Summary

On 11 March 2020, the World Health Organization declared COVID-19 a global pandemic, and the disease now affects nearly every country and region. Caused by SARS-CoV-2, COVID-19 continues nearly 18 months later to present significant challenges to health systems and public health in both hemispheres, as well as the economies of every country. The morbidity and mortality of the infection caused by SARS-CoV-2 has been significant, and various waves of disease outbreaks initially overwhelmed many hospitals and clinics and continue to do so in many countries. This influences everyone, and public health countermeasures have been dramatic in terms of their impact on employment, social systems, and mental health. This entry collection aims to gather diverse fields about COVID-19, including in epidemiology, public health, medicine, genetics, systems biology, informatics, data science, engineering, sociology, anthropology, nursing, environmental studies, statistics, and psychology.

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Entries
Topic Review
Immunological Mechanisms of Vaccine-Induced Protection against SARS-CoV-2 Infections
SARS-CoV-2 is attached to host cells via binding to the viral spike (S) proteins and its cellular receptors angiotensin-converting enzyme 2 (ACE2). Consequently, the S protein is primed with serine proteases TMPRSS2 and TMPRSS4, which facilitate the fusion of viral and cellular membranes result in the entry of viral RNA into the host cell. The long-term protective immunity is provided by the vaccine antigen (or pathogen)-specific immune effectors and the activation of immune memory cells that can be efficiently and rapidly reactivated upon pathogen exposure.
  • 642
  • 29 Nov 2021
Topic Review
Kidney Transplantation during the SARS-CoV-2 Pandemic in Israel
Kidney transplant recipients may be at a high risk of developing critical COVID-19 illness due to chronic immunosuppression and comorbidities. Kidney donors were scrutinized for prevention of disease transmission to the donor and exposure of the operating room and surgical ward staff.
  • 565
  • 25 Nov 2021
Topic Review
UN and COVID-19: Economic Stimulation in Fragile States
United Nations support for fragile economies to overcome COVID-19's economic impact .
  • 477
  • 25 Nov 2021
Topic Review
Mechanisms of Immunothrombosis by SARS-CoV-2
During COVID-19 infection, SARS-Cov-2 interacts with Angiotensin-Converting Enzyme 2 (ACE2), NRP1, endothelial cells, platelets, neutrophil extracellular traps (NETs), thrombin, extracellular DNA (eDNA), and histones, inducing heterogeneous clinical manifestations characterized by endothelial damage, microthrombosis, and inflammation.
  • 502
  • 22 Nov 2021
Topic Review
COVID-19 Pandemic on Tourism in Developing City
Tourism generates huge revenue for destinations and contributes to overall economic development for a plethora of countries, especially tourism-dependent nations. In other words, there is a strong link between tourism development and economic growth, which also stimulates the development of other related businesses in a country (Haryanto 2020). However, tourism is a vulnerable industry which may crash due to potential risks such as global pandemics (Shakya 2009). The COVID-19 pandemic has inflicted serious and widespread impacts on a wide range of economic sectors, particularly the tourism industry. This is likely true for countries where the economy mainly depends on tourism, where businesses face much bigger challenges for economy resilience in both the short and long term. An abundance of consequences, including regional to national lockdowns, as well as the suspension or cancellation of tourism- and hospitality-related services, have increasingly occurred on the global scale.
  • 573
  • 22 Nov 2021
Topic Review
SARS-CoV-2 Transmission in Livestock Industry and Agro-environment
The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a public health emergency that turns the year 2020–2021 into annus horribilis for millions of people across international boundaries. The interspecies transmission of this zoonotic virus and mutated variants are aided by exposure dynamics of infected aerosols, fomites and intermediate reservoirs. The spike in the first, second and third waves of coronavirus confirms that herd immunity is not yet reached and everyone including livestock is still vulnerable to the infection. Of serious concern are the communitarian nature of agrarians in the livestock sector, aerogenous spread of the virus and attendant cytocidal effect in permissive cells following activation of pathogen recognition receptors, replication cycles, virulent mutations, seasonal spike in infection rates, flurry of reinfections and excess mortalities that can affect animal welfare and food security. As the capacity to either resist or be susceptible to infection is influenced by numerous factors, identifying coronavirus-associated variants and correlating exposure dynamics with viral aerosols, spirometry indices, comorbidities, susceptible blood types, cellular miRNA binding sites and multisystem inflammatory syndrome remains a challenge where the lethal zoonotic infections are prevalent in the livestock industry, being the hub of dairy, fur, meat and egg production. This entry provides insights into the complexity of the disease burden and recommends precision smart-farming models for upscaling biosecurity measures and adoption of digitalised technologies (robotic drones) powered by multiparametric sensors and radio modem systems for real-time tracking of infectious strains in the agro-environment and managing the transition into the new-normal realities in the livestock industry.
  • 570
  • 22 Nov 2021
Topic Review
Monoclonal Antibodies in COVID-19
Monoclonal antibodies (MAbs) are one of the emerging therapeutic agents efficacious for treating infectious diseases such as COVID-19. They are one of the fastest-growing pharmaceuticals and are considered to be highly specific in their action. MAbs are lab-grown antibodies that specifically target the pathogen, causing its destruction immediately.
  • 543
  • 19 Nov 2021
Topic Review
Treat COVID-19 through Mass Spectrometry and Next-Generation Sequencing
COVID-19 is caused by a coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The difficulty in containing SARS-CoV-2 has underscored the need for techniques such as mass spectrometry in the diagnosis and treatment of COVID-19. Mass spectrometry-based methods have been employed in several studies to detect changes in interactions among host proteins, and between host and viral proteins in COVID-19 patients. The methods have also been used to characterize host and viral proteins, and analyze lipid metabolism in COVID-19 patients. Information obtained using the above methods are complemented by high-throughput analysis of transcriptomic and epigenomic changes associated with COVID-19, coupled with next-generation sequencing.
  • 515
  • 22 Nov 2021
Topic Review
Travel sentiment after COVID-19
Tourism and hospitality actors face an unprecedented challenge in reigniting these industries through digital communication. All past knowledge regarding tourist behavior and preferences has been rendered less relevant since the outbreak of the COVID-19 pandemic. These changes result in enforced changes that need to be acknowledged. Several reports have pointed to the existence of a travel sentiment. This travel sentiment integrates the travel intentions and concerns, and trip planning which can be actionable by digital communication.
  • 1.3K
  • 18 Nov 2021
Topic Review
Vitamin C Intervention for Critical COVID-19
Coronaviruses are single-stranded ribonucleic acid viruses comprising a lipid bilayer containing crown-like spikes (Latin, Corona = Crown) on their outer surface.
  • 459
  • 18 Nov 2021
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