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HandWiki. Epoetin Alfa. Encyclopedia. Available online: https://encyclopedia.pub/entry/32208 (accessed on 26 September 2026).
HandWiki. Epoetin Alfa. Encyclopedia. Available at: https://encyclopedia.pub/entry/32208. Accessed September 26, 2026.
HandWiki. "Epoetin Alfa" Encyclopedia, https://encyclopedia.pub/entry/32208 (accessed September 26, 2026).
HandWiki. (2022, November 01). Epoetin Alfa. In Encyclopedia. https://encyclopedia.pub/entry/32208
HandWiki. "Epoetin Alfa." Encyclopedia. Web. 01 November, 2022.
Epoetin Alfa
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The content is sourced from: https://handwiki.org/wiki/Chemistry:Epoetin_alfa

Epoetin alfa is a human erythropoietin produced in cell culture using recombinant DNA technology. Authorised by the European Medicines Agency on 28 August 2007, it stimulates erythropoiesis (increasing red blood cell levels) and is used to treat anemia, commonly associated with chronic kidney failure and cancer chemotherapy. Epoetin is manufactured and marketed by Amgen under the brand name Epogen. Johnson & Johnson subsidiary Janssen Biotech (formerly Ortho Biotech Products, LP), sells the same drug under the name Procrit, pursuant to a product license agreement. The average cost per patient in the U.S. was $8,447 in 2009. Darbepoetin alfa (rINN) /dɑːrbəˈpɔɪtɪn/ is a glycosylation analog of erythropoietin containing two additional N-linked carbohydrate chains, also manufactured and marketed by Amgen, with a brand name of Aranesp. The Food and Drug Administration (FDA) warnings and safety precautions for Procrit, Epogen and Aranesp are identical. For several years, epoetin alfa has accounted for the single greatest drug expenditure paid by the U.S. Medicare system; in 2010, the program paid $2 billion for the drug. Raising hemoglobin levels has been found in some studies to be associated with higher risks of thrombotic events, strokes and death. It is on the World Health Organization's List of Essential Medicines.

glycosylation red blood cell hemoglobin levels

References

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  2. "Efficacy and safety of epoetin alfa in critically ill patients". The New England Journal of Medicine 357 (10): 965–76. September 2007. doi:10.1056/NEJMoa071533. PMID 17804841.  https://dx.doi.org/10.1056%2FNEJMoa071533
  3. "Erythropoietin: a candidate compound for neuroprotection in schizophrenia". Molecular Psychiatry 9 (1): 42–54. January 2004. doi:10.1038/sj.mp.4001442. PMID 14581931.  https://dx.doi.org/10.1038%2Fsj.mp.4001442
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  7. "Passage of erythropoietic agents across the blood-brain barrier: a comparison of human and murine erythropoietin and the analog darbepoetin alfa". European Journal of Pharmacology 505 (1–3): 93–101. November 2004. doi:10.1016/j.ejphar.2004.10.035. PMID 15556141.  https://dx.doi.org/10.1016%2Fj.ejphar.2004.10.035
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  9. "Early erythropoiesis-stimulating agents in preterm or low birth weight infants". The Cochrane Database of Systematic Reviews 11: CD004863. November 2017. doi:10.1002/14651858.CD004863.pub5. PMID 29145693.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=6486170
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  13. "FDA Public Health Advisory: Erythropoiesis-Stimulating Agents (ESAs): Epoetin alfa (marketed as Procrit, Epogen), Darbepoetin alfa (marketed as Aranesp)". https://www.fda.gov/cder/drug/advisory/RHE2007.htm. 
  14. "Information for Healthcare Professionals: Erythropoiesis Stimulating Agents (ESA)". https://www.fda.gov/cder/drug/InfoSheets/HCP/RHE2007HCP.htm. 
  15. "Erythropoiesis Stimulating Agents: Aranesp (darbepoetin alfa), Epogen (epoetin alfa), and Procrit (epoetin alfa)". MedWatch - 2007 Safety Information Alerts. U.S. Food and Drug Administration. 3 January 2008. https://www.fda.gov/medwatch/safety/2007/safety07.htm#ESA2. 
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  19. "Epoetin alfa Interactions Checker". https://www.drugs.com/drug-interactions/epoetin-alfa.html. 
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  23. "Binocrit EPAR". 17 September 2018. https://www.ema.europa.eu/en/medicines/human/EPAR/binocrit. 
  24. "Epoetin Alfa Hexal EPAR". 17 September 2018. https://www.ema.europa.eu/en/medicines/human/EPAR/epoetin-alfa-hexal. 
  25. "Abseamed EPAR". https://www.ema.europa.eu/en/medicines/human/EPAR/abseamed. 
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