Summary

On 11 March 2020, the World Health Organization declared COVID-19 a global pandemic, and the disease now affects nearly every country and region. Caused by SARS-CoV-2, COVID-19 continues nearly 18 months later to present significant challenges to health systems and public health in both hemispheres, as well as the economies of every country. The morbidity and mortality of the infection caused by SARS-CoV-2 has been significant, and various waves of disease outbreaks initially overwhelmed many hospitals and clinics and continue to do so in many countries. This influences everyone, and public health countermeasures have been dramatic in terms of their impact on employment, social systems, and mental health. This entry collection aims to gather diverse fields about COVID-19, including in epidemiology, public health, medicine, genetics, systems biology, informatics, data science, engineering, sociology, anthropology, nursing, environmental studies, statistics, and psychology.

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Entries
Topic Review
Homocysteine in SARS-CoV-2 Infection
Since December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread rapidly throughout the world causing health, social and economic instability. The severity and prognosis of patients with SARS-CoV-2 infection are associated with the presence of comorbidities such as cardiovascular disease, hypertension, chronic lung disease, cerebrovascular disease, diabetes, chronic kidney disease, and malignancy. Thrombosis is one of the most serious complications that can occur in patients with COVID-19. Homocysteine is a non-proteinogenic α-amino acid considered a potential marker of thrombotic diseases.
  • 771
  • 11 Jan 2023
Topic Review
Molecular Diagnosis of COVID-19
COVID-19 is no longer a global pandemic due to development and integration of different technologies for the diagnosis and treatment of the disease, technological advancement in the field of molecular biology, electronics, computer science, artificial intelligence, Internet of Things, nanotechnology, etc. has led to the development of molecular approaches and computer aided diagnosis for the detection of COVID-19. 
  • 793
  • 11 Jan 2023
Topic Review
Potential Effects of Fasting in SARS-CoV-2 Infection
Intermittent fasting is a potential complementary therapy to vaccination and antiviral therapies that not only impacts chronic disease risk but also has good evidence of an impact on infectious diseases such as COVID-19. Intermittent fasting should improve the immune response of and reduce acute hyperinflammation for unvaccinated people, strengthen immunity between vaccinations for vaccinated people, and prolong the length of time a vaccinated person can go before receiving a subsequent booster dose of the SARS-CoV-2 vaccine. A set of at least 10 biological mechanisms may be impacted by intermittent fasting in the human physiological response to SARS-CoV-2 that may reduce the severity of COVID-19 outcomes. For example, by boosting autophagy, fasting may aid the immune system to identify silently infected cells via increased degradation of viral proteins and through antigen presentation to natural killer cells and cytotoxic T cells. Intermittent fasting may also provide a constellation of mechanisms that empower a damaged human immune system to repair itself and to hunt down residual SARS-CoV-2 virus that is hiding from it in the context of both acute infection and post-acute sequelae of COVID-19. Furthermore, fasting adds no financial cost to a care plan and, when practiced safely, is available to most adults regardless of education, income, location, or ancestry. Clinical trials of intermittent fasting for reduction of COVID-19 severity are needed.
  • 2.1K
  • 06 Jan 2023
Topic Review
Treatments under Development of SARS-CoV-2
Coronaviridae is a single-strand, positive-sense, enveloped RNA virus family, circulating in many avian and mammal species hosts. In December 2019, a patient was found to have pneumonia caused by an unknown betacoronavirus. With the unbiased sample sequencing of the patient, a novel coronavirus was identified and named Severe Acute Respiratory Syndrome Coronavirus 2, SARS-CoV-2, by the International Committee on Taxonomy of Viruses (ICTV).
  • 633
  • 29 Dec 2022
Topic Review
COVID-19 Variants
This literature review aims to analyze all the vaccine candidates that went to phase II and above with the rationale behind the completion of some vaccines to phase III and why others failed to continue to phase III. Moreover, this paper will provide comprehensive information about COVID-19 infection, its symptoms, the structure of the virus, the variants that we have become aware off and how they differ. Furthermore, it will inform the literature about vaccines that developed for COVID-19 infection, vaccine vehicles and trials on vaccines. This paper shall open doors for further research and better understanding for reasons that hinder vaccines from reaching the market, which is important to be taken into consideration when developing new vaccines for viruses in the future.
  • 612
  • 01 Jan 2023
Topic Review
Autoimmune Gut Diseases and COVID-19 Vaccines
The SARS-CoV-2 pandemic raised many challenges for all patients with chronic conditions and those with autoimmune diseases, both adults and children. Autoimmune diseases are characterized by hyperreactivity of the immune system and loss of immune tolerance, which damage and destroy healthy tissues, cells, and organs.
  • 662
  • 26 Dec 2022
Topic Review
Nanostructured Materials for COVID-19 Prevention
The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has raised great concerns about human health globally. Prevention and vaccination are still the most efficient ways to slow down the pandemic and to treat SARS-CoV-2 in various aspects.
  • 565
  • 23 Dec 2022
Topic Review
Neuropsychiatric Complications of SARS-CoV-2 Infection
Beginning with the various strategies of the SARS-CoV-2 virus to invade the bodies and manifest infection, and ending with the long COVID, people are witnessing the evolving course of the disease in addition to the pandemic. Given the partially controlled course of the COVID-19 pandemic, the greatest challenge lies in managing the short- and long-term complications of COVID-19.
  • 528
  • 20 Dec 2022
Topic Review
Long COVID-19
“Long COVID-19” refers to the existence of symptoms weeks or months after contracting the SARS-CoV-2 infection, regardless of the viral state. The long COVID-19 or post COVID-19 condition is defined as the illness that arises in patients who have a history of suspected or confirmed SARS-CoV-2 infection, usually within three months of the commencement of COVID-19, with symptoms and consequences lasting at least two months.
  • 552
  • 19 Dec 2022
Topic Review
Digital Technology Adopted by Airlines during COVID-19 Pandemic
Airlines’ major adoption of digital technology during the COVID-19 crisis may have changed how customers experience the services and may affect passengers’ perceptions compared to the past. The pandemic has forced the airline industry to change and adopt new business strategies. Apart from ensuring business continuity, passengers also have higher expectations. Maintaining the same level of service standards as in the pre-pandemic era may be insufficient to retain passengers’ satisfaction with the airlines. Passengers are now more stringent with health and hygiene. New digital technology can assist the airline industry in overcoming the challenges posed by the crisis. During the pandemic period, many airlines have strengthened their digital technology capability, significantly accelerating transformation and innovation to digitalization.
  • 2.6K
  • 15 Dec 2022
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