Summary

HandWiki is the world's largest wiki-style encyclopedia dedicated to science, technology and computing. It allows you to create and edit articles as long as you have external citations and login account. In addition, this is a content management environment that can be used for collaborative editing of original scholarly content, such as books, manuals, monographs and tutorials.

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Single Molecule Real Time Sequencing
Single molecule real time sequencing (SMRT) is a parallelized single molecule DNA sequencing method. Single molecule real time sequencing utilizes a zero-mode waveguide (ZMW). A single DNA polymerase enzyme is affixed at the bottom of a ZMW with a single molecule of DNA as a template. The ZMW is a structure that creates an illuminated observation volume that is small enough to observe only a single nucleotide of DNA being incorporated by DNA polymerase. Each of the four DNA bases is attached to one of four different fluorescent dyes. When a nucleotide is incorporated by the DNA polymerase, the fluorescent tag is cleaved off and diffuses out of the observation area of the ZMW where its fluorescence is no longer observable. A detector detects the fluorescent signal of the nucleotide incorporation, and the base call is made according to the corresponding fluorescence of the dye.
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  • 01 Nov 2022
Topic Review
2 × 2 Real Matrices
In mathematics, the associative algebra of 2×2 real matrices is denoted by M(2, R). Two matrices p and q in M(2, R) have a sum p + q given by matrix addition. The product matrix p q is formed from the dot product of the rows and columns of its factors through matrix multiplication. For let Then q q* = q* q = (ad − bc) I, where I is the 2×2 identity matrix. The real number ad − bc is called the determinant of q. When ad − bc ≠ 0, q is an invertible matrix, and then The collection of all such invertible matrices constitutes the general linear group GL(2, R). In terms of abstract algebra, M(2, R) with the associated addition and multiplication operations forms a ring, and GL(2, R) is its group of units. M(2, R) is also a four-dimensional vector space, so it is considered an associative algebra. The 2×2 real matrices are in one-one correspondence with the linear mappings of the two-dimensional Cartesian coordinate system into itself by the rule The next section displays M(2,R) is a union of planar cross sections that include a real line. M(2,R) is ring isomorphic to split-quaternions, where there is a similar union but with index sets that are hyperboloids.
  • 1.9K
  • 01 Nov 2022
Topic Review
Here It Goes Again
"Here It Goes Again" is a song by OK Go and is the third released single (the fifth including radio-only singles) from the album Oh No. It was the band's only single to chart on the Billboard Hot 100 until "I Won't Let You Down" entered the Hot 100 in November 2014. Featuring the band dancing on treadmills, the video became a staple on YouTube; at one time being one of their most watched videos, with over 53 million views. In addition, the single peaked at number 36 on the UK Singles Chart on October 1, 2006, hence marking their second UK Top 40 single and their third UK Top 75 single. Its B-side, "The Lovecats", a cover of The Cure's single, was previously released on the band's Do What You Want EP and the single "A Million Ways". An alternate version was nicknamed "UK Surf".
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  • 01 Nov 2022
Topic Review
Social Affordance
Social affordance is a type of affordance. It refers to the properties of an object or environment that permit social actions. Social affordance is most often used in the context of a social technology such as Wiki, Chat and Facebook applications and refers to sociotechnical affordances. Social affordances emerge from the coupling between the behavioral and cognitive capacities of a given organism and the objective properties of its environment. Social affordances – or more accurately sociotechnical affordances – refer as reciprocal interactions between a technology application, its users, and its social context. These social interactions include users’ responses, social accessibility and society related changes. Social affordances are not synonymous with mere factual, statistical frequency; on the contrary, the social normality of primitive forms of coordination can become normative, even in primate societies. A good example clarifies social affordance as follows: “ A wooden bench is supposed to have a sit affordance. A hiker who has walked for hours and passes the wooden bench on a walk along small country roads might perceive the sit affordance of the wooden bench as a function of the degree of fatigue. A very tired hiker will sit on the wooden bench but will not lie down (unless the wooden bench also has a lie affordance). A still fit hiker, however, might not even pick up on the sit affordance of the bench and pass it. The wooden bench is in that case no more than a piece of wood with no further meaning.”
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  • 01 Nov 2022
Topic Review
Fearsome Critters
In North American folklore, fearsome critters were tall tale animals jokingly said to inhabit the wilderness in or around logging camps, especially in the Great Lakes region. Today, the term may also be applied to similar fabulous beasts.
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  • 01 Nov 2022
Topic Review
Social Sequence Analysis
Social sequence analysis is a special application of sequence analysis, a set of methods that were originally designed in bioinformatics to analyze DNA, RNA, and peptide sequences. Social sequence analysis involves the examination of ordered social processes, ranging from microsocial interaction patterns (for example, turn-taking dynamics in conversations) and interpersonal contact dynamics to the development of social hierarchies and macrosocial temporal patterns. The analysis of such patterns can involve descriptive accounts of sequence patterns, statistical event history analysis, optimal matching analysis, narrative or event structure analysis, and dynamic social network sequencing. After being introduced to the social sciences in the 1980s and a period of slow growth during the 1990s, social sequence methods have become increasingly prevalent.
  • 2.4K
  • 01 Nov 2022
Topic Review
Neutral Spine
Good posture refers to the "three natural curves [that] are present in a healthy spine". It is also called neutral spine. Looking directly at the front or back of the body, the 33 vertebrae in the spinal column should appear completely vertical. From a side view, the cervical (neck) region of the spine (C1–C7) is bent inward, the thoracic (upper back) region (T1–T12) bends outward, and the lumbar (lower back) region (L1–L5) bends inward. The sacrum (tailbone area) (S1–S5 fused) and coccyx (on average 4 fused) rest between the pelvic bones. A neutral pelvis is in fact slightly anteriorly rotated which means the anterior superior iliac spines should be just in front of the pubic symphysis not in the same vertical line.
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  • 01 Nov 2022
Topic Review
Fresnel Imager
A Fresnel imager is a proposed ultra-lightweight design for a space telescope that uses a Fresnel array as primary optics instead of a typical lens. It focuses light with a thin opaque foil sheet punched with specially shaped holes, thus focusing light on a certain point by using the phenomenon of diffraction. Such patterned sheets, called Fresnel zone plates, have long been used for focusing laser beams, but have so far not been used for astronomy. No optical material is involved in the focusing process as in traditional telescopes. Rather, the light collected by the Fresnel array is concentrated on smaller classical optics (e.g. 1/20th of the array size), to form a final image. The long focal lengths of the Fresnel imager (a few kilometers) require operation by two-vessel formation flying in space at the L2 Sun-Earth Lagrangian point. In this two spacecraft formation-flying instrument, one spacecraft holds the focussing element: the Fresnel interferometric array; the other spacecraft holds the field optics, focal instrumentation, and detectors.
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  • 01 Nov 2022
Topic Review
Epoetin Alfa
Epoetin alfa is a human erythropoietin produced in cell culture using recombinant DNA technology. Authorised by the European Medicines Agency on 28 August 2007, it stimulates erythropoiesis (increasing red blood cell levels) and is used to treat anemia, commonly associated with chronic kidney failure and cancer chemotherapy. Epoetin is manufactured and marketed by Amgen under the brand name Epogen. Johnson & Johnson subsidiary Janssen Biotech (formerly Ortho Biotech Products, LP), sells the same drug under the name Procrit, pursuant to a product license agreement. The average cost per patient in the U.S. was $8,447 in 2009. Darbepoetin alfa (rINN) /dɑːrbəˈpɔɪtɪn/ is a glycosylation analog of erythropoietin containing two additional N-linked carbohydrate chains, also manufactured and marketed by Amgen, with a brand name of Aranesp. The Food and Drug Administration (FDA) warnings and safety precautions for Procrit, Epogen and Aranesp are identical. For several years, epoetin alfa has accounted for the single greatest drug expenditure paid by the U.S. Medicare system; in 2010, the program paid $2 billion for the drug. Raising hemoglobin levels has been found in some studies to be associated with higher risks of thrombotic events, strokes and death. It is on the World Health Organization's List of Essential Medicines.
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  • 01 Nov 2022
Topic Review
Nepal Risk Reduction Consortium
The Nepal Risk Reduction Consortium (NRRC) was launched by the Government of Nepal (GoN) and a group of international organizations working to promote the UN International Strategy for Disaster Reduction (ISDR) in 2009. It exists to bridge the spectrum of development and humanitarian partners in order to support the Government of Nepal in taking action to implement long-term Disaster risk reduction (DRR). The founding members of the NRRC were the Asian Development Bank (ADB), the International Federation of the Red Cross and Red Crescent Societies (IFRC), the United Nations Development Programme (UNDP), the UN Office for the Coordination of Humanitarian Affairs (OCHA), the UN International Strategy for Disaster Reduction (ISDR) and the World Bank. Since 2009, new NRRC members have included AusAid, the Department for International Development (DFID), the Humanitarian Aid Department of the European Commission (ECHO), the embassy of Japan, the US Embassy and the World Health Organization (WHO). The NRRC has developed a Disaster Risk Reduction Action Plan that builds on the GoN National Strategy for Disaster Risk Management (NSDRM). Based on consultations with key stakeholders to identify disaster risk reduction priorities that are urgent and viable, five flagship areas were identified and proposed. Consortium members act as coordinators of these flagship areas together with the relevant Government Ministry. Location: P.O. Box 107 Kathmandu, Nepal
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