Allosteric Antagonism of the Pregnane X Receptor
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  • Release Date: 2022-10-13
  • PXR
  • pregnane X receptor
  • allosteric site
  • CAR
  • colon cancer
  • nuclear receptor
Video Introduction

This video is adapted from 10.3390/cells11192974

The pregnane X receptor (PXR, NR1I2) is a nuclear receptor superfamily member. Nuclear receptors are mostly activated by exogenous and endogenous compounds. Interestingly, the classified nuclear receptors conserve the DNA binding domain (DBD), but not its ligand-binding domain (LBD). PXR belongs to the NR1I subfamily together with the vitamin D receptor (VDR, NR1I1) and the constitutive androstane receptor (CAR, NR1I3).
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