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Topic Review
Dental Implants in People with Osteogenesis Imperfecta
Dental implants have a high survival rate in patients with osteogenesis imperfecta. Therefore, dental implants may be a viable treatment option for replacing missing teeth.
  • 653
  • 07 Feb 2022
Topic Review
Comparison of Road Noise Policies
Developing innovative noise policies that build on international best practices is difficult when policies around the world differ along many dimensions, ranging from different sources covered to different levels of governance involved. This is particularly critical in the context of road traffic, identified as one of the main culprits leading to noise-associated complaints and health issues. 
  • 502
  • 07 Feb 2022
Topic Review
COVID-19 Pandemic on Employee Sleep Quality
COVID-19 was declared a pandemic on 11 March 2020, following a rapid, exponential increase in global cases. The COVID-19 pandemic was associated with depression, anxiety, sleep disturbances, distress, and suicidal ideations. This study explored the association of the COVID-19 pandemic and employee sleep quality at a healthcare technology and services organization.
  • 363
  • 07 Feb 2022
Topic Review
Prehabilitation in Aged Patients Undergoing Cardiothoracic Surgeries
An increasing number of advanced age patients are considered for cardiothoracic surgeries. Prehabilitation optimizes the patients’ functional capacity and physiological reserve. However, the effectiveness of prehabilitation on physical functioning and postoperative recovery in the scope of cardiothoracic surgery is still uncertain.
  • 414
  • 07 Feb 2022
Topic Review
Receptor-Mediated Targeted Delivery of Surface-ModifiedNanomedicine in Breast Cancer
Breast cancer therapeutic intervention continues to be ambiguous owing to the lack of strategies for targeted transport and receptor-mediated uptake of drugs by cancer cells. In addition to this, sporadic tumor microenvironment, prominent restrictions with conventional chemotherapy, and multidrug-resistant mechanisms of breast cancer cells possess a big challenge to even otherwise optimal and efficacious breast cancer treatment strategies. Surface-modified nanomedicines can expedite the cellular uptake and delivery of drug-loaded nanoparticulate constructs through binding with specific receptors overexpressed aberrantly on the tumor cell.
  • 572
  • 07 Feb 2022
Topic Review
Suicidal Ideation Mechanism
Suicidal ideation mechanism is the psychological process of how thoughts of killing oneself emerge and persist in the mind. From the mindsponge-based suicidal ideation mechanism perspective, there are two conditions for suicidal ideation to happen: (1) the existence of accessible suicide-related information in the environment, and (2) the subjective perception that suicide being a beneficial option. Psychosocial factors (e.g. social connectedness or burdensomeness) can affect these two conditions and, in turn, influence the probability of suicidal ideation.
  • 1.5K
  • 04 Feb 2022
Topic Review
Ozone Therapy
ozone therapy can induce an adaptive antioxidant and anti-inflammatory response, which could be potentially useful in the management of chemotherapy-induced peripheral neuropathy. 
  • 417
  • 31 Jan 2022
Topic Review
Livestock-Associated Zoonoses
Human and animal health are intimately connected. This idea has been known for more than a century but now it has gained special importance because of the increasing threat from zoonoses. Zoonosis is defined as any infection naturally transmissible from vertebrate animals to humans. As the frequency and prevalence of zoonotic diseases increase worldwide, they become a real threat to public health. In addition, many of the newly discovered diseases have a zoonotic origin. Due to globalization and urbanization, some of these diseases have already spread all over the world, caused by the international flow of goods, people, and animals. However, special attention should be paid to farm animals since, apart from the direct contact, humans consume their products, such as meat, eggs, and milk. Therefore, zoonoses such as salmonellosis, campylobacteriosis, tuberculosis, swine and avian influenza, Q fever, brucellosis, Shiga-toxic Escherichia coli (STEC) infections, and listeriosis are crucial for both veterinary and human medicine. Consequently, in the suspicion of any zoonoses outbreak, the medical and veterinary services should closely cooperate to protect the public health. 
  • 525
  • 30 Jan 2022
Topic Review
Sleep Medication in Older Adults
Pharmacy students and supervising community pharmacists are well placed to identify problems related to patients’ sleep disorders. Special attention should be given to the patient’s lifestyle.  A discussion with patients about their sleep patterns, nycturia and fluid intake. Another key point concerns the reassessment of hypnotic medications, particularly upon discharge from hospital; medications were rarely reassessed, and the medication use often failed to comply with the summary of product characteristics. Community pharmacists could collaborate with family physicians to facilitate the discontinuation of hypnotic medications and increase the patient’s commitment to change. Greater awareness of the ADRs associated with hypnotics might help to motivate the patients in this respect.
  • 262
  • 30 Jan 2022
Topic Review
Inflammatory Burden and Immunomodulative Therapeutics of Cardiovascular Diseases
Besides traditional risk factors, accumulated evidence suggested that a high inflammatory burden has emerged as a key characteristic modulating both the pathogenesis and progression of cardiovascular diseases, inclusive of atherosclerosis and myocardial infarction. To mechanistically elucidate the correlation, signalling pathways downstream to Toll-like receptors, nucleotide oligomerisation domain-like receptors, interleukins, tumour necrosis factor, and corresponding cytokines were raised as central mechanisms exerting the effect of inflammation. Other remarkable adjuvant factors include oxidative stress and secondary ferroptosis. These molecular discoveries have propelled pharmaceutical advancements. Statin was suggested to confer cardiovascular benefits not only by lowering cholesterol levels but also by attenuating inflammation. Colchicine was repurposed as an immunomodulator co-administered with coronary intervention. Novel interleukin-1β and −6 antagonists exhibited promising cardiac benefits in the recent trials as well. Moreover, manipulation of gut microbiota and associated metabolites was addressed to antagonise inflammation-related cardiovascular pathophysiology. The gut-cardio-renal axis was therein established to explain the mutual interrelationship.
  • 302
  • 29 Jan 2022
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