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The progress in wearable chemosensors is presented with attention drawn to the measuring technologies, their ability to provide robust data, the manufacturing techniques, as well their autonomy and ability to produce power. However, from statistical studies, the issue of patients’ trust in these technologies has arisen. People do not trust their personal data be transferred, stored, and processed through the vastness of the internet, which allows for timely diagnosis and treatment. The issue of power consumption and autonomy of chemosensor-integrated devices is also studied and the most recent solutions to this problem thoroughly presented.
2. Technical and Science Background
2.1. Model Structure of a Typical Chemosensor
2.2. Chemosensor Realization Technologies
2.3. Micro & Nano-Fabrication Techniques
2.4. 3D Printing
3. Body Fluids Used for Analysis
4. Energy Harvesting for Wearables
Catching up from the introductory reference to thermoelectric power generation via the Seebeck effect, some more effects come into play in this area. The thermoelectric effect
is the direct conversion of temperature difference to electric voltage and vice versa via a thermocouple. A thermoelectric device creates a voltage when there is a temperature gradient between the sides of the device.
However, promising thermoelectrics are capable of supplying power by converting body heat, but wearable thermoelectrics have not been as yet, capable of producing electrical power stable or high enough for supporting the uninterrupted operation of commercial types of health monitoring sensors. For this purpose, synergistic integration of a wearable thermoelectric generator (WTEG) and a new type of marketed Li-S battery on the basis of a commercial glucose sensor was proposed . The WTEG has delivered power in a stable and continuous mode, showing a path to overcome one of the biggest hurdles in fully applying thermoelectrics for wearable electronics in practice. As exhibited, the major disadvantage of low thermoelectric output voltage, hampering batteries’ charging, has been greatly alleviated by using the high-performance Li-S battery. The charging voltage of this battery is only half of the standard Li-ion batteries. The WTEG hybrid system was able to continuously produce power as much as 378 µW, operating a commercial glucose sensor (power consumption: 64 µW) and storing the surplus in the Li-S batteries for providing a stable continuous voltage of 2 V even under large fluctuations in power supply and consumption.
5. Conclusions and Future Perspectives
Although there has been significant progress in the last few years, there are still significant requirements such as power management, real-time communication, and biocompatibility that have to be addressed for the next generation of wearable chemosensors. The continuous demand for comprising multiple modalities in a sensor platform in combination with wireless communication services and data analytics increases the devices’ power requirements. Several strategies are applied to address the power management challenge, such as the implementation of energy harvesting techniques, the development of supercapacitors, and the fabrication of flexible and light-weight batteries; however, the device’s energy consumption remains one of the major problems facing existing wearable sensors.
Additionally, the real-time, continuous, and uninterrupted transmission of information to a wearer or a computer device is a significant aspect of wearable technology. Up to now, wearable sensor platforms exhibit data transmission capability via Bluetooth, NFC, and high-frequency passive RFID communication protocols. Nevertheless, these communication technologies demonstrate several drawbacks, mainly the compatibility with low-rate data. Researchers should investigate other types of wireless communication technologies that will be used in wearable applications, like optical wireless technologies, as well as develop advanced algorithms for the information’s transmission.
Furthermore, the sensor’s resistance to mechanical damages or the capability to be selfhealing is another issue that must be improved during subsequent years. The employed techniques are not sufficient to protect the sensor device from ordinary wear and tear, unanticipated damage, or unintended stain. Consequently, many efforts have been made for the development of devices that have the ability of self-healing (partially or completely) mimicking natural systems. The advancements in the field of nanomaterials give researchers the opportunity to fabricate such devices in order to improve their reliability and promote durability and lifespan.
Since wearable biosensor devices are highly desired for the real-time determination of a human’s health condition, as well as for elderly care and they are promising in terms of personalized medicine, it is crucial to amend their stability, reliability, safety, and biocompatibility in order to pass from test devices to their commercialization. The nanomaterials’ biocompatibility that comes into direct contact with the epidermis without
causing toxicity effects is essential to be considered in the design and development of wearable biosensors. Various factors such as the size, the shape, and the roughness of the materials placed on the epidermis, as well as their chemistry and degradation, could affect the biocompatibility of the sensor, although it is difficult to predict how exactly a material will behave when interacts with an individual. Regarding this matter, our knowledge, so far, is limited, and there must be further investigation for the development of biocompatible nanomaterials towards safe usage in wearables. According to flexible biosensor platforms, apart from the reliability of the noninvasive sampling of biofluids, another challenge that must be addressed is the interference that provokes several physiological factors, such as temperature, as well as the adhesion of the sensor to the epidermis. Additionally, the sampling frequency is one more factor that has to be investigated in detail since there must be a balance taking into consideration, on the one hand, the sampling rate and on the other hand, the energy consumption of the device. Hence, there must be an optimization between power management and sampling frequency. Additionally, a major issue arose from population research because the common person or patients still do not place their trust in these sensors for medical monitoring and timely treatment. Handling and security of (their) big data and personalized information is a significant issue that should be considered and confronted as early as possible.
However, we are optimistic about the high potential of wearable chemosensors technologies along with the advances in the Industry 4.0, IoT and all advances to come it can be foreseen that the lifestyle and quality of life and health shall improve in the coming years. Our speed to counteract pandemics and detect pathogens will improve and likewise personalized medicine and being alert to dangerous conditions of our health will considerably increase our abilities to the protection of human life.
This entry is adapted from 10.3390/chemosensors9050099
- Butler, P.J.; Osborne, M.P. The effect of cervical vagotomy (decentralization) on the ultrastructure of the carotid body of the duck, Anas platyrhynchos. Cell Tissue Res. 1975, 163, 491–502.
- Kim, J.; Khan, S.; Wu, P.; Park, S.; Park, H.; Yu, C.; Kim, W. Self-charging wearables for continuous health monitoring. Nano Energy 2021, 79, 105419.
- Li, Q.; Xia, Y.; Wan, X.; Yang, S.; Cai, Z.; Ye, Y.; Li, G. Morphology-dependent MnO2/nitrogen-doped graphene nanocomposites for simultaneous detection of trace dopamine and uric acid. Mater. Sci. Eng. C 2020, 109, 110615.
- Scarpa, E.; Mastronardi, V.M.; Guido, F.; Algieri, L.; Qualtieri, A.; Fiammengo, R.; Rizzi, F.; De Vittorio, M. Wearable piezoelectric mass sensor based on pH sensitive hydrogels for sweat pH monitoring. Sci. Rep. 2020, 10, 1–10.
- Bandodkar, A.J.; Hung, V.W.S.; Jia, W.; Valdés-Ramírez, G.; Windmiller, J.R.; Martinez, A.G.; Ramírez, J.; Chan, G.; Kerman, K.; Wang, J. Tattoo-based potentiometric ion-selective sensors for epidermal pH monitoring. Analyst 2013, 138, 123–128.
- Pal, A.; Nadiger, V.G.; Goswami, D.; Martinez, R.V. Conformal, waterproof electronic decals for wireless monitoring of sweat and vaginal pH at the point-of-care. Biosens. Bioelectron. 2020, 160, 112206.
- Vivaldi, F.; Salvo, P.; Poma, N.; Bonini, A.; Biagini, D.; Del Noce, L.; Melai, B.; Lisi, F.; Di Francesco, F. Recent Advances in Optical, Electrochemical and Field Effect pH Sensors. Chemosensors 2021, 9, 33.
- Giannetti, A.; Bocková, M. Optical chemosensors and biosensors. Chemosensors 2020, 8, 33.
- Tran, V.-T.; Riveros, C.; Ravaud, P. Patients’ views of wearable devices and AI in healthcare: Findings from the ComPaRe e-cohort. NPJ Digit. Med. 2019, 2, 1–8.
- Liu, E.; Negm, A.; Howlader, M.M.R. Thermoelectric generation via tellurene for wearable applications: Recent advances, research challenges, and future perspectives. Mater. Today Energy 2021, 20, 100625.
- Zhang, M.; Shi, J.; Liao, C.; Tian, Q.; Wang, C.; Chen, S.; Zang, L. Perylene imide-based optical chemosensors for vapor detection. Chemosensors 2021, 9, 1.
- Okur, S.; Sarheed, M.; Huber, R.; Zhang, Z.; Heinke, L.; Kanbar, A.; Wöll, C.; Nick, P.; Lemmer, U. Identification of Mint Scents Using a QCM Based E-Nose. Chemosensors 2021, 9, 31.
- Kim, J.; Campbell, A.S.; de Ávila, B.E.F.; Wang, J. Wearable biosensors for healthcare monitoring. Nat. Biotechnol. 2019, 37, 389–406.
- Bandodkar, A.J.; Wang, J. Non-invasive wearable electrochemical sensors: A review. Trends Biotechnol. 2014, 32, 363–371.
- Haghi, M.; Deserno, T.M. General conceptual framework of futurewearables in healthcare: Unified, unique, ubiquitous, and unobtrusive (U4) for customized quantified output. Chemosensors 2020, 8, 85.
- Qian, R.C.; Long, Y.T. Wearable Chemosensors: A Review of Recent Progress. Chem. Open 2018, 7, 118–130.
- Castano, L.M.; Flatau, A.B. Smart fabric sensors and e-textile technologies: A review. Smart Mater. Struct. 2014, 23.
- Toprakci, H.A.K.; Ghosh, T.K. Handbook of Smart Textiles. Handb. Smart Text. 2014, 1–19.
- Li, Z.; Ge, Z.; Tong, X.; Guo, L.; Huo, J.; Li, D.; Li, H.; Lu, A.; Li, T. Phosphorescent iridium(III) complexes bearing L-alanine ligands: Synthesis, crystal structures, photophysical properties, DFT calculations, and use as chemosensors for Cu2+ ion. Dye Pigment. 2021, 186, 109016.
- Awolusi, I.; Marks, E.; Hallowell, M. Wearable technology for personalized construction safety monitoring and trending: Review of applicable devices. Autom. Constr. 2018, 85, 96–106.
- Lim, S.; Son, D.; Kim, J.; Lee, Y.B.; Song, J.K.; Choi, S.; Lee, D.J.; Kim, J.H.; Lee, M.; Hyeon, T.; et al. Transparent and stretchable interactive human machine interface based on patterned graphene heterostructures. Adv. Funct. Mater. 2015, 25, 375–383.
- Brown, M.S.; Ashley, B.; Koh, A. Wearable technology for chronic wound monitoring: Current dressings, advancements, and future prospects. Front. Bioeng. Biotechnol. 2018, 6, 1–21.
- Bocchetta, P.; Frattini, D.; Ghosh, S.; Mohan, A.M.V.; Kumar, Y.; Kwon, Y. Soft materials for wearable/flexible electrochemical energy conversion, storage, and biosensor devices. Materials 2020, 13, 2733.
- Patel, S.; Park, H.; Bonato, P.; Chan, L.; Rodgers, M. A review of wearable sensors and systems with application in rehabilitation. J. Neuroeng. Rehabil. 2012, 21, 1–17.
- Xiong, J.; Cui, P.; Chen, X.; Wang, J.; Parida, K.; Lin, M.-F.; Lee, P.S. Skin-touch-actuated textile-based triboelectric nanogenerator with black phosphorus for durable biomechanical energy harvesting. Nat. Commun. 2018, 9, 4280.
- Li, G.; Mo, X.; Law, W.-C.; Chan, K.C. Wearable fluid capture devices for electrochemical sensing of sweat. ACS Appl. Mater. Interfaces 2018, 11, 238–243.
- Kabiri Ameri, S.; Ho, R.; Jang, H.; Tao, L.; Wang, Y.; Wang, L.; Schnyer, D.M.; Akinwande, D.; Lu, N. Graphene electronic tattoo sensors. ACS Nano 2017, 11, 7634–7641.
- Chen, X. Making Electrodes Stretchable. Small Methods 2017, 1, 1600029.
- Fattahi, P.; Yang, G.; Kim, G.; Abidian, M.R. A review of organic and inorganic biomaterials for neural interfaces. Adv. Mater. 2014, 26, 1846–1885.
- Qi, D.; Liu, Z.; Yu, M.; Liu, Y.; Tang, Y.; Lv, J.; Li, Y.; Wei, J.; Liedberg, B.; Yu, Z.; et al. Highly stretchable gold nanobelts with sinusoidal structures for recording electrocorticograms. Adv. Mater. 2015, 27, 3145–3151.
- He, Y.; Wu, Y.; Fu, J.Z.; Gao, Q.; Qiu, J.J. Developments of 3D Printing Microfluidics and Applications in Chemistry and Biology: A Review. Electroanalysis 2016, 28, 1658–1678.
- Li, S.; Ma, Z.; Cao, Z.; Pan, L.; Shi, Y. Advanced Wearable Microfluidic Sensors for Healthcare Monitoring. Small 2020, 16, 1–15.
- Mejía-Salazar, J.R.; Cruz, K.R.; Vásques, E.M.M.; de Oliveira, O.N. Microfluidic point-of-care devices: New trends and future prospects for ehealth diagnostics. Sensors 2020, 20, 1951.
- Agustini, D.; Fedalto, L.; Agustini, D.; de Matos dos Santos, L.G.; Banks, C.E.; Bergamini, M.F.; Marcolino-Junior, L.H. A low cost, versatile and chromatographic device for microfluidic amperometric analyses. Sens. Actuators B Chem. 2020, 304, 127117.
- Martín, A.; Kim, J.; Kurniawan, J.F.; Sempionatto, J.R.; Moreto, J.R.; Tang, G.; Campbell, A.S.; Shin, A.; Lee, M.Y.; Liu, X.; et al. Epidermal Microfluidic Electrochemical Detection System: Enhanced Sweat Sampling and Metabolite Detection. ACS Sens. 2017, 2, 1860–1868.
- Almbrok, E.M.; Yusof, N.A.; Abdullah, J.; Mohd Zawawi, R. Electrochemical Detection of a Local Anesthetic Dibucaine at Arrays of Liquid|LiquidMicroInterfaces. Chemosensors 2021, 9, 15.
- Hartwig, M.; Zichner, R.; Joseph, Y. Inkjet-printed wireless chemiresistive sensors-A review. Chemosensors 2018, 6, 66.
- Teymourian, H.; Parrilla, M.; Sempionatto, J.; Montiel, N.F.; Barfidokht, A.; Van Echelpoel, R.; De Wael, K.; Wang, J. Wearable Electrochemical Sensors for the Monitoring and Screening of Drugs. ACS Sens. 2020, 5, 2679–2700.
- Damiati, S.; Kompella, U.B.; Damiati, S.A.; Kodzius, R. Microfluidic devices for drug delivery systems and drug screening. Genes 2018, 9, 103.
- Pavesi, A.; Adriani, G.; Tay, A.; Warkiani, M.E.; Yeap, W.H.; Wong, S.C.; Kamm, R.D. Engineering a 3D microfluidic culture platform for tumor-treating field application. Sci. Rep. 2016, 6, 1–10.
- Su, Y.; Wang, J.; Wang, B.; Yang, T.; Yang, B.; Xie, G.; Zhou, Y.; Zhang, S.; Tai, H.; Cai, Z.; et al. Alveolus-Inspired Active Membrane Sensors for Self-Powered Wearable Chemical Sensing and Breath Analysis. ACS Nano 2020, 14, 6067–6075.
- Jiang, Y.; Shen, L.; Ma, J.; Ma, H.; Su, Y.; Zhu, N. Wearable Porous Au Smartsensors for On-Site Detection of Multiple Metal Ions. Anal. Chem. 2021.
- Zheng, Y.; He, Z.Z.; Yang, J.; Liu, J. Personal electronics printing via tapping mode composite liquid metal ink delivery and adhesion mechanism. Sci. Rep. 2014, 4, 1–8.
- Jiang, X.; Zhang, R.; Yang, T.; Lin, S.; Chen, Q.; Zhen, Z.; Xie, D.; Zhu, H. Foldable and electrically stable graphene film resistors prepared by vacuum filtration for flexible electronics. Surf. Coat. Technol. 2016, 299, 22–28.
- Tian, L.; Li, Y.; Webb, R.C.; Krishnan, S.; Bian, Z.; Song, J.; Ning, X.; Crawford, K.; Kurniawan, J.; Bonifas, A.; et al. Flexible and Stretchable 3ω Sensors for Thermal Characterization of Human Skin. Adv. Funct. Mater. 2017, 27, 1–9.
- Xu, B.; Akhtar, A.; Liu, Y.; Chen, H.; Yeo, W.H.; Park, S.; Boyce, B.; Kim, H.; Yu, J.; Lai, H.Y.; et al. An Epidermal Stimulation and Sensing Platform for Sensorimotor Prosthetic Control, Management of Lower Back Exertion, and Electrical Muscle Activation. Adv. Mater. 2016, 28, 4462–4471.
- Koralli, P.; Petropoulou, G.; Mouzakis, D.E.; Mousdis, G.K.M. Efficient CO sensing by a CuO: Au nanocomposite thin film deposited by PLD on a Pyrex tube. Sens. Actuators A Phys. 2021. submitted for publication.
- Sasaki, T.K.; Ikegami, A.; Mochizuki, M.; Aoki, N.; Ochiai, Y. Transport measurements of DNA molecules by using carbon nanotube nano-electrodes. AIP Conf. Proc. 2005, 772, 1091–1092.
- Wilhelmi, O.; Reyntjens, S.; Van Leer, B.; Anzalone, P.A.; Giannuzzi, L.A. Focused Ion and Electron Beam Techniques; Elsevier Inc.: Amsterdam, The Netherlands, 2010; ISBN 9780815515944.
- Parmenter, C.D.; Nizamudeen, Z.A. Cryo-FIB-lift-out: Practically impossible to practical reality. J. Microsc. 2021, 281, 157–174.
- Lee, J.S.; Hill, R.T.; Chilkoti, A.; Murphy, W.L. Surface Patterning, 4th ed.; Elsevier: Amsterdam, The Netherlands, 2020.
- Liu, N.; Ye, X.; Yao, B.; Zhao, M.; Wu, P.; Liu, G.; Zhuang, D.; Jiang, H.; Chen, X.; He, Y.; et al. Advances in 3D bioprinting technology for cardiac tissue engineering and regeneration. Bioact. Mater. 2021, 6, 1388–1401.
- Shan, B.; Broza, Y.Y.; Li, W.; Wang, Y.; Wu, S.; Liu, Z.; Wang, J.; Gui, S.; Wang, L.; Zhang, Z.; et al. Multiplexed Nanomaterial-Based Sensor Array for Detection of COVID-19 in Exhaled Breath. ACS Nano 2020, 14, 12125–12132.
- Erdem, Ö.; Derin, E.; Sagdic, K.; Yilmaz, E.G.; Inci, F. Smart materials-integrated sensor technologies for COVID-19 diagnosis. Emerg. Mater. 2021.
- Tong, A.; Sorrell, T.; Black, A.; Caillaud, C.; Chrzanowski, W.; Li, E.; Martinez-Martin, D.; McEwan, A.; Wang, R.; Motion, A.; et al. Research priorities for COVID-19 sensor technology. Nat. Biotechnol. 2021, 39, 144–147.
- de Araujo Andreotti, I.A.; Orzari, L.O.; Camargo, J.R.; Faria, R.C.; Marcolino-Junior, L.H.; Bergamini, M.F.; Gatti, A.; Janegitz, B.C. Disposable and flexible electrochemical sensor made by recyclable material and low cost conductive ink. J. Electroanal. Chem. 2019, 840, 109–116.
- Pradela-Filho, L.A.; Araújo, D.A.G.; Takeuchi, R.M.; Santos, A.L. Nail polish and carbon powder: An attractive mixture to prepare paper-based electrodes. Electrochim. Acta 2017, 258, 786–792.
- Manzanares Palenzuela, C.L.; Pumera, M. (Bio)Analytical chemistry enabled by 3D printing: Sensors and biosensors. TrAC Trends Anal. Chem. 2018, 103, 110–118.
- Zhang, C.; Bills, B.J.; Manicke, N.E. Rapid prototyping using 3D printing in bioanalytical research. Bioanalysis 2017, 9, 329–331.
- Goole, J.; Amighi, K. 3D printing in pharmaceutics: A new tool for designing customized drug delivery systems. Int. J. Pharm. 2016, 499, 376–394.
- Ford, S.; Despeisse, M. Additive manufacturing and sustainability: An exploratory study of the advantages and challenges. J. Clean. Prod. 2016, 137, 1573–1587.
- Choudhary, H.; Vaithiyanathan, D.; Kumar, H. A Review on Additive Manufactured Sensors. Mapan J. Metrol. Soc. India 2020.
- Ho, C.M.B.; Ng, S.H.; Li, K.H.H.; Yoon, Y.J. 3D printed microfluidics for biological applications. Lab Chip 2015, 15, 3627–3637.
- Gowers, S.A.N.; Curto, V.F.; Seneci, C.A.; Wang, C.; Anastasova, S.; Vadgama, P.; Yang, G.Z.; Boutelle, M.G. 3D Printed Microfluidic Device with Integrated Biosensors for Online Analysis of Subcutaneous Human Microdialysate. Anal. Chem. 2015, 87, 7763–7770.
- Katseli, V.; Economou, A.; Kokkinos, C. Smartphone-Addressable 3D-Printed Electrochemical Ring for Nonenzymatic Self-Monitoring of Glucose in Human Sweat. Anal. Chem. 2021.
- Elsherif, M.; Hassan, M.U.; Yetisen, A.K.; Butt, H. Wearable Contact Lens Biosensors for Continuous Glucose Monitoring Using Smartphones. ACS Nano 2018, 12, 5452–5462.
- Yeh, P.C.; Chen, J.; Karakurt, I.; Lin, L. 3D Printed Bio-Sensing Chip for the Determination of Bacteria Antibiotic-Resistant Profile. In Proceedings of the 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII (TRANSDUCERS 2019 and EUROSENSORS XXXIII), Berlin, Germany, 23–27 June 2019; IEEE: Berlin, Germany, 2019; pp. 126–129.
- Kam, W.; Mohammed, W.S.; O’Keeffe, S.; Lewis, E. Portable 3-d printed plastic optical fibre motion sensor for monitoring of breathing pattern and respiratory rate. In Proceedings of the 2019 IEEE 5th World Forum Internet Things, WF-IoT, Limerick, Ireland, 15–18 April 2019; pp. 144–148.
- Gevaerd, A.; Watanabe, E.Y.; Belli, C.; Marcolino-Junior, L.H.; Bergamini, M.F. A complete lab-made point of care device for non-immunological electrochemical determination of cortisol levels in salivary samples. Sens. Actuators B Chem. 2021, 332, 129532.
- Wang, H.; Yang, H.; Zhang, S.; Zhang, L.; Li, J.; Zeng, X. 3D-Printed Flexible Tactile Sensor Mimicking the Texture and Sensitivity of Human Skin. Adv. Mater. Technol. 2019, 4, 1–8.
- Scordo, G.; Bertana, V.; Ballesio, A.; Carcione, R.; Marasso, S.L.; Cocuzza, M.; Pirri, C.F.; Manachino, M.; Gomez, M.G.; Vitale, A.; et al. Effect of volatile organic compounds adsorption on 3D-printed pegda:Pedot for long-term monitoring devices. Nanomaterials 2021, 11, 94.
- Hassan, K.; Tung, T.T.; Stanley, N.J.; Yap, P.L.; Farivar, F.; Rastin, H.; Nine, M.J.; Losic, D. Graphene inks for extrusion-based 3D micro printing of chemo-resistive sensing devices for volatile organic compounds (VOCs) detection. Nanoscale 2021.