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Topic Review
Antiparasitic Mebendazole for the Treatment of Brain Cancers
Cancer ranks as a leading cause of death and a significant barrier to increasing life expectancy in every country. According to estimates from the World Health Organization (WHO) in 2019, cancer is the first or second leading cause of death before age 70 in 112 of 183 countries and ranks third or fourth in 23 countries. Tumor treatments usually consist of chemotherapy, radiotherapy, surgery, targeted therapy, immunotherapy, and endocrine therapy that can be used individually or in combination, depending on the stage and type of tumor and diagnosis. Several factors reduce the practical improvement of a cancer patient’s prognosis. Drug-untreatable targets, chemoresistance, tumor heterogeneity, and metastases formation are significant barriers to the effective cure of cancer patients. Despite intense preclinical and clinical research efforts, the survival rate of patients suffering from the most aggressive cancer types has not yet improved, mainly due to therapeutic failure. Moreover, nearly all anticancer medications on the market have serious adverse effects; therefore, new, safer anticancer drugs are desirable.
  • 2.1K
  • 19 Jan 2023
Topic Review
Lymphatic Drainage of Renal Tissues
Acute kidney injury (AKI), especially if recurring, represents a risk factor for future chronic kidney disease. In intensive care units, increased intra-abdominal pressure is well-recognized as a significant contributor to AKI. Renal interstitial pressure changes synchronously to renal perfusion pressure. The renal parenchyma is primarily drained by the urine conducting and renal venous system. The renal lymphatic system can also contribute to renal compartment syndrome, the functional changes in the lymphatic flow was not investigated in connection with pneumo-peritoneum.
  • 2.1K
  • 17 May 2022
Topic Review
Acquired Cytomegalovirus Infection Hearing Loss
Congenital cytomegalovirus (CMV) infection induces a clinical syndrome usually associated with hearing loss. However, the effect of acquired CVM infection in adults and children has not been clearly defined.
  • 2.1K
  • 28 Dec 2020
Topic Review
Antibody Conjugated Polymeric Nanoparticles
Nanoparticles (NPs) are promising drug delivery systems (DDS) for identifying and treating cancer. Active targeting NPs can be generated by conjugation with ligands that bind overexpressed or mutant cell surface receptors on target cells that are poorly or not even expressed on normal cells. Receptor-mediated endocytosis of the NPs occurs and the drug is released inside the cell or in the surrounding tissue due to the bystander effect. Antibodies are the most frequently used ligands to actively target tumor cells. In this context, antibody-based therapies have been extensively used in HER2+ breast cancer.
  • 2.1K
  • 29 Oct 2020
Topic Review
Mindfulness
Mindfulness is the psychological process of purposely bringing one's attention to experiences occurring in the present moment without judgment which one develops through the practice of meditation and through other training. Mindfulness derives from sati, a significant element of Buddhist traditions, and based on Zen, Vipassanā, and Tibetan meditation techniques. Though definitions and techniques of mindfulness are wide-ranging, Buddhist traditions explain what constitutes mindfulness such as how past, present and future moments arise and cease as momentary sense impressions and mental phenomena. Individuals who have contributed to the popularity of mindfulness in the modern Western context include Thích Nhất Hạnh (1926– ), Herbert Benson (1935– ), Jon Kabat-Zinn (1944– ), and Richard J. Davidson (1951– ). Clinical psychology and psychiatry since the 1970s have developed a number of therapeutic applications based on mindfulness for helping people experiencing a variety of psychological conditions. Mindfulness practice has been employed to reduce depression, to reduce stress, anxiety, and in the treatment of drug addiction. Programs based on mindfulness models have been adopted within schools, prisons, hospitals, veterans' centers, and other environments, and mindfulness programs have been applied for additional outcomes such as for healthy aging, weight management, athletic performance, helping children with special needs, and as an intervention during the perinatal period. Clinical studies have documented both physical- and mental-health benefits of mindfulness in different patient categories as well as in healthy adults and children. Research studies have shown a positive relationship between trait mindfulness (see below) and psychological health. The practice of mindfulness appears to provide therapeutic benefits to people with psychiatric disorders, including moderate benefits to those with psychosis. Studies also indicate that rumination and worry contribute to a variety of mental disorders, and that mindfulness-based interventions can reduce both rumination and worry. Further, the practice of mindfulness may be a preventive strategy to halt the development of mental-health problems. There is also evidence that suggest engaging in mindfulness meditation may influence physical health. For example, the psychological habit of repeatedly dwelling on stressful thoughts (i.e., rumination) appears to intensify the physiological effects of the stressor (as a result of the continual activation of the sympathetic nervous system and the hypothalamus-pituitary-adrenal axis) with the potential to lead to physical health related clinical manifestations. Studies indicate that mindfulness meditation, which brings about reductions in rumination, may alter these biological clinical pathways. Further, research indicates that mindfulness may favourably influence the immune system as well as inflammation,Cite error: Closing missing for tag
  • 2.1K
  • 12 Oct 2022
Topic Review
Dietary Fibre from Virgin Sugarcane
Prebiotic dietary fibre (DF) has gained significant research attention owing to its reported potential in conferring health benefits through modulating gut microbiota composition and their metabolic activities. Complex dietary fibres from whole-plant sources are becoming recognised as vital parameters in influencing the gut microbial diversity in contrast to isolated or purified DF forms. In this entry, we review the recent evidence from in-vivo and clinical studies to support the significant prebiotic capacity of whole-plant virgin processed sugarcane fibre in countering gut inflammation and undesirable digestive symptoms.
  • 2.1K
  • 16 Mar 2021
Topic Review
Immigrant Paradox
The immigrant paradox is that recent immigrants often outperform more established immigrants and non-immigrants on a number of health-, education-, and conduct- or crime-related outcomes, despite the numerous barriers they face to successful social integration. According to the UN, the number of first-generation immigrants worldwide is 244 million. These large-scale population changes worldwide have led many scholars, across fields, to study the acculturation and adjustment of immigrants to their new homes. Specifically, researchers have examined immigrant experiences as they pertain to educational attainment, mental and physical health, and conduct/crime. Researchers have tried to understand why later generations seem to perform less well than their forebears. They have found that it can be explained by non-optimal methodology and differences in the way generations are modified by the host culture.
  • 2.1K
  • 29 Nov 2022
Topic Review
Biological Half-life
The biological half-life of a biological substance is the time it takes for half to be removed by biological processes. This concept is used when the rate of removal is roughly exponential. It is often denoted by the abbreviation [math]\displaystyle{ t_{\frac{1}{2}} }[/math]. This is used to measure the removal of things such as metabolites, drugs, and signalling molecules from the body. Typically, the biological half-life refers to the body's natural cleansing through the function of the liver and through the excretion of the measured substance through the kidneys and intestines. In a medical context, half-life explicitly describes the time it takes for the blood plasma concentration of a substance to halve (plasma half-life) its steady-state when circulating in the full blood of an organism. This measurement is useful in medicine and pharmacology because it helps determine how much of a drug needs to be taken and how frequently it needs to be taken if a certain average amount is needed constantly. In contrast, the stability of a substance direct in plasma is described with plasma stability that is essential to ensure accurate analysis of drugs in plasma and for Drug discovery. The relationship between the biological and plasma half-lives of a substance can be complex depending on the substance in question, due to factors including accumulation in tissues (protein binding), active metabolites, and receptor interactions.
  • 2.1K
  • 17 Nov 2022
Topic Review
Metabolism and Role of Creatine
Creatine is a key player in  energy metabolism of excitable cells. This is an essential outline of its role and procurement by the organism, adapted by the author (Balestrino M, University of Genoa, Italy) from his Open Access paper  Role of Creatine in the Heart: Health and Disease, that was published in Nutrients, 2021; 13(4):1215. https://doi.org/10.3390/nu13041215.
  • 2.1K
  • 27 Apr 2021
Topic Review
GDM
Gestational diabetes mellitus (GDM) is a pregnancy complication first detected in the second or third trimester in women that did not show evident glucose intolerance or diabetes before gestation. 
  • 2.1K
  • 27 May 2021
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