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Topic Review
Sex Differences in Substance Use, Prevalence, Pharmacological Therapy
Sex differences are poorly studied within the field of mental health, even though there is evidence of disparities (with respect to brain anatomy, activation patterns, and neurochemistry, etc.) that can significantly influence the etiology and course of mental disorders. Girls with ADHD are more at risk of substance use than boys, although there was no consensus on the prevalence of dual disorders. Girls are less frequently treated because of underdiagnosis and because they are more often inattentive and thereby show less disruptive behavior. Together with increased impairment in cognitive and executive functioning in girls, the aforementioned could be related to greater substance use and poorer functioning, especially in terms of more self-injurious behavior; and early diagnosis and treatment of ADHD, especially in adolescent girls, is essential to prevent early substance use, the development of SUD, and suicidal behavior.
  • 292
  • 27 May 2022
Topic Review
Smoking a Dangerous Addiction
Despite growing knowledge of the adverse effects of cigarette smoking on general health, smoking is one of the most widely prevalent addictions around the world. Globally, about 1.1 billion smokers and over 8 million people die each year because of cigarette smoking. Smoking acts as a source for a variety of oral and systemic diseases. Various periodontal issues such as increased pocket depth, loss of alveolar bone, tooth mobility, oral lesions, ulcerations, halitosis, and stained teeth are more common among smokers. This systematic review was conducted according to the guidelines from PRISMA, and research articles were retrieved from the Web database sources on 31 May 2021. The quality of research articles was ensured by the type of evidence from combined schema incorporating as schema-13 evidence type description, Cochrane health promotion and public health field (CHPPHF), and the health gains notation framework-14 screening question for quality assessment of qualitative and quantitative studies. Smokers have been found to have bleeding on probing, periodontal pockets, and clinical attachment loss compared to nonsmokers. Oral and respiratory cancers are among the most lethal known diseases caused by cigarette smoking and other commonly occurring sequelae such as stained teeth, periodontal diseases, etc. 
  • 291
  • 29 Oct 2021
Topic Review
Population Immunity
Herd immunity is a population condition where the pathogen dispersion between the community members is difficult or impossible because when an infected individual appears, the individuals surrounding her/him are immune against the pathogen, so they do not get infected and do not transmit the pathogen to other susceptible individuals. 
  • 291
  • 20 Apr 2023
Topic Review
Mycotoxins in the Context of HBM4EU Initiative
Mycotoxins are natural metabolites produced by fungi that contaminate food and feed worldwide. They can pose a threat to human and animal health, mainly causing chronic effects, e.g., immunotoxic and carcinogenic. Due to climate change, an increase in European population exposure to mycotoxins is expected to occur, raising public health concerns. This urges researchers to assess the current human exposure to mycotoxins in Europe to allow monitoring exposure and prevent future health impacts. The mycotoxins deoxynivalenol (DON) and fumonisin B1 (FB1) were considered as priority substances to be studied within the European Human Biomonitoring Initiative (HBM4EU) to generate knowledge on internal exposure and their potential health impacts.
  • 290
  • 08 Dec 2022
Topic Review
In Vitro Digestion of Persimmon and Derived Products
In vitro digestion is widely used to study the gastrointestinal behavior of foods. It reproduces the human physiological gastrointestinal process in the laboratory in a controlled and reproducible way.
  • 290
  • 19 Jan 2022
Topic Review
Immune Checkpoint Inhibitor-Induced Hypophysitis
Immune checkpoint inhibitors (ICIs) are a new type of antitumor drug which can achieve antitumor goals by blocking the binding of immune checkpoints to their ligands, thereby enhancing the activity of T cells. Meanwhile, ICIs block the binding of immune checkpoints to their ligands, disrupting the immune tolerance of T cells to self-antigens, which may lead to a series of immune-related adverse events (irAEs). Immune checkpoint inhibitor-induced hypophysitis (IH) is a relatively rare irAE. Due to the lack of specificity in clinical manifestations, it is difficult to accurately diagnose IH in a timely manner in clinical practice. However, the risk of adverse events, especially IH, for patients receiving ICIs has not been adequately investigated. Missed or delayed diagnosis may lead to poor prognosis or even adverse clinical outcomes.
  • 289
  • 05 Jul 2023
Topic Review
Decrease Death Rate of Neonates
Neglected diseases still kill and disable too many, but no age group has in this regard received less attention than newborns. A newborn or neonate is a human from age 0 to 28 days. Worldwide, their contribution to death and disease is overwhelming and unequaled by any condition, while at the same time, its prevention and treatments are simple, relatively cheap, and efficient. 
  • 289
  • 12 May 2022
Topic Review
OTFT Monitoring in Complex Body Fluid Environments
People are becoming more concerned about their physical health and putting forward higher requirements for an early and painless diagnosis of diseases. Traditional methods, such as surface plasmon resonance (SPR), enzyme-linked immunosorbent assay (ELISA), surface-enhanced raman spectroscopy (SERS), and colorimetric methods have been used for the detection of biomarkers with high selectivity and sensitivity; however, these methods still need to be further improved for immediate and rapid diagnosis. Herein, organic thin-film transistors (OTFTs)-based biosensors offer the advantages of good flexibility, low-cost fabrication, reasonable sensitivity, and great biocompatibility for efficient determination of biomarkers in complex samples, including saliva, sweat, urine, and blood, respectively, exhibiting great potential in early disease diagnosis and clinical treatment.
  • 288
  • 11 Apr 2023
Topic Review
The Mediterranean Diet
A cornerstone of any healthy lifestyle program is the inclusion of a balanced diet that can prevent various diseases, including cardiovascular conditions. The Mediterranean diet (MD) has become one of the most studied and widely reported diets and has received a lot of attention. The MD is a dietary plan based on Crete’s traditional eating habits. 
  • 289
  • 25 Oct 2023
Topic Review
Magnetic Resonance Imaging Methods in Health and Disease
Magnetic Resonance Imaging (MRI) is the modality of choice for a vast range of pathologies but also a sensitive probe into human physiology and tissue function. For this reason, several methodologies have been developed and continuously evolve in order to non-invasively monitor underlying phenomena in human adipose tissue that were difficult to assess in the past through visual inspection of standard imaging modalities.
  • 289
  • 21 Dec 2023
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