Begomoviruses are a genus of plant viruses belonging to the family Geminiviridae. They are characterized by their twinned (geminate) capsid structure, which gives them their name ("geminivirus" meaning "twin virus"). Begomoviruses primarily infect dicotyledonous plants, particularly those belonging to the families Solanaceae and Fabaceae, although they can also affect monocotyledonous plants under certain conditions.
Begomoviruses are a genus of plant viruses belonging to the family Geminiviridae. They are characterized by their twinned (geminate) capsid structure, which gives them their name ("geminivirus" meaning "twin virus"). Begomoviruses primarily infect dicotyledonous plants, particularly those belonging to the families Solanaceae and Fabaceae, although they can also affect monocotyledonous plants under certain conditions.
Microscopy of cells infected with Langat virus. The viral protein NS5 (red) interacts with prolidase (green) to prevent cells from mounting an antiviral response. Blue denotes the cell nucleus, a structure where genetic information is stored.
Microscopy of cells infected with Langat virus. The viral protein NS5 (red) interacts with prolidase (green) to prevent cells from mounting an antiviral response. Blue denotes the cell nucleus, a structure where genetic information is stored.
Available randomised controlled trials (RCTs) suggest that dietary polyunsaturated fatty acids (PUFAs) may not protect against heart disease mortality overall. However, those trials used high doses of dietary PUFAs, which do not likely mimic diet in the general public, and the high doses of dietary PUFAs used in many RCTs might have toxic effects. Some meta-analysis reports showed that increasing dietary intake of PUFAs in RCTs failed to show protection against heart disease mortality. Our results showed that, in people from the general public who did not have a prior diagnosis of myocardial infarction (MI), those with PUFA intake in the highest quartile had a 13% lower heart disease mortality risk compared to those in the lowest quartile. Future RCTs could target those without established coronary heart disease and with low dietary PUFA intake, with the intervention to increase PUFA intake to more modest levels (e.g., 10%-11%, equivalent to the mean level in the highest quartile of our study). PUFAs: polyunsaturated fatty acids [1]
Available randomised controlled trials (RCTs) suggest that dietary polyunsaturated fatty acids (PUFAs) may not protect against heart disease mortality overall. However, those trials used high doses of dietary PUFAs, which do not likely mimic diet in the general public, and the high doses of dietary PUFAs used in many RCTs might have toxic effects. Some meta-analysis reports showed that increasing dietary intake of PUFAs in RCTs failed to show protection against heart disease mortality. Our results showed that, in people from the general public who did not have a prior diagnosis of myocardial infarction (MI), those with PUFA intake in the highest quartile had a 13% lower heart disease mortality risk compared to those in the lowest quartile. Future RCTs could target those without established coronary heart disease and with low dietary PUFA intake, with the intervention to increase PUFA intake to more modest levels (e.g., 10%-11%, equivalent to the mean level in the highest quartile of our study). PUFAs: polyunsaturated fatty acids [1]
Wikimedia Commons, ViralZone, SIB Swiss Institute of Bioinformatics
11 Mar 2024
Genomic components of Babuvirus. Multipartite ssDNA genome (+) composed of 6 to 8 circular segments about 1kb in size. Each ssDNA segment have a common stem-loop region and are encapsidated in a separate particle. In addition to genomic DNA, up to 4 satellite-like DNAs are found in some isolates, usually encoding for accessory Rep proteins (para-Rep). These satellite-rep proteins are only able to initiate replication of their genomic DNA, unlike genomic encoded Master-Rep (M-Rep) which promotes replication of all 6 viral genomic ssDNAs (trans-replication).
Genomic components of Babuvirus. Multipartite ssDNA genome (+) composed of 6 to 8 circular segments about 1kb in size. Each ssDNA segment have a common stem-loop region and are encapsidated in a separate particle. In addition to genomic DNA, up to 4 satellite-like DNAs are found in some isolates, usually encoding for accessory Rep proteins (para-Rep). These satellite-rep proteins are only able to initiate replication of their genomic DNA, unlike genomic encoded Master-Rep (M-Rep) which promotes replication of all 6 viral genomic ssDNAs (trans-replication).
Wikimedia Commons, ViralZone, SIB Swiss Institute of Bioinformatics
Electron micrographs of negatively stained grouper nervous necrosis virus like particles (VLPs) used for crystallization. (A) T = 3 GNNV-LPs; (B) T = 1 SVPs of the N-ARM deletion mutant; (C) the delta-P-domain mutant. Bar: 100 nm.[1]
Electron micrographs of negatively stained grouper nervous necrosis virus like particles (VLPs) used for crystallization. (A) T = 3 GNNV-LPs; (B) T = 1 SVPs of the N-ARM deletion mutant; (C) the delta-P-domain mutant. Bar: 100 nm.[1]
Wikimedia Commons, Clément Mazeaud, Wesley Freppel, and Laurent Chatel-Chaix
02 Apr 2024
(A) vRNA is composed of a 5′UTR, one single open reading frame and a 3′UTR. The position of the sequences encoding for the viral proteins within the polyprotein is indicated. The bottom part of the figure shows in details the secondary structures of 5′UTR, capsid-coding region and 3′UTR. The different regions engaged in local pseudoknots and long-range RNA–RNA interactions are indicated and described in detail in the text. (B) Predicted structure of vRNA in its circularized conformation. The coding sequence (except 5′ capsid coding region) is depicted with a dashed line. [1]
(A) vRNA is composed of a 5′UTR, one single open reading frame and a 3′UTR. The position of the sequences encoding for the viral proteins within the polyprotein is indicated. The bottom part of the figure shows in details the secondary structures of 5′UTR, capsid-coding region and 3′UTR. The different regions engaged in local pseudoknots and long-range RNA–RNA interactions are indicated and described in detail in the text. (B) Predicted structure of vRNA in its circularized conformation. The coding sequence (except 5′ capsid coding region) is depicted with a dashed line. [1]
Wikimedia Commons, Clément Mazeaud, Wesley Freppel, and Laurent Chatel-Chaix
Colorized scanning electron micrograph of a single filamentous Ebola virus particle (colorized orange). Image captured at the NIAID Integrated Research Facility in Ft. Detrick, Maryland.
Colorized scanning electron micrograph of a single filamentous Ebola virus particle (colorized orange). Image captured at the NIAID Integrated Research Facility in Ft. Detrick, Maryland.
This is related to the Middle East respiratory syndrome or MERS-coronavirus. “The virus is discovered in a bat population in South Africa and is currently spreading only among animals," NeoCov is postulated to be more contagious and possibly deadlier strain of coronavirus. But is yet to be found in humans. It has not caused any human deaths as reported till now.
This is related to the Middle East respiratory syndrome or MERS-coronavirus. “The virus is discovered in a bat population in South Africa and is currently spreading only among animals," NeoCov is postulated to be more contagious and possibly deadlier strain of coronavirus. But is yet to be found in humans. It has not caused any human deaths as reported till now.
Wikimedia Commons, Li C-X, Shi M, Tian J-H, Lin X-D, Kang Y-J, et al
23 Apr 2024
ML phylogeny for the Orthomyxoviridae-like viruses. The phylogeny is reconstructed using RdRp alignments. Statistical support from the approximate likelihood-ratio test (aLRT) is shown on each node of the tree. The names of the viruses discovered in this study are shown in red. The names of reference sequences, which contain both the GenBank accession number and the virus species name, are shown in black. The names of previously defined genera/families are shown to the right of the phylogeny.
ML phylogeny for the Orthomyxoviridae-like viruses. The phylogeny is reconstructed using RdRp alignments. Statistical support from the approximate likelihood-ratio test (aLRT) is shown on each node of the tree. The names of the viruses discovered in this study are shown in red. The names of reference sequences, which contain both the GenBank accession number and the virus species name, are shown in black. The names of previously defined genera/families are shown to the right of the phylogeny.
Wikimedia Commons, Li C-X, Shi M, Tian J-H, Lin X-D, Kang Y-J, et al
Fig mosaic emaravirus is a plant virus that affects fig trees (Ficus carica) and is responsible for causing mosaic disease in these plants. Belonging to the genus Emaravirus within the family Fimoviridae, it is transmitted by an eriophyid mite vector, Aceria ficus. Infected fig trees typically display symptoms of mosaic patterns on leaves, which appear as irregular patterns of light and dark green patches. These mosaic patterns can vary in severity, and in some cases, infected leaves may also show puckering or distortion.
Fig mosaic emaravirus is a plant virus that affects fig trees (Ficus carica) and is responsible for causing mosaic disease in these plants. Belonging to the genus Emaravirus within the family Fimoviridae, it is transmitted by an eriophyid mite vector, Aceria ficus. Infected fig trees typically display symptoms of mosaic patterns on leaves, which appear as irregular patterns of light and dark green patches. These mosaic patterns can vary in severity, and in some cases, infected leaves may also show puckering or distortion.
This transmission electron micrograph (TEM) revealed the presence of numbers of Nodamura virus virions. At its core, the Nodamura virus possesses a positive-sense, single-stranded RNA virus ((+) ssRNA) genome. Its outer protein coat, or capsid, is icosahedral (T=3) in shape, which means that its composed of 32 equilateral, triangular facets.
This transmission electron micrograph (TEM) revealed the presence of numbers of Nodamura virus virions. At its core, the Nodamura virus possesses a positive-sense, single-stranded RNA virus ((+) ssRNA) genome. Its outer protein coat, or capsid, is icosahedral (T=3) in shape, which means that its composed of 32 equilateral, triangular facets.