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Medication-associated Osteonecrosis of the Jaw
Medication-related osteonecrosis of the jaw (MON, MRONJ) is progressive death of the jawbone in a person exposed to a medications known to increase the risk of disease, in the absence of a previous radiation treatment. It may lead to surgical complication in the form of impaired wound healing following oral and maxillofacial surgery, periodontal surgery, or endodontic therapy. Particular medications can result in MRONJ, a serious but uncommon side effect in certain individuals. Such medications are frequently used to treat diseases that cause bone resorption such as osteoporosis, or to treat cancer. The main groups of drugs involved are anti-resorptive drugs, and anti-angiogenic drugs. This condition was previously known as bisphosphonate-related osteonecrosis of the jaw because osteonecrosis of the jaws correlating with bisphosphate treatment was frequently encountered, with its first incident occurring in 2003. Denosumab, another antiresorptive drug were also related to this condition. However, newer medications such as anti-angiogenic drugs has been established over the years which were reported to be related to osteonecrosis of the jaw as a side-effect too, hence this condition has been renamed as MRONJ. BON was been nicknamed "bis-phossy jaw" based on its similarity with phossy jaw. There is no known prevention for bisphosphonate-associated osteonecrosis of the jaw. Avoiding the use of bisphosphonates is not a viable preventive strategy on a general-population basis because the medications are beneficial in the treatment and prevention of osteoporosis (including prevention of bony fractures) and treatment of bone cancers. It usually develops after dental treatments involving exposure of bone or trauma, or may arise spontaneously. Patients who develop MRONJ may experience prolonged healing, pain, swelling, infection, exposed bone, after dental procedures, though some patients may have no signs/symptoms.
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  • 19 Oct 2022
Topic Review
Photoemission Electron Microscopy
Photoemission electron microscopy (PEEM, also called photoelectron microscopy, PEM) is a type of electron microscopy that utilizes local variations in electron emission to generate image contrast. The excitation is usually produced by ultraviolet light, synchrotron radiation or X-ray sources. PEEM measures the coefficient indirectly by collecting the emitted secondary electrons generated in the electron cascade that follows the creation of the primary core hole in the absorption process. PEEM is a surface sensitive technique because the emitted electrons originate from a shallow layer. In physics, this technique is referred to as PEEM, which goes together naturally with low-energy electron diffraction (LEED), and low-energy electron microscopy (LEEM). In biology, it is called photoelectron microscopy (PEM), which fits with photoelectron spectroscopy (PES), transmission electron microscopy (TEM), and scanning electron microscopy (SEM).
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  • 19 Oct 2022
Topic Review
Rational Application Developer
Rational Application Developer for WebSphere Software (RAD) is a commercial Eclipse-based integrated development environment (IDE), made by IBM. It provides tools for visually designing, constructing, testing, analyzing, and deploying many types of applications including Java, Java EE, Web 2.0, hybrid mobile, Portal applications, and Web and REST services.
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  • 19 Oct 2022
Topic Review
Cancer Vaccine
A cancer vaccine is a vaccine that either treats existing cancer or prevents development of cancer. Vaccines that treat existing cancer are known as therapeutic cancer vaccines. Some of the vaccines are "autologous", being prepared from samples taken from the patient, and are specific to that patient. Some researchers claim that cancerous cells routinely arise and are destroyed by the immune system (immunosurveillance); and that tumors form when the immune system fails to destroy them. Some types of cancer, such as cervical cancer and liver cancer, are caused by viruses (oncoviruses). Traditional vaccines against those viruses, such as the HPV vaccine and the hepatitis B vaccine, prevent those types of cancer. Other cancers are to some extent caused by bacterial infections (e.g. stomach cancer and Helicobacter pylori). Traditional vaccines against cancer-causing bacteria (oncobacteria) are not further discussed in this article.
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  • 19 Oct 2022
Topic Review
COROT-7b
COROT-7b (previously named COROT-Exo-7b) is an exoplanet orbiting around the star COROT-7, in the constellation Monoceros, at 489 light years from Earth. It was first detected photometrically by the French-led COROT mission and reported in February 2009. Until the announcement of Kepler-10b in January 2011, it was the smallest exoplanet to have its diameter measured, at 1.58 times that of the Earth (which would give it a volume 3.95 times Earth's), and the first potential extrasolar terrestrial planet to be found. The planet has a very short orbital period, revolving around its host star in about 20 hours. Combination of the planet's diameter derived from transit data with the planet's mass derived from radial velocity measurements, meant that the density of CoRoT-7b was about the same as that of Earth and, therefore, that CoRoT-7b was made of rock like Earth and was not a gas giant like Jupiter. The radial velocity observations of CoRoT-7 also detected a second super-Earth, CoRoT-7c, which has a mass 8.4 times that of Earth and orbits every 3.7 days at a distance of 6.9 million km (4.3 million miles).
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  • 19 Oct 2022
Topic Review
Development Communication Policy Science
Development communication policy sciences is the study of policy issues related to development communications. These two branches of social sciences are regarded as distinct and mutually exclusive areas of study but are said to be inextricably linked. According to Nora C. Quebral (2012), the University of the Philippines Los Baños defines Development Communication as the interaction of two social process—development and communication—in any given environment. Quebral, being the "mother of development communication", initially articulated that, in 1971, Development Communication was tentatively defined as "the art and science of human communication applied to the speedy transformation of a country and the mass of its people from poverty to a dynamic state of economic growth that makes possible greater social equality and larger fulfillment of the human potential" (p. 3). Gonzales (no date) defines development as a "quest for an improved quality of life for all" and communication is used to facilitate changes in people and society so that their full potential will be realised. Grounded on the mentioned basic meanings of development and communication, development communication is defined as "the use of communication in development work". Guru (1997) adds that development communication provides a conceptual and practical framework which is meant to accelerate the process of development in all spheres of human life. It is also meant to break the wall of ignorance, thus, breaking the bonds of poverty and oppression. In 1993, Alexander Flor suggested to refine the definition of development communication including the perspective of cybernetics and general systems theory. In 1995, Alexander Flor claimed development communication as the Fifth Theory of the Press. According to the author, it is the suitable system given "the social and political structures" of the Third World and its present universal environment. In UNESCO's approaches to development communication, Jan Servaes cited "while communication on its own will not bring about change and development, neither will change happen without development communication. We need to integrate all our efforts". Flor & Ongkiko (1998) describe development communication in the book titled 'Introduction to Development Communication' as purposive as it primarily uses communication not merely to give information but practically to influence the people- the receivers of information. Nair (1993) adds that development communication brings change, education and inspiration toward development. In 2001, Quebral redefined development communication as the "art and science of human communication linked to a society's planned transformation from a state of poverty to one of dynamic socio-economic growth that makes for greater equity and the larger unfolding of individual potential". The World Bank views development communication as the "integration of strategic communication in development projects" based on a clear understanding of indigenous realities. In 2006, Bassette defined development communication as a "planned and systematic application of communication resources, channels, approaches and strategies to support the goals of socio–economic, political and cultural development". In 2007, the Rome Consensus gave this definition: "Communication for Development is a social process based on dialogue using a broad range of tools and methods. It is also about seeking change at different levels including listening, building trust, sharing knowledge and skills, building policies, debating and learning for sustained and meaningful change. It is not public relations or corporate communication." According to Dr. Florangel Rosario-Braid, a communication expert in the Philippines, development communication is defined as a "purposive approach to communication" that intends to bring about social and economic change in the lives of the greatest number of the population. Braid says Development Communication involves three key elements: (1) Communication involves people's participation, (2) Stakeholders are in active dialogue and consultation, (3) End goal should be to uphold the rights and needs of the people and to achieve "self-reliance and autonomy". Human perspectives of development come into consciousness through communication whereby social reality is negotiated culturally and politically. Communication encompasses all levels of development in society and development initiatives like in health, agriculture, family planning, etc. It is a tool for mitigating global frontiers, contrasts, and divisions and landscaping structural intricacies and dynamic transformations in this sphere—the evidences of change and their social evolution. The Communication Initiative Network defines communication in models of development. To study communication is no less than one way to study policy-making. Communication about development ensures the sustained attention to the issues and which in turn is necessary in getting the essential commitment from world leaders and the wider public to give meaning to the process. The purpose of development communication is to support sustainable change in development operations by engaging key stakeholders, specifically, to: (a) establish conducive environments for assessing risks and opportunities; (b) disseminate information [to generate knowledge, p. 14]; (c) induce behavior and social change. Communicating "development" is framed within economic growth under the Western-centric modernization for underdeveloped countries using traditional vertical (top-down), linear, one-way Sender-Message-Channel-Receiver model based on Lasswell's 1948 communication theory as monologic, persuasive information and message transfer/dissemination/diffusion or selling of ideas through mass media (e.g., advertisements, social marketing). This dominant paradigm which was opposed by the political-economic framework of dependency is in part abandoned and has taken the perspectives of "participation", "empowerment", and socio-cultural "multiplicity" for sustainable or long-term economic growth stipulated by the Millennium Development Goals. Communication is underscored for meaningful participation using horizontal, two-way (dialogic/interactive) communication principles and practices to facilitate stakeholders' engagement throughout the development process. These are captured by the 17 Global Goals to 2030 for sustainable development through social progress. Development communication as a field is defined by: (1) World Bank as "an interdisciplinary field based on empirical research that helps to build consensus while it facilitates the sharing of knowledge to achieve positive change in development initiatives. It is not only about effective dissemination of information but also about using empirical research and two-way communication among stakeholders" and key management tool in assessing socio-political risks and opportunities; and (2) First World Congress of Communication for Development in Rome on October 2006 as "a social process based on dialog using a broad range of tools and methods. It is also about seeking change at different levels, including listening, building trust, sharing knowledge and skills, building policies, debating, and learning for sustained and meaningful change. It is not public relations or corporate communication". Participation refers to people's involvement from social movement and project-based perspectives which could be passive (informed), consultative (provides feedback), functional (takes part in discussion and analysis by horizontal communication), and empowered (equal partners with external professionals in decision-making) along the ladder to change. To move into sustainability, change in people's beliefs and practices take place. However, "...change cannot occur without communication". Development communication accommodates three pillars of sustainable development: (1) ecological; (2) economic; and (3) social issues. In addition, Paolo Mefalopulos of the World Bank, believes that a four-phase methodological framework can help formulate appropriate communication strategies in development communication through (1) research, often referred to as communication-based assessment, or CBA; (2) inputs for the strategy design; (3) production of the materials and implementation of the planned activities; and (4) evaluation. Social, cultural, economic, political, technological and environmental issues and their utterances (also known as "advocacies") in the form of gender concerns, capitalism (e.g., welfare capitalism), marginalization (e.g., social welfare development), poverty, health care, climate change versus sustainable development, and social innovation are brought to public knowledge, and to a consensus for action on the interests, needs and capacities of all concerned through development communication. It also provides stakeholders access to national and local development goals and plans in a communication system where they can communicate horizontally and vertically to coordinate for resource and human development, more so to promote equal opportunities for social welfare, to seek social change involving innovations, and a higher quality of life and values of society. It is a vital part of the political and policy processes. The interface of development communication and policy sciences is the common ground for social and political actions such as reforms in order to: (1) blur discriminatory tensions, (2) reckon the benefit of change, and (3) configure disarrays of allocating equities between the government, corporations, and social sectors. They strengthen the basic framework of management sciences by adding much needed components. Policies articulate directions for their mobilization and regulatory mechanisms since it is set to be anticipatory or forward-looking that is, problems have been envisioned (predicted) at vantage points (strategic) so countermeasures can have minimal consequences. 'Legitimacy' of policies can be defined in terms of their (a) effectiveness and (b) relevance in the real world to address the multidimensional and complex problems. The policy sciences study the process of deciding or choosing and evaluate the relevance of available knowledge for the solution of particular problems. When policy scientists are concerned with government, law, and political mobilization, they focus on particular decisions. Policy scientists also study the choosing process of nongovernmental organizations and individuals and consider the significance of the current stock of knowledge for specific issues. According to Hale (2011), the central aim of policy sciences is to resolve problems [in the service of human dignity] and the diverse human, historical, and contextual element in public policy-making. This is a reiteration of the Lasswellian maxim on public policy in the following key elements: "contextual"; "problem-oriented"; "multi-method inquiry" or diverse empirical methods; "political"; "normative, welfare-oriented" in the case of social policy goals; and posing "interdisciplinarity" or moving between humanities and social sciences. Policy sciences improve decision-making by reinforcing and supporting human dignity to elide the blinders of instrumental reason by addressing the manifold of human experience. According to Laswell (1971), an adequate strategy of problem solving in policy sciences encompasses five intellectual tasks. These five tasks are performed at varying levels of insight and understanding: goal clarification; trend description; analysis of conditions; projection of developments; and invention, evaluation, and selection of alternatives. With this, the policy sciences integrate philosophy, history, science, prophecy, and commitment. Policy is the "plan of action" for administration, management and control of resources. The Evidence-Based Policy in Development Network and Overseas Development Institute provide a mirror of policy sciences on development by information exchange between stakeholders. Policy-making involves analysis of data and options to determine the "best" possible solution to the problem, weighing between welfare, health, expediency, efficiency, justice, and rights, among other things at par with understanding value judgments. The Lessons Database by the Independent Evaluation Department of the Asian Development Bank frames the rigors of balancing a variety of factors in the context of organizational and operational effectiveness. Prioritization towards sustainable development is actually based on estimates of economic and social costs, interests and power structures, scientific information, and ethics. Nair (1987) emphasized that communication can be utilized in providing service to the people. It is essential for mobilizing initiatives and providing information required for action in all fields of development such as agriculture, health and family planning, education and religion. However, MacBride Commission (1980) highlighted that adequate financing must be given to development projects. Without funds, programs of governments will not succeed. Apart from funding, there are other equally important aspects in implementing projects. Communication for Asia (CFA) shares their 5I's methodology in development communication: Inform, Instruct, Inspiration, Insist and Involvement. The 5I's means informing all stakeholders of concerns and priorities to achieve collaboration and cooperation of everyone in mutually sharing expertise and talents in serving the people. The term "policy sciences" was originally coined by Harold D. Lasswell and Daniel Lerner as an approach to understanding and solving problems that draw on and contribute to all fields of knowledge. It is a set of procedures in an integrated and comprehensive form to help clarify and secure common interests. The term "policy sciences" is in plural form to emphasize its interdisciplinary nature. Fraser (1998) elucidated the purposive nature of both development communication and policy sciences, thus intertwining their functions. Policies will greatly aid in the successful implementation of projects as they provide directions on what necessary steps to take. In the work of Alexander Flor, the term "development communication policy sciences" was not used as a whole phrase but was mentioned separately as development communication and policy sciences. He discussed the term according to the linkage of development communication and policy sciences as fundamental and traceable even before either area was afforded the status of science. Communication policy research evolved from the outset as a multi-disciplinary field and domain of various academic disciplines from sociology and political science to law and economics, resulting in the coverage of a myriad of multi-faceted topics. The choice of subjects in communication policy research is affected by sociocultural, political, economic and technological forces that determine the overall framework for communication policy and regulation as well as by the many regulatory objectives in communication. The place of communication in the development process was given a boost when Lerner (1958) wrote his famous treatise 'The Passing of the Traditional Society', in which he acknowledged that mass media growth was one of the three phases of democratic political development (Moemeka, n.d). He pointed out that the mass media had the power to create opportunity for empathy which 'disciplined western men in skills that spell modernity'. Development communication is basically communication for social change to achieve one's potential. This is embodied in Nora Quebral's (1971) definition which states that development communication is the "art and science of human communication applied to the speedy transformation of a country and the mass of its people from poverty to a dynamic state of economic growth that makes possible greater social equity and the larger fulfillment of the human potential." Quebral (2001) redefined development communication to "the art and science of human communication linked to a society's planned transformation from a state of poverty to one of dynamic socio-economic growth that makes for greater equity and the larger unfolding of individual potential." McKee (1992) emphasized that people's involvement is the key to the desired changes. Unless people see themselves as the driving force of their own development, no amount of investment or provision of technology and inputs will bring about any lasting improvements in their living standards. An important and founding impetus for communication policy research came from Harold D. Lasswell, who also figures prominently as a founding father of communication science and policy science (Rogers 1994). He argued that future advances in communication study depended upon the development of a policy focus and upon being a third voice supplying 'a competing appraisal of the images spread by self-serving sources' (Lasswell 1972:307). The conception of the policy sciences on the other hand, is more refined and extended today than at any time in the colorful history of man (Lasswell, 1971). Giving a working definition for it, he noted that policy sciences are concerned with knowledge of and in the decision processes of the public and civic order.
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  • 19 Oct 2022
Topic Review
Resilience (Organizational)
Organizational resilience is defined as "the ability of a system to withstand changes in its environment and still function". It is a capability that involves organizations either being able to endure the environmental changes without having to permanently adapt, or the organization is forced to adapt a new way of working that better suits the new environmental conditions. In recent years, a new consensus of the concept of resilience emerged as a practical response to the decreasing lifespan of organisations and from the key stakeholders, including boards, governments, regulators, shareholders, staff, suppliers and customers to effectively address the issues of security, preparedness, risk, and survivability. An organization that realizes the benefits of the above definitions of resilience will have a high likelihood of maintaining a successful and thriving enterprise. Previously, it was considered that 'organisational resilience' could only be generated from processes and functions such as Risk Management, Business Continuity, IT Disaster Recovery, Crisis Management, Information Security, Operational continuity, Physical Security and so on. These are recognised as key contributors to operational resilience, and “the positive ability of a system or company to adapt itself to the consequences of a catastrophic failure caused by power outage, a fire, a bomb or similar” event or as "the ability of a [system] to cope with change". However, research from many academics including as Hamel & Valikangas in the Harvard Business Review, Boin, Comfort & Demchak and research facility ResOrgs has influenced understanding and lead to new viewpoints on resilience, including that from the BSI Group, being developed by ISO, the Australian government, ResOrgs, ICSA, and professional services firms such as PwC, all of which recognises that processes and functions are but one element of an organisation's resilience web.
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  • 19 Oct 2022
Topic Review
Ancient Pathogen Genomics
Ancient pathogen genomics is a scientific field related to the study of pathogen genomes recovered from ancient human, plant or animal remains. Ancient pathogens are microorganisms, now extinct, that in the past centuries caused several epidemics and deaths worldwide. Their genome, referred to as ancient DNA (aDNA), is isolated from the burial's remains (bones and teeth) of victims of the pandemics caused by these pathogens. The analysis of the genomic features of ancient pathogen genomes allows researchers to understand the evolution of modern microbial strains that can hypothetically generate new pandemics or outbreaks. The analysis of aDNA is carried out by bioinformatic tools and molecular biology techniques to compare ancient pathogens with the modern descendants. The comparison also provides phylogenetic information of these strains.
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  • 19 Oct 2022
Topic Review
Effects of Genocide on Youth
The effects of genocide on youth include psychological and demographic effects that affect the transition into adulthood. These effects are also seen in future generations of youth. Demographic effects involve the transfer of children during genocides. In cases of transfer, children are moved or displaced from their homes into boarding schools, adoptive families, or to new countries with or without their families. There are significant shifts in populations in the countries that experience these genocides. Often, children are then stripped of their cultural identity and assimilated into the culture that they have been placed into. Unresolved trauma of genocide affects future generations of youth. Intergenerational effects help explain the background of these children and analyze how these experiences shape their futures. Effects include the atmosphere of the household they grew up in, pressures to succeed or act in specific ways, and how they view the world in which they live. The passing down of narratives and stories are what form present day perceptions of the past. Narratives are what form future generations' ideas of the people who were either victimized or carried out the genocide. As youth of future generations process the stories they hear they create their own perception of it and begin to identify with a specific group in the story. Youth of future generations begin to form their identity through the narratives they hear as they begin to relate to it and see how the genocide affects them. As stories are passed down, children also begin to understand what their parents or grandparents went through. They use narratives as explanation of why their parents talk about it in the way they do or do not talk about it all. Psychological effects of genocide are also relevant in youth. Youth who experience an extreme trauma at an early age are often incapable of fully understanding the event that took place. As this generation of children transition into adulthood, they sort out the event and recognize the psychological effects of the genocide. It is typical for these young survivors to experience symptoms of posttraumatic stress disorder (PTSD) as well as other psychological disorders. Transitioning out of youth and into adulthood is an important development marker in the lives of all people. Youth who transition into adulthood during a genocide have a different experience than those who do not transition during a genocide. Some youth transition earlier as means of survival. Others are unable to fully transition, remaining in a youth state longer.
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  • 19 Oct 2022
Topic Review
Web Search Engine
A web search engine or Internet search engine is a software system that is designed to carry out web search (Internet search), which means to search the World Wide Web in a systematic way for particular information specified in a textual web search query. The search results are generally presented in a line of results, often referred to as search engine results pages (SERPs). The information may be a mix of links to web pages, images, videos, infographics, articles, research papers, and other types of files. Some search engines also mine data available in databases or open directories. Unlike web directories, which are maintained only by human editors, search engines also maintain real-time information by running an algorithm on a web crawler. Internet content that is not capable of being searched by a web search engine is generally described as the deep web.
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  • 19 Oct 2022
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