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HandWiki is the world's largest wiki-style encyclopedia dedicated to science, technology and computing. It allows you to create and edit articles as long as you have external citations and login account. In addition, this is a content management environment that can be used for collaborative editing of original scholarly content, such as books, manuals, monographs and tutorials.

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Microsoft TypeScript
Microsoft TypeScript is an open-source programming language developed and maintained by Microsoft. It is a strict syntactical superset of JavaScript, and adds optional static typing to the language. TypeScript is designed for development of large applications and transcompiles to JavaScript. As TypeScript is a superset of JavaScript, existing JavaScript programs are also valid TypeScript programs. TypeScript may be used to develop JavaScript applications for both client-side and server-side (Node.js) execution. There are multiple options available for transcompilation. Either the default TypeScript Checker can be used, or the Babel compiler can be invoked to convert TypeScript to JavaScript. TypeScript supports definition files that can contain type information of existing JavaScript libraries, much like C++ header files can describe the structure of existing object files. This enables other programs to use the values defined in the files as if they were statically typed TypeScript entities. There are third-party header files for popular libraries such as jQuery, MongoDB, and D3.js. TypeScript headers for the Node.js basic modules are also available, allowing development of Node.js programs within TypeScript. The TypeScript compiler is itself written in TypeScript and compiled to JavaScript. It is licensed under the Apache 2.0 License. TypeScript is included as a first-class programming language in Microsoft Visual Studio 2013 Update 2 and later, beside C# and other Microsoft languages. An official extension allows Visual Studio 2012 to support TypeScript as well. Anders Hejlsberg, lead architect of C# and creator of Delphi and Turbo Pascal, has worked on the development of TypeScript.
  • 1.3K
  • 19 Oct 2022
Topic Review
Toothlessness
Toothlessness or edentulism is the condition of having no teeth. In organisms that naturally have teeth, it is the result of tooth loss. Organisms that never possessed teeth can also be described as edentulous, such as members of the former zoological classification order of Edentata, which included anteaters and sloths, all of which possess no anterior teeth and either no or poorly developed posterior teeth. In naturally dentate species, edentulism is more than just the simple presence or absence of teeth; it is biochemically complex, because the teeth, jaws, and oral mucosa are not static objects; they are dynamic (changing over time). Processes such as bone remodeling (loss and gain of bone tissue) in the jaws and inflammation of soft tissue in response to the oral microbiota are clinically important for edentulous people. For example, bone resorption in the jaw is frequently how the teeth were able to detach in the first place; the jaw in an edentulous area undergoes further resorption even after the teeth are gone; and insertion of dental implants can elicit new bone formation, leading to osseointegration. Meanwhile, bacteria and yeasts of the oral cavity and the immune system of their host create an immensely complicated and constantly changing interplay that presents clinically as gingivitis, caries, stomatitis, and other periodontal pathology.
  • 1.3K
  • 19 Oct 2022
Topic Review
USS Raeo
USS Raeo (SP-588) was a United States Navy patrol vessel in commission from 1917 to 1919. Prior to her U.S. Navy service, she operated as the motor passenger vessel Raeo from 1908 to 1917. After the conclusion of her U.S. Navy career, she served as the fishery patrol vessel USFS Kittiwake in the United States Bureau of Fisheries fleet from 1919 to 1940 and as US FWS Kittiwake in the Fish and Wildlife Service fleet from 1940 until at least 1945 and perhaps as late as 1948. She was the civilian fishing vessel Raeo from 1948 to 1957, then operated in various roles as Harbor Queen from 1957 to 1997. She became Entiat Princess in 1998 and as of 2009 was still in service.
  • 641
  • 19 Oct 2022
Topic Review
Hypercycle
In chemistry, a hypercycle is an abstract model of organization of self-replicating molecules connected in a cyclic, autocatalytic manner. It was introduced in an ordinary differential equation (ODE) form by the Nobel Prize winner Manfred Eigen in 1971 and subsequently further extended in collaboration with Peter Schuster. It was proposed as a solution to the error threshold problem encountered during modelling of replicative molecules that hypothetically existed on the primordial Earth (see: abiogenesis). As such, it explained how life on Earth could have begun using only relatively short genetic sequences, which in theory were too short to store all essential information. The hypercycle is a special case of the replicator equation. The most important properties of hypercycles are autocatalytic growth competition between cycles, once-for-ever selective behaviour, utilization of small selective advantage, rapid evolvability, increased information capacity, and selection against parasitic branches.
  • 837
  • 19 Oct 2022
Topic Review
SUSE Linux Enterprise Desktop
SUSE Linux Enterprise Desktop (SLED), introduced as Novell Linux Desktop, is a Linux distribution supplied by SUSE and targeted at the business market. It is targeted for desktops. New major versions are released at an interval of 24–36 months, while minor versions (called service packs) are released every 9–12 months. SUSE Linux Enterprise products, including SUSE Linux Enterprise Desktop, receive commercial support and much more intense testing than the openSUSE community product, with the intention that only mature, stable versions of the included components will make it through to the released enterprise product. The current version is SLED 15, which is developed from a common codebase with SUSE Linux Enterprise Server (SLES) and other SUSE Linux Enterprise (SLE) products. SLED includes the GNOME Shell, LibreOffice, Evolution and many other popular open source packages such as Dia, TigerVNC, and lftp. Like SLES, SLED is based on openSUSE Tumbleweed and shares a common codebase with openSUSE Leap. On 15 March 2019, EQT Partners completed its acquisition of SUSE for 2.5 billion USD, leaving SUSE one of the largest independent enterprise Linux vendors.
  • 2.2K
  • 19 Oct 2022
Topic Review
Glycerol Kinase Deficiency
Glycerol kinase deficiency (GKD) is an X-linked recessive enzyme defect that is heterozygous in nature. Three clinically distinct forms of this deficiency have been proposed, namely infantile, juvenile, and adult. National Institutes of Health and its Office of Rare Diseases Research branch classifies GKD as a rare disease, known to affect fewer than 200,000 individuals in the United States. The responsible gene lies in a region containing genes in which deletions can cause Duchenne muscular dystrophy and adrenal hypoplasia congenita. Combinations of these three genetic defects including GKD are addressed medically as Complex GKD.
  • 919
  • 19 Oct 2022
Topic Review
Watson (Computer)
Watson is a question-answering computer system capable of answering questions posed in natural language, developed in IBM's DeepQA project by a research team led by principal investigator David Ferrucci. Watson was named after IBM's founder and first CEO, industrialist Thomas J. Watson. The computer system was initially developed to answer questions on the quiz show Jeopardy! and, in 2011, the Watson computer system competed on Jeopardy! against champions Brad Rutter and Ken Jennings, winning the first place prize of $1 million. In February 2013, IBM announced that Watson software system's first commercial application would be for utilization management decisions in lung cancer treatment at Memorial Sloan Kettering Cancer Center, New York City, in conjunction with WellPoint (now Anthem). In 2013, Manoj Saxena, IBM Watson's business chief said that 90% of nurses in the field who use Watson now follow its guidance.
  • 4.0K
  • 19 Oct 2022
Topic Review
Treatment of Rett Syndrome
Currently there is no cure for Rett syndrome. Treatment is directed towards improving function and addressing symptoms throughout life. A multi-disciplinary team approach is typically used to treat the person throughout life. This team may include primary care physician, physical therapist, occupational therapist, speech-language pathologist, nutritionist, and support services in academic and occupational settings. Treatment of Rett syndrome includes: Because of the increased risk of sudden cardiac death, when long QT syndrome is found on an annual screening EKG it is treated with an anti-arrhythmic such as a beta-blocker. There is some evidence that phenytoin may be more effective than a beta-blocker.
  • 1.2K
  • 19 Oct 2022
Topic Review
Organizational Orientations
Organizational orientation is defined as an individual's predisposition toward work, motivation to work, job satisfaction, and ways of dealing with peers, subordinates, and supervisors on the job (Papa 2008). It can also be referred to the different ways people approach their roles in an organization and the different approaches people have toward work and the place of work in their lives (organizational orientations). Three organizational orientations have been identified as: upward mobile, indifferent, and ambivalent (Goodboy 2007). These three types of orientations are associated with organizational communication behavior and organizational outcomes such as employee job satisfaction and motivation. Presthus believed that these orientations results in employees having different orientations toward work itself, motivation to work, and job satisfaction (McCroskey 1998). These orientations are also believed to be traits, people will have these orientations regardless of the organization they are working for.
  • 1.3K
  • 19 Oct 2022
Topic Review
Custodial Death of P Jayaraj and Bennicks
On 19 June 2020, P. Jayaraj (59 years old) and his son J. Bennicks (also spelled Fennix, Bennix) (31 years old) were picked up for inquiry by the Tamil Nadu Police in Sathankulam, Thoothukudi district for allegedly violating the Indian government's COVID-19 lockdown rules. According to the police, the duo was held for allegedly keeping their mobile accessories shop open beyond permissible hours on June 19. An FIR was filed against the two on 19 June and both were taken into custody. However CBI in chargesheet claimed there were no violation of the lockdown rules. they were sexually assaulted and tortured by the police while in custody, leading to their deaths. On 22 June 2020, Bennicks fell ill and was moved to the Kovilpatti General Hospital, where he died later that day. The following day, 22 June 2020, his father also died. The custodial death of the two men in Tamil Nadu's Sathankulam town in Thoothukudi district sparked massive outrage in the state over police brutality.
  • 19.9K
  • 19 Oct 2022
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