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Topic Review
Congenital Afibrinogenemia and Hypofibrinogenemia
Congenital fibrinogen disorders are rare pathologies of the hemostasis, comprising quantitative and qualitative disorders. The clinical phenotype is highly heterogeneous, being associated with bleeding, thrombosis, or absence of symptoms. Afibrinogenemia and hypofibrinogenemia are the consequence of mutations in the homozygous, heterozygous, or compound heterozygous state in one of three genes encoding the fibrinogen chains, which can affect the synthesis, assembly, intracellular processing, stability, or secretion of fibrinogen. In addition to standard coagulation tests depending on the formation of fibrin, diagnostics also includes global coagulation assays, which are effective in monitoring the management of replacement therapy. Genetic testing is a key point for confirming the clinical diagnosis. The identification of the precise genetic mutations of congenital fibrinogen disorders is of value to permit early testing of other at risk persons and better understand the correlation between clinical phenotype and genotype.
  • 549
  • 02 Mar 2022
Topic Review
Neurobehavioral Phenotype and Dysexecutive Syndrome of Preterm Children
The neurodevelopmental outcome of the premature infant is characterized by a set of minor-to-moderate dysfunctions in the developmental fields (language, praxis, executive, behavioral and attention disorders, social interaction disorders, etc.). These dysfunctions tend to cumulate, even to potentiate, which impacts school learning and the daily life of these children and their parents. Executive functions, such as high-level cognitive operations, play a preponderant role in learning and social adaptation via the regulation of children’s behavior and emotions. Thus, the notion of executive dysfunctions as an underlying mechanism of neurodevelopmental difficulties in VP children is now well documented. Executive deficit is central to the neurodevelopmental phenotype of preterm infants and their learning difficulties, both from a cognitive and a behavioral or social point of view.
  • 549
  • 25 Mar 2022
Topic Review
Effect of Healthy Food/Beverages in Hospital Food Environment
The quality of the hospital food environment varies within and between facilities. Hospital visitors and employees are generally receptive to food environment interventions and a variety of designs can be used to improve the hospital food environment and increase the proportion of healthy purchases. The overall quality of hospital food environments varies. Educational, labelling, financial and choice architecture interventions were shown to improve the hospital food environment and/or dietary intake of consumers.
  • 549
  • 21 Apr 2022
Topic Review
Spiritual Needs in Post-Secular Contexts
It was found that it can be challenging to incorporate spiritual care in daily practice, not least in post-secular, culturally entwined, and pluralist contexts.
  • 549
  • 01 Mar 2022
Topic Review
Postpartum Relapse in Patients with Bipolar Disorder
Pregnancy and postpartum are vital times of greater vulnerability to suffer a decompensation of bipolar disorder (BD).
  • 549
  • 01 Aug 2022
Topic Review
Bacteria in Healthcare Units
Healthcare units consist of numerous people circulating daily, such as workers, patients, and companions, and these people are vehicles for the transmission of microorganisms, such as bacteria. Bacteria species may have different allergenic, pathogenic, infectious, or toxic properties that can affect humans.
  • 548
  • 07 Mar 2022
Topic Review
Artisanal Beers
Beer is an alcoholic beverage frequently consumed globally. Special beers, known as artisanal, are progressively gaining consumer preference, opening up competition, and acquiring more space in the market.
  • 547
  • 01 Aug 2022
Topic Review
Effects of Methylmercury plus Ethanol Exposure on Emotionality
Mercury is a heavy metal found in organic and inorganic forms that represents an important toxicant with impact on human health. Mercury can be released in the environment by natural phenoms (i.e., volcanic eruptions), industrial products, waste, or anthropogenic actions (i.e., mining activity). 
  • 547
  • 10 Dec 2021
Topic Review
Escherichia coli Isolated from Migratory Birds
Antibiotic resistance is a global health crisis. Migratory birds are carriers of various types of pathogens including multidrug  Escherichia coli. However, their roles in the dissemination of these resistant pathogens are still being neglected in Bangladesh. MDR E. coli carried by many of these migratory birds could also be positive for APEC-associated virulence genes, which can seriously contribute to the development of human and animal diseases. 
  • 546
  • 23 Dec 2021
Topic Review
Research Trends on Exercise-Induced Muscle Damage
Exercise-induced muscle damage (EIMD) is a phenomenon that occurs following novel or unaccustomed exercise, particularly if the exercise includes a high number of eccentric contractions. The damage process is normally accompanied by a temporary decrease in muscle function (both muscle force and range of motion), increased swelling of the involved muscle group, increased circulation of muscle-specific proteins, and delayed-onset muscle soreness (DOMS). Most of the symptoms and signs of EIMD are present immediately after the initial exercise bout and persist for up to 14 days. 
  • 548
  • 03 Nov 2022
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