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Topic Review
Schistosomiasis in Japan
Schistosomiasis is a water-borne parasitic disease distributed worldwide, and schistosomiasis japonica is prevalent in the People’s Republic of China, the Philippines, and a few regions of Indonesia. Although significant achievements have been obtained in these endemic countries, great challenges still exist to reach the elimination of schistosomiasis japonica, as the occurrence of flooding can lead to several adverse consequences on the prevalence of schistosomiasis.
  • 520
  • 06 Dec 2021
Topic Review
SCD and Genetic Propensity for Dementia beyond Apolipoproteinε4
Subjective cognitive decline (SCD) has been described as a probable early stage of dementia, as it has consistently appeared to precede the onset of objective cognitive impairment. SCD is related to many risk factors, including genetic predisposition for dementia. The Apolipoprotein (APOE) ε4 allele, which has been thoroughly studied, seems to explain genetic risk for SCD only partially.
  • 232
  • 14 Mar 2024
Topic Review
Scalp Cooling
Chemotherapy-induced alopecia (CIA), a side effect with high impact, can be prevented by cooling the scalp during the administration of some cytotoxic drugs. Scalp cooling is a well-known method to try to prevent CIA during the administration of cytotoxic drugs for solid tumors. Using scalp cooling, liquid refrigerant is pumped as coolant through a cooling cap that is placed on the head of the patient. In general, scalp cooling is started 20–45 min prior to, during, and up to 20–150 min after the chemotherapy infusion.
  • 261
  • 20 Aug 2021
Topic Review
SARS-CoV-2 Vaccine Hesitancy
The underlying factors of vaccine hesitancy are complex and context-specific, varying across time and socio-demographic variables. Vaccine hesitancy can also be influenced by other factors such as health inequalities, socioeconomic disadvantages, systemic racism, and level of exposure to misinformation online, with some factors being more dominant in certain countries than others. Therefore, strategies tailored to cultures and socio-psychological factors need to be developed to reduce vaccine hesitancy and aid informed decision-making. 
  • 504
  • 13 Dec 2021
Topic Review
SARS-CoV-2 Spike Protein-Induced Dysfunction of the NRP-1/VEGF-A Complex
Long coronavirus disease-19 (COVID-19) is a newly discovered syndrome characterized by multiple organ manifestations that persist for weeks to months, following the recovery from acute disease. Occasionally, neurological and cardiovascular side effects mimicking long COVID-19 have been reported in recipients of COVID-19 vaccines. Hypothetically, the clinical similarity could be due to a shared pathogenic role of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike (S) protein produced by the virus or used for immunization. The S protein can bind to neuropilin (NRP)-1, which normally functions as a coreceptor for the vascular endothelial growth factor (VEGF)-A. By antagonizing the docking of VEGF-A to NRP-1, the S protein could disrupt physiological pathways involved in angiogenesis and nociception. One consequence could be the increase in unbound forms of VEGF-A that could bind to other receptors. SARS-CoV-2-infected individuals may exhibit increased plasma levels of VEGF-A during both acute illness and convalescence, which could be responsible for diffuse microvascular and neurological damage.
  • 446
  • 20 Jan 2023
Topic Review
SARS-CoV-2 Mutational Pattern in Greece
From the 2500 clinical specimens, 220 were tested positive for SARS-CoV-2 indicating a prevalence of 8.8% among suspected cases. The RT-PCR Ct (Cycle threshold) Value ranged from 19 to 25 which corresponds to medium to high copy numbers of the virus in the positive samples.
  • 400
  • 21 Jan 2022
Topic Review
SARS-CoV-2 Genomics
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a great threat to public health, being a causative pathogen of a deadly coronavirus disease (COVID-19). It has spread to more than 200 countries and infected millions of individuals globally. Although SARS-CoV-2 has structural/genomic similarities with the previously reported SARS-CoV and MERS-CoV, the specific mutations in its genome make it a novel virus. Available therapeutic strategies failed to control this virus. Despite strict standard operating procedures (SOPs), SARS-CoV-2 has spread globally and it is mutating gradually as well.
  • 693
  • 02 Mar 2021
Topic Review
SARS-CoV-2 Detection from Surface Samples
Contaminated surfaces have been discussed as a possible source of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Under experimental conditions, SARS-CoV-2 can remain infectious on surfaces for several days. However, the frequency of SARS-CoV-2 detection on surfaces in healthcare settings and the public is currently not known. A systematic literature review was performed. On surfaces around COVID-19 cases in healthcare settings (42 studies), the SARS-CoV-2 RNA detection rates mostly were between 0% and 27% (Ct values mostly > 30). Detection of infectious SARS-CoV-2 was only successful in one of seven studies in 9.2% of 76 samples. Most of the positive samples were obtained next to a patient with frequent sputum spitting during sampling. Eight studies were found with data from public surfaces and RNA detection rates between 0% and 22.1% (Ct values mostly >30). Detection of infectious virus was not attempted. Similar results were found in samples from surfaces around confirmed COVID-19 cases in non-healthcare settings (7 studies) and from personal protective equipment (10 studies). Therefore, it seems plausible to assume that inanimate surfaces are not a relevant source for transmission of SARS-CoV-2. In public settings, the associated risks of regular surface disinfection probably outweigh the expectable health benefits.
  • 524
  • 06 Aug 2021
Topic Review
SARS-CoV-2 and Brain
The second year of the COVID-19 (coronavirus disease) pandemic has seen the need to identify and assess the long-term consequences of a SARS-CoV-2 infection on an individual’s overall wellbeing, including adequate cognitive functioning. ‘Cognitive COVID’ is an informal term coined to interchangeably refer to acute changes in cognition during COVID-19 and/or cognitive sequelae with various deficits following the infection. These may manifest as altered levels of consciousness, encephalopathy-like symptoms, delirium, and loss of various memory domains. Dysexecutive syndrome is a peculiar manifestation of ‘Cognitive COVID’ as well.
  • 495
  • 12 Aug 2021
Topic Review
Sarcopenic Dysphagia
Sarcopenia, defined as a decline in muscle mass and function related to aging, affects both limb and swallowing-related muscles. Sarcopenic dysphagia is characterized by decreased swallowing function; therefore, early detection of subclinical dysphagia and subsequent intervention appear to be crucial in the elderly. 
  • 578
  • 17 Nov 2021
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