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Topic Review
Neonatal Early-Onset Sepsis
Neonatal early-onset sepsis (EOS) is defined as an invasive infection that occurs in the first 72 h of life. The incidence of EOS varies from 0.5–2 per 1000 live births in developed countries, up to 9.8 per 1000 live births in low resource settings, generating a high mortality rate, especially in extremely low birth weight neonates. Clinical signs are nonspecific, leading to a late diagnosis and high mortality. Currently, there are several markers used for sepsis evaluation, such as hematological indices, acute phase reactants, cytokines, which by themselves do not show acceptable sensitivity and specificity for the diagnosis of EOS in neonates. Newer and more selective markers have surfaced recently, such as presepsin and endocan, but they are currently only in the experimental research stages.
  • 1.8K
  • 28 Sep 2021
Topic Review
Eugenol-based O/W Emulsion by Low-energy Emulsification
Emulsions are systems formed by two immiscible liquids, one of which is dispersed in the other as droplets with a relative stability. These have multiple applications, among them, in the formulation of pharmaceutical and cosmetic products. Its preparation requires generating a large interfacial area, which is usually attained by using the physicochemical formulation know-how on surfactant-oil-water (SOW) systems. Among the applications in the pharmaceutical industry, topical creams, and emulsions for intravenous and for oral administration can be found.  Eugenol can be extracted from cloves (Syzygium aromaticum) by various methods, including steam distillation, hydrodistillation and Soxhlet extraction. Furthermore, emulsions based on eugenol can be obtained for a variety of applications, including as topical and oral anesthetic. Nanoemulsions can be formulated with a mixture of non-ionic surfactants Span 20/Tween 80 at an HLB of 11 to 13 and a total surfactant concentration of 4%, using the dilution phase transition method (so-called spontaneous emulsification) to attain stable O/W eugenol-based emulsions. Paraffin oil/eugenol ratio of 4/1 can be used to reach a final emulsion internal oil phase content of 10% with 4% surfactant and 86% aqueous phase. Different polymers are used as viscosifiers, including carboxymethylcellulose. Under these conditions, eugenol-based emulsions with an average droplet size of less than 2 μm can be attained, with topical and oral anesthetic characteristics.
  • 1.8K
  • 03 Apr 2022
Topic Review
Myrica esculenta
Myrica esculenta (Myricaceae) is a popular medicinal plant most commonly found in the sub-tropical Himalayas. It is widely used in folk medicine to treat several ailments such as asthma, cough, chronic bronchitis, ulcers, inflammation, anemia, fever, diarrhea, and ear, nose, and throat disorders. Due to its multidimensional pharmacological and therapeutic effects, it is well recognized in the ayurvedic pharmacopeia.
  • 1.8K
  • 19 Apr 2022
Topic Review
Body Image Disturbance
Body image disturbance (BID) is a common symptom in patients with eating disorders. The onset is mainly attributed to patients with anorexia nervosa who persistently tend to subjectively discern themselves as average or overweight despite adequate, clinical grounds for a classification of being severely underweight. The symptom is an altered perception of one's body and a severe state of bodily dissatisfaction characterizing the body image disturbance. It is included among the diagnostic criteria for anorexia nervosa in DSM-5 (criterion C). The disturbance is associated with significant bodily dissatisfaction and is a source of severe distress, often persisting even after seeking treatment for an eating disorder, and is regarded difficult to treat. Thus, effective body image interventions could improve the prognosis in patients with ED, as experts have suggested. Unfortunately, there is no hard evidence that current treatments for body image disturbance effectively reduce eating disorders' symptoms. Furthermore, pharmacotherapy is ineffective in reducing body misperception and it has been used to focus on correlated psychopathology (e.g., mood or anxiety disorders). However, to date, research and clinicians are developing new therapies as virtual reality experiences, mirror exposure or multisensory integration body techniques, which have shown some extent of efficacy.
  • 1.8K
  • 22 Nov 2022
Topic Review
Fruit by-Products
Fruit by-Products deals with the bioactive compounds present in the by-products generated by the fruit processing industry with large amounts. These bioactive compounds are mainly dietary fibres, phenolic compounds, proteins and lipids. They have significant chemical, physical and biological properties which make fruits by-products a good source for new supplements in food products having important effect on intestinal function. 
  • 1.8K
  • 03 Dec 2020
Topic Review
Entoptic Phenomenon
Entoptic phenomena (from grc ἐντός (entós) 'within', and ὀπτικός (optikós) 'visual') are visual effects whose source is within the human eye itself. (Occasionally, these are called entopic phenomena, which is probably a typographical mistake.) In Helmholtz's words: "Under suitable conditions light falling on the eye may render visible certain objects within the eye itself. These perceptions are called entoptical."
  • 1.8K
  • 02 Nov 2022
Topic Review
Biogenic Synthesis
Recent advances in the research of therapeutic plant and nanotechnology has been on the increase. Significantly in the green synthesis of metallic nanoparticles (MNPs) because of its numerous gains over conventional methods. Biological conventions for synthesis of silver nanoparticles (AgNPs) and gold nanoparticles (AuNPs) are through the use of nature’s biolaboratory such as plant, microorganisms, alga, carbohydrates and biopolymers . Medicinal plant is a choice natural reserve for different phytochemicals in the synthesis of biogenic MNPs. Thus, they are deemed a green, sustainable, and efficient route for the biosynthesis of MNPs owing to their benign and environmentally friendly nature. In this review we discussed the mode of synthesis strategies and the proposed mechanism of biocidal antibacterial activity of MNPs.  The focus is on the synthesis and possible antibacterial mechanism of specific MNPs such as silver (Ag), gold (Au) and their bimetallic synthesized from plants. This is to give a synergistic view of the efficacy of plant mediated MNPs for the prospect of antibiotic development.
  • 1.8K
  • 17 Nov 2020
Topic Review Peer Reviewed
Ionic Liquids in Drug Delivery
Ionic liquids (ILs) are molten salts composed of a large organic cation and an organic/inorganic anion. The large dimensions of their ions lead to charge dispersion, which makes difficult the formation of a regular crystalline structure. Due to their unique properties, ILs have been applied in the crystallization of active pharmaceutical ingredients (APIs), as solvents, co-solvents and emulsifiers in drug formulations, as pharmaceuticals (API-ILs) aiming liquid therapeutics, and in the development and/or improvement of drug-delivery-based systems.
  • 1.7K
  • 13 Apr 2022
Topic Review
Polyurethanes in Biomedicine
Due to their mechanical properties, ranging from flexible to hard materials, polyurethanes (PUs) have been widely used in many industrial and biomedical applications. PU characteristics, along with their biocompatibility, make them successful biomaterials in short and medium time applications.  The most important biomedical applications of PUs include antibacterial surfaces and catheters, blood oxygenators, dialysis devices, stents, cardiac valves, vascular prostheses, bioadhesives/surgical dressings/pressure sensitive adhesives, drug delivery systems, tissue engineering scaffolds and electrospinning, nerve generation, pacemaker lead insulation and coatings for breast implants. The diversity of polyurethane properties due to the ease of bulk and surface modification plays a vital role in their applications. 
  • 1.8K
  • 28 Oct 2020
Topic Review
Angiogenesis and de novo Arteriogenesis
Arteriogenesis supply oxygen and nutrients in tumor microenvironment (TME), which may play an important role in tumor growth and metastasis. Current anti-angiogenetic targeted treatments have not shown substantial clinical benefits and they are poorly tolerated, and even lead to more malignant relapse. The heterogeneity of tumor-associated endothelial cells (TAECs) and tumor vasculature may be important and should be appreciated in therapeutic targeting the TME. In this regard, the de novo arteriogenesis within the TME may be associated with tumor progression, stemness of cancer stem-like cells (CSCs) and therapeutic resistance and relapse. Targeting tumor arteriogenesis may thus be a potential novel therapeutic target. Specifically, targeting the FoxO1-CD36-Notch pathway could show the clinical potential by acting on arteriolar niche and CSCs at the same time in a variety of cancers including neuroendocrine cancers, breast cancers, lung cancers and malignant melanoma.
  • 1.8K
  • 29 Oct 2020
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