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Topic Review
Talar Fractures
Talar fractures are associated with relatively poor postoperative outcomes, high rates of AVN, and posttraumatic osteoarthritis. Poor outcomes revealed a positive association with fracture severity. Prospective studies investigating predictors for treatment success and/or failure are urgently needed to improve the overall quality of life and function of patients undergoing surgical treatment due to talar fractures.
  • 509
  • 11 Aug 2021
Topic Review
Advanced Glycation End Products
Diabetes mellitus (DM) is considered one of the most massive epidemics of the twenty-first century due to its high mortality rates caused mainly due to its complications; therefore, the early identification of such complications becomes a race against time to establish a prompt diagnosis. The research of complications of DM over the years has allowed the development of numerous alternatives for diagnosis. Among these emerge the quantification of advanced glycation end products (AGEs) given their increased levels due to chronic hyperglycemia, while also being related to the induction of different stress-associated cellular responses and proinflammatory mechanisms involved in the progression of chronic complications of DM. Additionally, the investigation for more valuable and safe techniques has led to developing a newer, noninvasive, and effective tool, termed skin fluorescence (SAF).
  • 1.1K
  • 10 Aug 2021
Topic Review
Healthcare Safety Nets during COVID-19
Healthcare safety net is an important concept during covid-19 infectious diseases. In the case of covid-19, the healthcare safety net meets the safety requirements, improves the quality of life, and reduces the turnover rate and mortality of patients.
  • 398
  • 10 Aug 2021
Topic Review
Prevention of Heat-Related Illnesses
Extreme temperatures are known to have negative consequences on the environment and the ecosystem. Already more frequent and intense heat waves are likely to increase in the future due to a projected 0.1–0.2-degree Celsius rise in temperature by 2100. Extreme heat can lead to a spectrum of health-related conditions that range from mild to severe and include, but are not limited to, heat dehydration, cramps, exhaustion syncope and stroke; these are referred to as heat-related illnesses (HRIs).
  • 433
  • 10 Aug 2021
Topic Review
Drosophila with Super-Resolution Microscopy
In recent decades, fluorescent microscopy has become the most popular tool of cell and developmental biologists, since fluorescent labeling offers high molecular specificity, and due to its low invasiveness, it has become the leading method to study living cells, tissues or organisms. In the early days, only widefield applications were available, but with later technological advances, every aspect of microscopy was improved tremendously, resulting in the development of specialized microscopes, such as optical sectioning confocal microscopes, spinning disk confocal microscopes, light sheets, TIRF and multi-photon microscopic tools. Despite the remarkable progress, all these techniques remained limited by the wavelength of light at around 200-250 nm. A turning point came when scientists found ways to get around this obstacle and developed several nanoscopic methods that are able to increase the resolution up to 2-10 nm, allowing the study and understanding of the cellular structures at the molecular level by broadly applicable microscopic approaches.
  • 428
  • 09 Aug 2021
Topic Review
SARS-CoV-2 Detection from Surface Samples
Contaminated surfaces have been discussed as a possible source of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Under experimental conditions, SARS-CoV-2 can remain infectious on surfaces for several days. However, the frequency of SARS-CoV-2 detection on surfaces in healthcare settings and the public is currently not known. A systematic literature review was performed. On surfaces around COVID-19 cases in healthcare settings (42 studies), the SARS-CoV-2 RNA detection rates mostly were between 0% and 27% (Ct values mostly > 30). Detection of infectious SARS-CoV-2 was only successful in one of seven studies in 9.2% of 76 samples. Most of the positive samples were obtained next to a patient with frequent sputum spitting during sampling. Eight studies were found with data from public surfaces and RNA detection rates between 0% and 22.1% (Ct values mostly >30). Detection of infectious virus was not attempted. Similar results were found in samples from surfaces around confirmed COVID-19 cases in non-healthcare settings (7 studies) and from personal protective equipment (10 studies). Therefore, it seems plausible to assume that inanimate surfaces are not a relevant source for transmission of SARS-CoV-2. In public settings, the associated risks of regular surface disinfection probably outweigh the expectable health benefits.
  • 548
  • 06 Aug 2021
Topic Review
Economic Burden of Stroke Disease
Globally, one of the main causes of non-communicable disease as a cause of death every year is stroke. The objective of this study was to analyze the burden in consequence of stroke. 
  • 489
  • 06 Aug 2021
Topic Review
Artificial Intelligence and COVID-19 Pandemic
The COVID-19 pandemic has worked as a catalyst, pushing governments, private companies, and healthcare facilities to design, develop, and adopt innovative solutions to control it, as is often the case when people are driven by necessity. After 18 months since the first case, it is time to think about the pros and cons of such technologies, including artificial intelligence—which is probably the most complex and misunderstood by non-specialists—in order to get the most out of them, and to suggest future improvements and proper adoption. 
  • 577
  • 05 Aug 2021
Topic Review
Plant Biotechnology based COVID19-vaccines
Many pathogenic viral pandemics have caused threats to global health; the COVID-19 pandemic is the latest. Its transmission is growing exponentially all around the globe, putting constraints on the health system worldwide. A novel coronavirus, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), causes this pandemic. Many candidate vaccines are available at this time for COVID-19, and there is a massive international race underway to procure as many vaccines as possible for each country. However, due to heavy global demand, there are strains in global vaccine production. The use of a plant biotechnology-based expression system for vaccine production also represents one part of this international effort, which is to develop plant-based heterologous expression systems, virus-like particles (VLPs)-vaccines, antiviral drugs, and a rapid supply of antigen-antibodies for detecting kits and plant origin bioactive compounds that boost the immunity and provide tolerance to fight against the virus infection. This review will look at the plant biotechnology platform that can provide the best fight against this global pandemic.
  • 860
  • 04 Aug 2021
Topic Review
Ultra-Processed Food Availability
UPF are described as “processed ingredients typically combined with the sophisticated use of additives to make them edible, palatable and habit forming”.
  • 611
  • 04 Aug 2021
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