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All Topic Review Biography
Topic Review
SCD and Genetic Propensity for Dementia beyond Apolipoproteinε4
Subjective cognitive decline (SCD) has been described as a probable early stage of dementia, as it has consistently appeared to precede the onset of objective cognitive impairment. SCD is related to many risk factors, including genetic predisposition for dementia. The Apolipoprotein (APOE) ε4 allele, which has been thoroughly studied, seems to explain genetic risk for SCD only partially.
  • 354
  • 14 Mar 2024
Topic Review
Detection of Pancreatic Cancer
The pancreas is a vital organ with exocrine and endocrine functions. Pancreatitis is an inflammation of the pancreas caused by alcohol consumption and gallstones. This condition can heighten the risk of pancreatic cancer (PC), a challenging disease with a high mortality rate. Genetic and epigenetic factors contribute significantly to PC development, along with other risk factors. Early detection is crucial for improving PC outcomes. Diagnostic methods, including imagining modalities and tissue biopsy, aid in the detection and analysis of PC. In contrast, liquid biopsy (LB) shows promise in early tumor detection by assessing biomarkers in bodily fluids. Understanding the function of the pancreas, associated diseases, risk factors, and available diagnostic methods is essential for effective management and early PC detection. The current clinical examination of PC is challenging due to its asymptomatic early stages and limitations of highly precise diagnostics. Screening is recommended for high-risk populations and individuals with potential benign tumors. Among various PC screening methods, the N-NOSE plus pancreas test stands out with its high AUC. Compared to other commercial products, the N-NOSE plus pancreas test offers a cost-effective solution for early detection. However, additional diagnostic tests are required for confirmation. Further research, validation, and the development of non-invasive screening methods and standardized scoring systems are crucial to enhance PC detection and improve patient outcomes. This review outlines the context of pancreatic cancer and the challenges for early detection.
  • 354
  • 11 Oct 2023
Topic Review
Hearing Rehabilitation in Vestibular Schwannoma
The most common complaint among patients with vestibular schwannoma (VS) is hearing loss. This significantly affects the quality of life before, during, and after treatment for patients with VS. Untreated hearing loss in VS patients may even lead to depression and feelings of social isolation. A variety of devices are available for hearing rehabilitation for patients with vestibular schwannoma. 
  • 353
  • 30 May 2023
Topic Review
The Prognostic Importance of ctDNA in Rectal Cancer
An individualized treatment approach is necessary to improve survival and quality of life in rectal cancer. Tools to stratify patients are currently missing. Circulating tumor DNA seems to be a good candidate, but results are sparse, conflicting and characterized by lack of a uniform approach. The ctDNA status may be of importance to the long-term prognosis, but the area of research is new and is short of dedicated studies. There is an obvious need for standardization in ctDNA research, and the issue should be addressed in future research. 
  • 353
  • 25 May 2022
Topic Review
COVID and Gender in Asia-Pacific Region
The COVID-19 pandemic has been the largest infectious disease epidemic to affect the human race since the great influenza pandemic of 1918-19 and is close to approaching the number of deaths from the earlier epidemic. The data on COVID-19 shows that the rate of clinical cases is about 10% greater in females than males in Asia. The number of deaths is greater in males than in females. Women are more likely to experience the psychological effects of COVID-19 during and after acute infections.
  • 353
  • 28 Dec 2022
Topic Review
Health Status of Afghan Refugees in Europe
Four decades of civil war, violence, and destabilisation have forced millions of Afghans to flee their homes and to move to other countries worldwide. This increasing phenomenon may challenge physicians unfamiliar with the health status of this population, which may be markedly different from that of the host country. Moreover, several factors during their migration, such as transport in closed containers, accidental injuries, malnutrition, and accommodation in detention centres and refugee camps have a major influence on the health of refugees.
  • 353
  • 08 Mar 2023
Topic Review
Lycium barbarum Deep-Processing Products of Fermentation
Lycium barbarum, a homology of medicine and food, contains many active ingredients including polysaccharides, polyphenol, betaine, and carotenoids, which has health benefits and economic value. The bioactive components in Lycium barbarum exhibit the effects of antioxidation, immune regulation, hypoglycemic effects, and vision improvement.
  • 353
  • 04 Mar 2024
Topic Review
Nursing Interventions Classification and Nurses’ Workloads
The Nursing Interventions Classification allows the systematic organisation of care treatments performed by nurses, and an estimation of the time taken to carry out the intervention is included in its characteristics. The evidence found through the use of Nursing Interventions Classification (NIC) terminology to determine nurses’ workloads is not conclusive. The NIC time averages are an adequate tool for understanding the impact of nurses’ workload on people’s health care. Yet the number of studies needs to be increased to provide more scientific evidence, along with improvements in methodological quality and rigour. Nurses must implement the quantity and quality of the recording in standardised NIC terminology throughout health records and in all clinical settings to advance the study of its relationship to the measurement of nurses’ workload. This could substantially contribute to improvements in staffing and quality of patient care.
  • 352
  • 04 Jul 2022
Topic Review
Human behaviour affected by COVID-19 lockdown
The Coronavirus disease 2019 (COVID-19) is a severe acute respiratory syndrome which is caused by the novel coronavirus SARS-CoV-2. Many governments around the world implemented a ‘lockdown’ strategy to manage and attempt to lower the number of new COVID-19 infections. There was a blanket prohibition on all mass gatherings, regardless of their nature. Numerous other restrictions were also imposed, including but not limited to the closure of public spaces such as restaurants, playgrounds and parks, and shopping centers, as well as an implementation of distance learning, mandatory quarantine for travelers entering the country, and limitations on the number of people that were allowed to go out from each household. 
  • 352
  • 17 Jan 2022
Topic Review
The Devastating Effects of Sleep Deprivation on Memory
Various factors contribute to sleep deprivation (SD) in the modern world, and these include alcohol consumption, shifting work, exposure to excessive light and noise, stress, anxiety, and certain medical conditions. Insomnia, narcolepsy, restless leg syndrome, and obstructive sleep apnea are some of the manifestations of SD. Numerous studies have examined the effects of SD on memory, with the majority showing that sleep disorders negatively affect memory.
  • 352
  • 16 Aug 2023
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