Summary

HandWiki is the world's largest wiki-style encyclopedia dedicated to science, technology and computing. It allows you to create and edit articles as long as you have external citations and login account. In addition, this is a content management environment that can be used for collaborative editing of original scholarly content, such as books, manuals, monographs and tutorials.

Expand All
Entries
Topic Review
Certis CISCO
Coordinates: 1°19′16.88″N 103°53′30.67″E / 1.3213556°N 103.8918528°E / 1.3213556; 103.8918528 Certis CISCO Security Private Limited, formerly CISCO Security Private Limited, is one of the five commercial Auxiliary Police forces authorized to provide armed security officers to government organizations as well as private companies or individuals in Singapore. It has its roots as a department of the Singapore Police Force (SPF), which branched out as the Commercial and Industrial Security Corporation, a statutory board with a monopoly over most areas of the local private armed security industry. From 1 June 2005, the statutory board was dissolved and Cisco Security Pte Ltd was formed upon its corporatisation as a fully owned subsidiary of Temasek Holdings, and inaugurated on 5 July 2005. The abbreviation of the former statutory board, "CISCO", was retained due to its reputation in the local market. The company was renamed as Certis CISCO Security Pte Ltd on 13 September 2007. Cisco Annual Security Report on 20 January 2016 reveals a decline in defender confidence and the increased impact of industrialized attackers. As the oldest Auxiliary Police Force with a monopoly over most of the private armed security sector in Singapore for 33 years, CISCO maintains a visible presence in many key establishments, including the private residences of VVIPs. They were deployed in major events such as the Singapore 2006 IMF Meetings, the New Year Countdown at Marina Bay in 2007 and 2008, the Chingay Parade and the Thaipusam processions. They also continue to dominate some services such as the transportation of valuables, most visibly in the form of delivering cash to automated teller machines.
  • 4.2K
  • 08 Nov 2022
Topic Review
Basic Symptoms of Schizophrenia
Basic symptoms of schizophrenia are subjective symptoms, described as experienced from a person's perspective, which show evidence of underlying psychopathology. Basic symptoms have generally been applied to the assessment of people who may be at risk to develop psychosis. Though basic symptoms are often disturbing for the person, problems generally do not become evident to others until the person is no longer able to cope with their basic symptoms. Basic symptoms are more specific to identifying people who exhibit signs of prodromal psychosis (prodrome) and are more likely to develop schizophrenia over other disorders related to psychosis. Schizophrenia is a psychotic disorder, but is not synonymous with psychosis. In the prodrome to psychosis, uncharacteristic basic symptoms develop first, followed by more characteristic basic symptoms and brief and self-limited psychotic-like symptoms, and finally the onset of psychosis. People who were assessed to be high risk according to the basic symptoms criteria have a 48.5% likelihood of progressing to psychosis. In 2015, the European Psychiatric Association issued guidance recommending the use of a subscale of basic symptoms, called the Cognitive Disturbances scale (COGDIS), in the assessment of psychosis risk in help-seeking psychiatric patients; in a meta-analysis, COGDIS was shown to be as predictive of transition to psychosis as the Ultra High Risk (UHR) criteria up to 2 years after assessment, and significantly more predictive thereafter. The basic symptoms measured by COGDIS, as well as those measured by another subscale, the Cognitive-Perceptive basic symptoms scale (COPER), are predictive of transition to schizophrenia.
  • 821
  • 08 Nov 2022
Topic Review
Crosstalk
Biological crosstalk refers to instances in which one or more components of one signal transduction pathway affects another. This can be achieved through a number of ways with the most common form being crosstalk between proteins of signaling cascades. In these signal transduction pathways, there are often shared components that can interact with either pathway. A more complex instance of crosstalk can be observed with transmembrane crosstalk between the extracellular matrix (ECM) and the cytoskeleton.
  • 3.4K
  • 08 Nov 2022
Topic Review
Ram Pickup
The Ram pickup (formerly the Dodge Ram pickup) is a full-size pickup truck manufactured by FCA US LLC (formerly Chrysler Group LLC) and marketed as of 2011 onwards under the Ram Trucks brand. The current fifth-generation Ram debuted at the 2018 North American International Auto Show in Detroit, Michigan in January of that year. Previously, Ram was part of the Dodge line of light trucks. The name Ram was first used in 1932–1954 Dodge Trucks, then returned on the redesigned 1981 Ram and Power Ram, following the retiring and rebadging of the Dodge D Series pickup trucks as well as B-series vans. Ram trucks have been named Motor Trend magazine's Truck of the Year six times; the second-generation Ram won the award in 1994, the third-generation Ram Heavy Duty won the award in 2003, the fourth-generation Ram Heavy Duty won in 2010 and the fourth-generation Ram 1500 won in 2013 and 2014, and the current fifth-generation Ram 1500 won in 2019.
  • 3.6K
  • 08 Nov 2022
Topic Review
Z4 (Computer)
The Z4 was arguably the world's first commercial digital computer. It was designed, and manufactured by early computer scientist Konrad Zuse's company Zuse Apparatebau, for an order placed by Henschel & Son, in 1942; though only partially assembled in Berlin, then completed in Göttingen, and not delivered by the defeat of Nazi Germany, in 1945. The Z4 was Zuse's final target for the Z3 design. Like the earlier Z2, it comprised a combination of mechanical memory and electromechanical logic, so was not a true electronic computer.
  • 2.7K
  • 08 Nov 2022
Topic Review
Agricultural Biotechnology
Agricultural biotechnology, also known as agritech, is an area of agricultural science involving the use of scientific tools and techniques, including genetic engineering, molecular markers, molecular diagnostics, vaccines, and tissue culture, to modify living organisms: plants, animals, and microorganisms. Crop biotechnology is one aspect of agricultural biotechnology which has been greatly developed upon in recent times. Desired trait are exported from a particular species of Crop to an entirely different species. These transgene crops possess desirable characteristics in terms of flavor, color of flowers, growth rate, size of harvested products and resistance to diseases and pests.
  • 2.3K
  • 08 Nov 2022
Topic Review
Schweizer 300
The Schweizer RSG 300 series (formerly Sikorsky S300, Hughes 300 and Schweizer 300) family of light utility helicopters was originally produced by Hughes Helicopters, as a development of the Hughes 269. Later manufactured by Schweizer Aircraft, the basic design has been in production for almost 50 years. The single, three-bladed main rotor and piston-powered S-300 is mostly used as a cost-effective platform for training and agriculture.
  • 2.9K
  • 08 Nov 2022
Topic Review
List of Common Fish Names
This is a list of common fish names. While some common names refer to a single species or family, others have been used for a confusing variety of types; the articles listed here should explain the possibilities if the name is ambiguous.
  • 102.8K
  • 08 Nov 2022
Topic Review
Commune (Model of Government)
The commune, as a model of government, is generally advocated by some communists, revolutionary socialists, and anarchists. Communes are an organizational community with social cohesion derived from a shared culture. As a governing community, a commune often entails some degree of local governance, communal ownership, and cultural cohesion. However, models that do not include all three aspects may still be described as communes. At its core, a commune is just an organization which creates social conditions that prioritize the primacy of the collective over the individual. Many different forms of commune-based governments are possible, such as a local and sovereign community which is both a microstate and a nation-state, a federated commune which lacks a degree of sovereignty under the rule of a larger state, or a larger national community which focuses more on aspects of communal ownership rather than communal governance.
  • 7.5K
  • 09 Nov 2022
Topic Review
Cannabinoid Receptor Antagonist
A cannabinoid receptor antagonist, also known simply as a cannabinoid antagonist or as an anticannabinoid, is a type of cannabinoidergic drug that binds to cannabinoid receptors (CBR) and prevents their activation by endocannabinoids. They include antagonists, inverse agonists, and antibodies of CBRs. The discovery of the endocannabinoid system led to the development of CB1 receptor antagonists. The first CBR inverse agonist, rimonabant, was described in 1994. Rimonabant blocks the CB1 receptor selectively and has been shown to decrease food intake and regulate body-weight gain. The prevalence of obesity worldwide is increasing dramatically and has a great impact on public health. The lack of efficient and well-tolerated drugs to cure obesity has led to an increased interest in research and development of CBR antagonists. Cannabidiol (CBD), a naturally occurring cannabinoid, is a non-competitive CB1/CB2 receptor antagonist. And Δ9-tetrahydrocannabivarin (THCV), a naturally occurring cannabinoid, modulate the effects of THC via direct blockade of cannabinoid CB1 receptors, thus behaving like first-generation CB1 receptor inverse agonists, such as rimonabant. CBD is a very low-affinity CB1 ligand, that can nevertheless affect CB1 receptor activity in vivo in an indirect manner, while THCV is a high-affinity CB1 receptor ligand and potent antagonist in vitro and yet only occasionally produces effects in vivo resulting from CB1 receptor antagonism. THCV has also high affinity for CB2 receptors and signals as a partial agonist, differing from both CBD and rimonabant.
  • 2.2K
  • 08 Nov 2022
  • Page
  • of
  • 863

Other Entry Collections

>>