pongamia pinnata [53]; flavonones and flavononols – in Sophora flavescens Ait [51]. Best represented are of course the isoflavones – in Calopogonium muconoides, Butea monospermea, Andira macrothyrsa, and Cratylia argentea [41][51].

       Lamiaceae family is also good presented: plants from this family are rich source of flavones and flavonones, for example Rosmarinus officinalis L. [58][59]. From other members of this family are isolated flavones: Salvia officinalis L. [58], Thymus L. [58][60], and Mentha longifolia [57]. Flavonoles and flavones are the wide distributed in the medicinal plants flavonoids, just like in the food plants.

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Subjects: Materials Science, Biomaterials
Contributors MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register :
Milena Tzanova
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Vasil Atanasov
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Zvezdelina Yaneva
,
Donika Ivanova
,
Toncho Dinev
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