Topic Review
Ireland's Experience of Covid-19 and Eating Disorders
Irish society went into one of the most stringent lockdowns in March 2020 due to the COVID-19 pandemic, and barring a few weeks, remains highly restricted at time of writing. This has produced a wide range of challenges for those affected by eating disorders, as well as treatment services and Bodywhys, The Eating Disorders Association of Ireland. Current research indicates that COVID-19 has impacted across three key areas—the experience of those with an eating disorder, the experience of service provision, and the impact on the family situation.
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  • 29 Mar 2022
Topic Review
CAD/CAM Diagnostic Esthetic Functional Splint (DEFS)
DEFS (Diagnostic Esthetic Functional Splint), namely CAD/CAM manufactured, “snap-retained”, tooth-colored splints available by materials exhibiting a certain degree of elasticity (like polycarbonates or acetal resins) for restoring function, esthetics and occlusion in several clinical situations, before or as an intermediate alternative to undergoing the final treatment.
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  • 29 Mar 2022
Topic Review
Effect of Exercise on Brain Health
It has been well established in epidemiological studies and randomized controlled trials that habitual exercise is beneficial for brain health, such as cognition and mental health. Generally, it may be reasonable to say that the physiological benefits of acute exercise can prevent brain disorders in late life if such exercise is habitually/chronically conducted. 
  • 343
  • 29 Mar 2022
Topic Review
VISTA, PDL-L1, and BRAF—Markers in Prognosis of Melanoma
Melanoma is currently known as one of the most aggressive malignant tumors. T cell Activation (VISTA) is a novel target that is considered to be highly important in determining the invasive potential and treatment response of a melanoma. Programmed death-ligand 1 (PD-L1) is a marker with whose importance has been revealed in multiple types of malignancies.
  • 438
  • 29 Mar 2022
Topic Review
Sex Disparity in Cardiovascular Disease
Among cardiovascular diseases, acute myocardial infarction (AMI) shows significant differences in occurrence rate, prognosis and efficacy of treatment between male and female patients. Genomics and epigenomics approaches together with epidrugs design and drug repositioning could fill the sex-gap.
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  • 29 Mar 2022
Topic Review
β-Carotene Supplementation and Risk of Cardiovascular Disease
β-carotene is widely available in plant-based foods. β-carotene supplementation had no beneficial effects on cardiovascular disease (CVD) incidence and potential harmful effects on CVD mortality. 
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  • 29 Mar 2022
Topic Review
History of Human Movement Studies
Knowing the genesis of ideas is important to understand why we are studying a topic. This topic review is an historical excursus about the origin of movement studies, following the ideas of Aristotle until positivism. The main ideas at the origin of biomechanical studies are historically reviewed, with special focus on the enlightment era. Key figures at the origin of movement studies were presented, together with the main ideas they introduced, most of which are still at the basis of modern research in the field of biomechanics. The entry can be of interest for all professionals working in the field of human and animal movement studies.
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  • 29 Mar 2022
Topic Review
Plant-Based Dietary Program in Patients with Diabetes
Dietary choices play a key role in insulin sensitivity among diabetes patients. An 8-week pilot study was conducted to evaluate whether a mostly plant-based dietary program will lead to improvement in biochemical markers in adults with diabetes. 
  • 432
  • 29 Mar 2022
Topic Review
The Role of Insulin-like Growth Factor-1
The anterior pituitary also referred to as the adenohypophysis, originates from the oral ectoderm during embryonic development. It is enclosed by a network of blood capillaries originating from the hypothalamus, as a part of the hypophyseal portal system, responsible for transporting hormones from the hypothalamus to the anterior pituitary and from the anterior pituitary to the circulatory system. Hence, the hypophyseal portal system prevents hypothalamic hormones from entering directly into the circulation..
  • 417
  • 29 Mar 2022
Topic Review
Exercise Mitigates Pathological Liver Changes
Exercise attenuates pathological changes in the liver induced by high-fat diets. The underlying mechanisms might be related to Nuclear factor erythroid-2-related factor 2 (NRF2) and mediated by SIRT1/AMPK signaling. 
  • 544
  • 29 Mar 2022
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