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Topic Review
Upper Tract Urothelial Carcinoma
Upper tract urothelial carcinoma (UTUC) is a rare malignancy, occurring in 5–10% of patients diagnosed with UC, and involves the renal pelvis, calyces, or ureters. UTUC can be sporadic or hereditary as a clinical manifestation of Lynch syndrome. Therapeutic management of these patients is challenging. Following risk stratification of localized disease, patients with low-grade UTUC may undergo kidney-sparing surgery or radical nephroureterectomy (RNU) and/or chemoablation with mitomycin-c instillation to reduce recurrence.
  • 327
  • 27 Jun 2023
Topic Review
Upper Motor Neuron Disorders
Following the exclusion of potentially reversible causes, the differential for those patients presenting with a predominant upper motor neuron syndrome includes primary lateral sclerosis (PLS), hereditary spastic paraplegia (HSP), or upper motor neuron dominant ALS (UMNdALS). Differentiation of these disorders in the early phases of disease remains challenging. While no single clinical or diagnostic tests is specific, there are several developing biomarkers and neuroimaging technologies which may help distinguish PLS from HSP and UMNdALS. Recent consensus diagnostic criteria and use of evolving technologies will allow more precise delineation of PLS from other upper motor neuron disorders and aid in the targeting of potentially disease-modifying therapeutics. 
  • 438
  • 19 May 2021
Topic Review
Upper Mantle (Earth)
The upper mantle of the Earth begins just beneath the crust about 35 km (22 mi) and ends at the top of the lower mantle at 670 km (420 mi). Temperatures range from approximately 200 °C (392 °F) at the upper boundary with the crust to approximately 900 °C (1,650 °F) at the boundary with the lower mantle. Upper mantle material which has come up onto the surface is made up of about 55% olivine, 35% pyroxene and 5 to 10% of calcium oxide and aluminum oxide minerals such as plagioclase, spinel or garnet, depending upon depth.
  • 6.2K
  • 29 Sep 2022
Topic Review
Upper Cervical Chiropractors Hot Trend in New York
As the bustling metropolis of New York City continues to be at the forefront of health and wellness trends, one particular practice gaining significant attention is Upper Cervical Chiropractic. This specialized form of chiropractic care focuses on the intricate alignment of the uppermost vertebrae in the spine, known as the cervical region.
  • 94
  • 25 Jul 2024
Topic Review
Upper Airway Changes in Diverse Orthodontic Looms
Upper airway assessment is particularly important in the daily work of orthodontists, because of its close connection with the development of craniofacial structures and with other pathologies such as Obstructive Sleep Apnea Syndrome (OSAS). Rapid maxillary expansion and surgical advancement for the correction of Class II patients are associated with significant improvement in the upper airway, whereas maxillary protraction, extraction therapy, orthognathic surgery for Class III, and the use of a functional appliance have no significant impact.
  • 383
  • 24 Feb 2022
Topic Review
UPLC Technique in Pharmacy
In recent years, ultra-efficient liquid chromatography (UPLC) has gained particular popularity due to the possibility of faster separation of small molecules. This technique, used to separate the ingredients present in multi-component mixtures, has found application in many fields, such as chemistry, pharmacy, food, and biochemistry. It is an important tool in both research and production. UPLC created new possibilities for analytical separation without reducing the quality of the obtained results. This technique is therefore a milestone in liquid chromatography. Thanks to the increased resolution, new analytical procedures, in many cases, based on existing methods, are being developed, eliminating the need for re-analysis. Researchers are trying to modify and transfer the analytical conditions from the commonly used HPLC method to UPLC. This topic may be of strategic importance in the analysis of medicinal substances.
  • 569
  • 07 Dec 2022
Topic Review
Uplay
Uplay is a digital distribution, digital rights management, multiplayer and communications service developed by Ubisoft to provide an experience similar to the achievements/trophies offered by various other game companies. The service is provided across various platforms. Uplay is used exclusively by first-party Ubisoft games, and although some third-party ones are sold through the Uplay store, they do not use the Uplay platform. Responses to the platform have been generally negative, with coverage comparing it negatively to its competitors and calling it the worst part of Ubisoft's games.
  • 1.1K
  • 30 Nov 2022
Topic Review
Upfront Chemotherapy Followed by SBRT in Pancreatic Cancer
Multimodality therapy involving stereotactic body radiation therapy (SBRT) is safe and feasible in older patients with localized pancreatic cancer. Surgical resection was associated with improved clinical outcomes. As such, older patients who complete chemotherapy should not be excluded from aggressive local therapy when possible.
  • 345
  • 14 Jan 2022
Topic Review
Updating Phospholipase A2 Biology
The phospholipase A2 (PLA2) superfamily contains more than 50 enzymes in mammals that are subdivided into several distinct families on a structural and biochemical basis. In principle, PLA2 has the capacity to hydrolyze the sn-2 position of glycerophospholipids to release fatty acids and lysophospholipids, yet several enzymes in this superfamily catalyze other reactions rather than or in addition to the PLA2 reaction. PLA2 enzymes play crucial roles in not only the production of lipid mediators, but also membrane remodeling, bioenergetics, and body surface barrier, thereby participating in a number of biological events. Accordingly, disturbance of PLA2-regulated lipid metabolism is often associated with various diseases.
  • 1.4K
  • 17 Nov 2020
Topic Review
Updates in Culture-Negative Endocarditis
Blood culture-negative infective endocarditis (BCNE) is a challenging condition associated with significant morbidity and mortality.
  • 228
  • 24 Aug 2023
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