Acute ankle sprains are common, disabling, and of high clinical relevance, accounting for more than 1 million medical attendances per year worldwide. They are associated with an appreciable socio-economic burden. Approximately 16–40% are sports-related, where time to recovery is important for athletes, professionals, and those training for major competitions. Lateral ankle sprains are the most prevalent (85%), particularly affecting the anterior talofibular ligament.