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Topic Review
Physical Activity in Cardiometabolic Disease
Cardiometabolic disease begins with insulin resistance and then progresses to the clinically identifiable high-risk states of metabolic syndrome and prediabetes, before it leads to type 2 diabetes (T2DM) and cardiovascular disease (CVD). In low-to-middle-income countries (LMICs), the burden attributable to non-communicable disease (including CVD and T2DM) increased from 37.8% of total disability-adjusted life years (DALYs) in 1990 to 66.0% in 2019, with a similar pattern in upper-middle-income countries as well. Cardiometabolic disease imposes a large financial burden on patients and households, while increasing vulnerability to poverty.
  • 352
  • 06 Dec 2021
Topic Review
BHLHE41/DEC2 in Non-Small Lung Cancer Development
The circadian rhythm-related genes BHLHE40/DEC1 and BHLHE41/DEC2 have various functions under different cell and tissue conditions. BHLHE41/DEC2 has been reported to be both a cancer-suppressive and an oncogenic gene during cancer development. The effects of BHLHE41/DEC2 on differentiation have been examined using Bhlhe41/Dec2 knockout mice and/or in vitro differentiation models, and research has been conducted using genetic analysis of tumor cells, in vitro analysis of cancer cell lines, and immunohistochemical studies of the clinical samples.
  • 352
  • 08 Aug 2023
Topic Review
Exploring Olive Pomace for Skincare Applications
The olive oil industry generates a large amount of liquid and semi-solid by-products such as olive pomace. Their phytotoxicity impairs safe disposal, so valorization strategies that promote by-product reuse are needed, which may include skincare products. Hydroxytyrosol is the main phenolic compound present in olive pomace and possesses biological effects that make it a desirable active compound for cosmetic formulations such as antioxidant and anti-aging activities as well as photoprotector, depigmenting, antimicrobial and anti-inflammatory actions. Other compounds present in olive pomace can also have functional properties and skin-related benefits. However, the application of this by-product can be a challenge in terms of formulation’s design, stability, and proven efficacy, so appropriate methodologies should be used to validate its incorporation and may include extraction and further encapsulation of bioactive compounds in order to achieve effective and aesthetic appealing skincare products.
  • 352
  • 17 Mar 2023
Topic Review
Human Milk Microbiota on Maternal and Child Health
Human milk (HM) is considered the most complete food for infants as its nutritional composition is specifically designed to meet infant nutritional requirements during early life. HM also provides numerous biologically active components, such as polyunsaturated fatty acids, milk fat globules, IgA, gangliosides or polyamines, among others; in addition, HM has a “bifidogenic effect”, a prebiotic effect, as a result of the low concentration of proteins and phosphates, as well as the presence of lactoferrin, lactose, nucleotides and oligosaccharides. Recently, has been a growing interest in HM as a potential source of probiotics and commensal bacteria to the infant gut, which might, in turn, influence both the gut colonization and maturation of infant immune system. Our review aims to address practical approaches to the detection of microbial communities in human breast milk samples, delving into their origin, composition and functions. Furthermore, we will summarize the current knowledge of how HM microbiota dysbiosis acts as a short- and long-term predictor of maternal and infant health. Finally, we also provide a critical view of the role of breast milk-related bacteria as a novel probiotic strategy in the prevention and treatment of maternal and offspring diseases.
  • 351
  • 11 Nov 2021
Topic Review
Urological Manifestations of Systemic Vasculitides
Vasculitides are specific inflammations of the blood vessel wall that can take place in any organ system of the human body. They may occur as a primary process (primary systemic vasculitides, PSV) or may be secondary to another underlying disease.
  • 351
  • 20 Dec 2021
Topic Review
Usage of Telerehabilitation
Telerehabilitation is an alternative platform of telecommunication-based practice that could provide alternatives in delivering health education and care for clients or individuals either in clinical, community or home care settings.
  • 351
  • 26 Apr 2022
Topic Review
Management of Cervical Cancer in Sub-Saharan Africa
Cervical cancer (CC) is the most common viral infection of the reproductive tract and in Sub-Saharan Africa (SSA), its morbidity and mortality rates are high. High HPV vaccine coverage can be achieved using the class school-based strategy with opt-out consent form process. Barriers to CC screening uptake included lack of knowledge and awareness and unavailability of screening services. The reasons for late-stage presentation at diagnosis were unavailability of screening services, delaying whilst using complementary and alternative medicines and poor referral systems. The challenges in chemotherapy included unavailability and affordability, low survival rates, treatment interruption due to stock-outs as well as late presentation. Major challenges on radiotherapy were unavailability of radiotherapy, treatment interruption due to financial constraints, and machine breakdown and low quality of life.
  • 351
  • 05 Aug 2022
Topic Review
Qualitative Methods in Translational Health
Translational health research is an interdisciplinary field aimed at bridging the gap between basic science studies, preventative studies, and clinical practice to improve health-related outcomes. Qualitative research methods provide a unique perspective on the emotional, social, cultural, and contextual factors that influence health and healthcare and thus are recognized as valuable tools for translational health research. This approach can be embedded within a mixed method design which complements the quantitative findings.
  • 352
  • 09 Oct 2023
Topic Review
Executive Functions and Theory of Mind in Aging
Social cognition is essential for maintaining relationships throughout life, with Theory of Mind (ToM) as its central component. ToM encompasses both cognitive and affective processes, enabling individuals to decipher concealed social cues and make moral judgments within various social contexts. ToM is a current topic of interest investigated in diverse age-related conditions, such as Mild Cognitive Impairment (MCI), a transitional stage between healthy and pathological aging. Recognizing ToM difficulties is crucial, as they can significantly impact decision-making and social interactions while also serving as valuable indicators for tracking disease progression. However, assessing ToM poses challenges, given the variety of available tests and the ongoing debate about its connection with other cognitive abilities. Existing literature suggests that executive functions (EF) can influence ToM performance, but only a few studies have delved into this aspect deeply. Improving the understanding of the dynamics of ToM, its interaction with age-related changes, and its possible variations in MCI is critical to promoting social well-being and cognitive health in older people.
  • 350
  • 25 Oct 2023
Topic Review
Upper Airway Changes in Diverse Orthodontic Looms
Upper airway assessment is particularly important in the daily work of orthodontists, because of its close connection with the development of craniofacial structures and with other pathologies such as Obstructive Sleep Apnea Syndrome (OSAS). Rapid maxillary expansion and surgical advancement for the correction of Class II patients are associated with significant improvement in the upper airway, whereas maxillary protraction, extraction therapy, orthognathic surgery for Class III, and the use of a functional appliance have no significant impact.
  • 350
  • 24 Feb 2022
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