Summary

HandWiki is the world's largest wiki-style encyclopedia dedicated to science, technology and computing. It allows you to create and edit articles as long as you have external citations and login account. In addition, this is a content management environment that can be used for collaborative editing of original scholarly content, such as books, manuals, monographs and tutorials.

Expand All
Entries
Topic Review
Type A Influenza Vaccine
Type A influenza vaccine is for the prevention of infection of influenza A virus and also the influenza-related complications. Different monovalent type A influenza vaccines have been developed for different subtypes of influenza A virus including H1N1 and H5N1. Both intramuscular injection or intranasal spray are available on market. Unlike the seasonal influenza vaccines which are used annually, they are usually used during the outbreak of certain strand of subtypes of influenza A. Common adverse effects includes injection site reaction and local tenderness. Incidences of headache and myalgia were also reported with H1N1 whereas cases of fever has also been demonstrated with H5N1 vaccines. It is stated that immunosuppressant therapies would reduce the therapeutic effects of vaccines and that people with egg allergy should go for the egg-free preparations. There are different methods in developing the vaccines. Traditionally, inactivated viral vaccine and live attenuated virus vaccine have been approved. Inactivated viral vaccine is primary used parentally and the live attenuated vaccine is used intranasally. Development of new technologies including the recombinant hemagglutinin technology have widely been studied. Influenza A virus was successfully identified and isolated by Wilson Smith, Christopher Andrewes, and Patrick Laidlaw in the 1930s and the first inactivated monovalent influenza A vaccine was made after a decade. The first H5N1 vaccine was approved in 2007. It was intentionally developed to prepare for the possible H5N1 outbreak in the future. Moreover, in view of the H1N1 outbreak in 2009, H1N1 monovalent vaccines, targeting only H1N1 virus, was produced. Influenza A exists in many subtypes including H5N1, H1N1 and H3N2. Different formulations of monovalent vaccines have been developed over the years to cater different needs and antigens identified.
  • 527
  • 11 Oct 2022
Topic Review
TLR9
Toll-like receptor 9 is a protein that in humans is encoded by the TLR9 gene. TLR9 has also been designated as CD289 (cluster of differentiation 289). It is a member of the toll-like receptor (TLR) family. TLR9 is an important receptor expressed in immune system cells including dendritic cells, macrophages, natural killer cells, and other antigen presenting cells. TLR9 preferentially binds DNA present in bacteria and viruses, and triggers signaling cascades that lead to a pro-inflammatory cytokine response. Cancer, infection, and tissue damage can all modulate TLR9 expression and activation. TLR9 is also an important factor in autoimmune diseases, and there is active research into synthetic TLR9 agonists and antagonists that help regulate autoimmune inflammation.
  • 729
  • 11 Oct 2022
Topic Review
Consultant
A consultant (from Latin: consultare "to deliberate") is a professional who provides expert advice in a particular area such as business, education, law, regulatory compliance, human resources, marketing (and public relations), finance, health care, engineering, science, security (electronic or physical), or any of many other specialized fields. A consultant is usually an expert or an experienced professional in a specific field and has a wide knowledge of the subject matter. The role of consultant outside the medical sphere (where the term is used specifically for a grade of doctor) can fall under one of two general categories: internal consultant and external consultant. By hiring a consultant, clients have access to deeper levels of expertise than would be financially feasible for them to retain in-house on a long-term basis. Moreover, clients can control their expenditures on consulting services by only purchasing as much services from the outside consultant as desired. Consultants provide their advice to their clients in a variety of forms. Reports and presentations are often used. However, in some specialized fields, the consultant may develop customized software or other products for the client. Depending on the nature of the consulting services and the wishes of the client, the advice from the consultant may be made public, by placing the report or presentation online, or the advice may be kept confidential, and only given to the senior executives of the organization paying for the consulting services.
  • 1.2K
  • 11 Oct 2022
Topic Review
Quantum Vacuum Thruster
A quantum vacuum thruster (QVT or Q-thruster) is a theoretical system hypothesized to use the same principles and equations of motion that a conventional plasma thruster would use, namely magnetohydrodynamics (MHD), to make predictions about the behavior of the propellant. However, rather than using a conventional plasma as a propellant, a QVT would interact with quantum vacuum fluctuations of the zero-point field. The concept is controversial and generally not considered physically possible. However, if QVT systems were possible they could eliminate the need to carry propellant, being limited only by the availability of energy.
  • 7.4K
  • 11 Oct 2022
Topic Review
Fiscal Year
A fiscal year (or financial year, or sometimes budget year) is used in government accounting, which varies between countries, and for budget purposes. It is also used for financial reporting by businesses and other organizations. Laws in many jurisdictions require company financial reports to be prepared and published on an annual basis, but generally do not require the reporting period to align with the calendar year (1 January to 31 December). Taxation laws generally require accounting records to be maintained and taxes calculated on an annual basis, which usually corresponds to the fiscal year used for government purposes. The calculation of tax on an annual basis is especially relevant for direct taxation, such as income tax. Many annual government fees—such as Council rates, license fees, etc.—are also levied on a fiscal year basis, while others are charged on an anniversary basis. Some companies—such as Cisco Systems—end their fiscal year on the same day of the week each year, i.e. the day that is closest to a particular date (for example, the Friday closest to 31 December). Under such a system, some fiscal years will have 52 weeks and others 53 weeks. The calendar year is used as the fiscal year by about 65% of publicly traded companies in the United States and for a majority of large corporations in the UK. It's the case in many countries around the world with a few exceptions, for example, Australia, New Zealand, and Japan. Many universities have a fiscal year which ends during the summer to align the fiscal year with the academic year (and, in some cases involving public universities, with the state government's fiscal year), and because the university is normally less busy during the summer months. In the northern hemisphere this is July to the next June. In the southern hemisphere this is calendar year, January to December. Some media/communication-based organizations use a broadcast calendar as the basis for their fiscal year. The fiscal year is usually denoted by the calendar year in which it ends, so United States federal government spending incurred on 14 November 2022 would belong to fiscal year 2023, operating on a fiscal calendar of October–September.
  • 5.9K
  • 11 Oct 2022
Topic Review
Catheter
In medicine, a catheter is a thin tube made from medical grade materials serving a broad range of functions. Catheters are medical devices that can be inserted in the body to treat diseases or perform a surgical procedure. By modifying the material or adjusting the way catheters are manufactured, it is possible to tailor catheters for cardiovascular, urological, gastrointestinal, neurovascular, and ophthalmic applications. Catheters can be inserted into a body cavity, duct, or vessel. Functionally, they allow drainage, administration of fluids or gases, access by surgical instruments, and also perform a wide variety of other tasks depending on the type of catheter. The process of inserting a catheter is "catheterization". In most uses, a catheter is a thin, flexible tube ("soft" catheter) though catheters are available in varying levels of stiffness depending on the application. A catheter left inside the body, either temporarily or permanently, may be referred to as an "indwelling catheter" (for example, a peripherally inserted central catheter). A permanently inserted catheter may be referred to as a "permcath" (originally a trademark).
  • 1.9K
  • 11 Oct 2022
Topic Review
SCOP Formalism
The SCOP formalism or State Context Property formalism is an abstract mathematical formalism for describing states of a system that generalizes both quantum and classical descriptions. The formalism describes entities, which may exist in different states, which in turn have various properties. In addition there is a set of "contexts" (corresponding to measurements) by which an entity may be observed. The formalism has primarily found use outside of physics as a theory of concepts, in particular in the field of quantum cognition, which develops quantum-like models of cognitive phenomena (such as the conjunction fallacy) that may seem paradoxical or irrational when viewed from a perspective of classical states and logic.
  • 913
  • 11 Oct 2022
Topic Review
PRC200
PRC200-SS is an arylalkanolamine TRI being developed by the Mayo Clinic. Sympathomimetic PRC200-SS is the PRC050 eutomer, whereas PRC201 is the distomer. These compounds are preceded by venlafaxine, which Wyeth claims is the first SNRI. Venlafaxine was originally developed as an "opioid" although original screening returned negative results. The authors were not satisfied just to drop venlafaxine from development and continued with their study of the compounds biological activity data. Herein, they discovered that venlafaxine exerts its biological actions via interaction with the monoamine receptors. In particular, the actions of the drug on increasing the amount of 5-HT and NE were documented, although with "potentiated" analogs such as the pm-dichlorophenyl ring substituted derivative, it might be expected to behave as a SNDRI also (but no data was available to support this inference). Venlafaxine itself has been said to behave as a SNDRI at very high doses. This would be more likely to be the case in drug naïve subjects than in users that have already built up significant tolerance. Silicon containing analog of venlafaxine was prepared and demonstrated to be an active SNRI.
  • 574
  • 11 Oct 2022
Topic Review
IBM App Connect Enterprise
IBM App Connect Enterprise (abbreviated as IBM ACE, formerly known as IBM Integration Bus or WebSphere Message Broker) is IBM's integration broker from the WebSphere product family that allows business information to flow between disparate applications across multiple hardware and software platforms. Rules can be applied to the data flowing through the message broker to route and transform the information. The product is an Enterprise Service Bus supplying a communication channel between applications and services in a service-oriented architecture. IBM ACE provides capabilities to build solutions needed to support diverse integration requirements through a set of connectors to a range of data sources, including packaged applications, files, mobile devices, messaging systems, and databases. A benefit of using IBM ACE is that the tool enables existing applications for Web Services without costly legacy application rewrites. ACE avoids the point-to-point strain on development resources by connecting any application or service over multiple protocols, including SOAP, HTTP and JMS. Modern secure authentication mechanisms, including the ability to perform actions on behalf of masquerading or delegate users, through MQ, HTTP and SOAP nodes are supported such as LDAP, X-AUTH, O-AUTH, and two-way SSL. A major focus of IBM ACE in its latest release is the capability of the product's runtime to be fully hosted in a cloud. Hosting the runtime in the cloud provides certain advantages and potential cost savings compared to hosting the runtime on premises as it simplifies the maintenance and application of OS-level patches which can sometimes be disruptive to business continuity. Also, cloud hosting of IBM ACE runtime allows easy expansion of capacity by adding more horsepower to the CPU configuration of a cloud environment or by adding additional nodes in an Active-Active configuration. Another advantage of maintaining ACE runtimes in the cloud is the ability to configure access to your ACE functionality separate and apart from your internal network using DataPower or API Connect devices. This allows people or services on the public internet to access your Enterprise Service Bus without passing through your internal network, which can be a more secure configuration than if your ESB was deployed to your internal on premises network. IBM ACE embeds a Common Language Runtime to invoke any .NET logic as part of an integration. It also includes full support for the Visual Studio development environment, including the integrated debugger and code templates. IBM Integration Bus includes a comprehensive set of patterns and samples that demonstrate bi-directional connectivity with both Microsoft Dynamics CRM and MSMQ. Several improvements have been made to this current release, among them the ability to configure runtime parameters using a property file that is part of the deployed artifacts contained in the BAR ('broker archive') file. Previously, the only way to configure runtime parameters was to run an MQSI command on the command line. This new way of configuration is referred to as a policy document and can be created with the new Policy Editor. Policy documents can be stored in a source code control system and a different policy can exist for different environments (DEV, INT, QA, PROD). IBM ACE is compatible with several virtualization platforms right out-of-the-box, Docker being a prime example. With ACE, you can download from the global Docker repository a runtime of IBM ACE and run it locally. Because ACE has its administrative console built right into the runtime, once the Docker image is active on your local, you can do all the configuration and administration commands needed to fully activate any message flow or deploy any BAR file. In fact, you can construct message flows that are microservices and package these microservices into a Docker deployable object directly. Because message flows and BAR files can contain Policy files, this node configuration can be automatic and no or little human intervention is needed to complete the application deployment.
  • 1.9K
  • 11 Oct 2022
Topic Review
European Union Public Licence
The European Union Public Licence (EUPL) is a free software licence that was written and approved by the European Commission. The licence is available in 23 official languages of the European Union. All linguistic versions have the same validity. Its latest version, EUPL v1.2, was published in May 2017. Revised documentation for v1.2 was issued in late‑2021. Software, mainly produced by European administrations, has been licensed under the EUPL since the launch of the European Open Source Observatory and Repository (OSOR) in October 2008, now part of Joinup collaborative platform.
  • 2.7K
  • 11 Oct 2022
  • Page
  • of
  • 863

Other Entry Collections

>>