Summary

On 11 March 2020, the World Health Organization declared COVID-19 a global pandemic, and the disease now affects nearly every country and region. Caused by SARS-CoV-2, COVID-19 continues nearly 18 months later to present significant challenges to health systems and public health in both hemispheres, as well as the economies of every country. The morbidity and mortality of the infection caused by SARS-CoV-2 has been significant, and various waves of disease outbreaks initially overwhelmed many hospitals and clinics and continue to do so in many countries. This influences everyone, and public health countermeasures have been dramatic in terms of their impact on employment, social systems, and mental health. This entry collection aims to gather diverse fields about COVID-19, including in epidemiology, public health, medicine, genetics, systems biology, informatics, data science, engineering, sociology, anthropology, nursing, environmental studies, statistics, and psychology.

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The Increase in Addiction during COVID-19
The increase in addiction during COVID-19 is a condition that emerged as an aftermath of COVID-19-related events, for instance, fear of the spread of COVID-19, self-abstention from many activities, and restrictions established by the lockdown measures. This condition includes substance addictions such as drugs and alcohol but also behavioral addictions such as gambling, gaming, pornography, and smartphone and internet misuse.
  • 3.7K
  • 13 Apr 2022
Topic Review
Novel Heterocyclic Derivatives against SARS-CoV-2
The heterocyclic ring derivatives were evaluated for their therapeutic potentials against SARS-CoV-2 Mpro, Spro, and RdRp. All the compounds reported showed excellent binding affinities with the various target proteins. Among the derivatives, compound C13 exhibits the highest binding affinity for the drug targets Spro (−10.6 kcal/mol) and RdRp (−9.5 kcal/mol), respectively. At a binding affinity of −8.8kcal/mol, the compound C15 exhibits the highest binding affinity for Mpro. The compounds interacted with the LEU A:271, LEU A:287, ASP A:289, and LEU A:272 of Mpro and the HIS A:540, PRO A:415, PHE A:486, and LEU A:370 of the Spro receptor binding motif and some active site amino acids of RdRp. The compounds also possess a favourable ADMET profile and showed no tendency towards hERG inhibition, hepatotoxicity, carcinogenicity, mutagenicity, or drug-liver injury. 
  • 823
  • 17 Dec 2021
Topic Review
COVID-19 Limitations on Doodling in Measuring Burnout
Burnout is a negative, job-related psychological state exhibited through physical fatigue, emotional exhaustion, and loss of motivation. Pre-COVID-19, doodling was identified as a measure of burnout in researchers attending a weekly, in-person health narratives research group manifesting team mindfulness. Doodling was not retained as a possible measure of burnout during COVID-19 once the weekly health narratives research group moved online and aware attention to present perceptions—one aspect of team mindfulness—was no longer evident.
  • 1.1K
  • 17 Dec 2021
Topic Review
COVID-19, Respiratory Diseases & Drug-Drug Interactions
The absence of COVID-19-targeted treatments has led scientist to exploit available scientific evidence for potential efficient drugs that may block biological pathways of SARS-CoV-2 and several molecules have been emerged as promising pharmacological agents. Then again, due to the criticality of the disease, it is important for healthcare providers in COVID-19 clinics to recognize potential drug-drug interactions (DDIs) that may lead to adverse drug reactions (ADRs) and additional burdens in patients' health status from the administration of these agents.
  • 959
  • 17 Dec 2021
Topic Review
Biomass Supply Chains in Post-COVID-19 Recovery
Researchers investigates how biomass supply chains (BSChs) for bioenergy within the broader bioeconomy could contribute to the post-COVID-19 recovery in three dimensions: boosting economic growth, creating jobs, and building more resilient and cleaner energy systems in four future scenarios, in the short term (by 2023) and long term (by 2030).
  • 1.2K
  • 17 Dec 2021
Topic Review
Sustainable Finance and COVID-19
Both the GARCH models and the event study suggest that funds with a higher ESG rating were able to outperform other funds during the COVID-19 period. These funds had a greater level of resilience and exhibited a lower level of risk contagion during the pandemic. These instruments appear to assume the role of risk protection and should be considered a means of both promoting sustainable growth and minimizing portfolio risk.
  • 974
  • 16 Dec 2021
Topic Review
Impact of the COVID-19 to the Energy Sector
In order to control the COVID-19 pandemic, the governments of the world started to implement measures regarding social distance and social contacts, including closures of cities, work and study relocations, and work suspension. The epidemical situation and the lockdown of the economy by governments in various countries caused changes in production, changes in the habits of energy consumers and other energy-related changes.
  • 1.1K
  • 16 Dec 2021
Topic Review
Strategies Adopted during the Coronavirus Pandemic
The COVID-19 generate several psychological repercussions, such as: depression, anxiety, suicide, self-mutilation and increased consumption of alcohol and other drugs,as well as in socioeconomic and political aspects that were aggravated by structural inequalities and inequities in the countries, increasing poverty, misery, unemployment and hunger. These factors become more serious and complex for people who struggle with substance use disorders (SUD) not only because they increase the risk of COVID-19, but also because of the accentuation of the condition of vulnerability. Although actions as social distancing was the only way to mitigate the COVID-19 pandemic, these strategies limited access and continuity of monitoring in the intra- and inter-sectoral network. Because of that during the pandemic period, several services reduced or stopped functioning, varying according to the program areas. As stated by PAHO (2021) Mental health services in the Americas had a 77% reduction of health care compared to other services and programs. Due this context, the present study developed a scoping review to map strategies and actions adopted in SUD treatment facilities. The strategies were: 1) Telehealth/telemedicine support (64%); 2) Adequacy of prescription and distribution of medications (46%); 3) Reorganization of face-to-face healthcare services (39%); 4) Approaches related to the prevention of COVID-19 among patients (29%) and 5) Other strategies in the routine of health care (21%). 
  • 803
  • 17 Dec 2021
Topic Review
Sleep Dysfunction in COVID-19 Patients
Sleep is an important factor for human well being in order to maintain daily functions, while lack of sleep may lead to an increase in accidents, mood changes, impaired psychological functioning and concentration, and decreased immune response.Sleep problems appear to be rather common in COVID-19 patients and are related to higher levels of psychological distress such as traumatic stress, depression and anxiety and worse coronavirus related outcomes including severity and mortality.Effective programs for the treatment of sleep problems, may lead to the reduction of psychological distress and vice versa and improving the sleep quality of infected patients may improve their outcomes. There is a need for appropriate and tailored management strategies and interventions across different populations including the general public and high risk groups such as Healthcare providers and COVID-19 patients including improved sleep hygiene, identification of various risk factors at individual, interpersonal, institutional and community levels and early and accurate recognition of sleep dysfunction and psychological distress.
  • 1.0K
  • 15 Dec 2021
Topic Review
Modified Pectin Binding Galectin-3 in SARS-CoV-2
Modified pectin (MP) is a bioactive complex polysaccharide that is broken down into smaller fragments of units and used as an oral dietary supplement for cell proliferation. MP is safe and non-toxic with promising therapeutic properties with regard to targeting galectin-3 (GAL-3) toward the prevention and inhibition of viral infections through the modulation of the immune response and anti-inflammatory cytokine effects. This effect of MP as a GAL-3 antagonism, which has shown benefits in preclinical and clinical models, may be of relevance to the progression of the novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in coronavirus disease 2019 patients. The outbreak of emerging infectious diseases continues to pose a threat to human health. Further to the circulation of multiple variants of SARS-CoV-2, an effective and alternative therapeutic approach to combat it has become pertinent. The use of MP as a GAL-3 inhibitor could serve as an antiviral agent blocking against the SARS-CoV-2-binding spike protein. 
  • 2.0K
  • 14 Dec 2021
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