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All Topic Review Biography
Topic Review
Trauma in Rapes and Assaults
This entry describes that psychological trauma in rapes and assaults is a serious public health issue. 
  • 490
  • 14 Dec 2021
Topic Review
The Tryptophan-Kynurenine Metabolic Pathway
Tryptophan (TRP) is one of the essential amino acids, which participates in protein synthesis. The tryptophan’s main metabolic route is the kynurenine pathway (KP) through which approximately 90-95% of TRP degrades into nicotinamide adenine dinucleotide (NAD+) and other bioactive metabolites. The appropriate amount of NAD+ is essential to maintain the operation and the viability of cells. The other molecules are neurotoxic, neuroprotective, oxidant, antioxidant, and/or immune modifiers. They play an important role in the function of the brain and the peripheral tissues. The change in the levels of the bioactive molecules is considered to contribute to the development of a wide range of illnesses from cancer to immunologic, neurodegenerative, and psychiatric diseases.
  • 10.9K
  • 10 Aug 2021
Topic Review
Higher Blood Pressure & Neurodegeneration
High Blood Pressure (Hypertension) is a major risk factor for cerebral health. Midlife hypertension is associated with a two- to five-fold increased risk of stroke, and up to 50% greater risk of developing vascular dementia. Moreover, hypertension is also linked to the development of amyloid angiopathy, the progression of white matter lesions (WMLs), and neurodegeneration. This recent meta-analysis demonstrates that higher blood pressure, even within the normal range, is associated with a reduction in global and regional brain volumes.
  • 484
  • 06 Mar 2021
Topic Review
Post-Traumatic Stress Disorder and Thalamus
Post-traumatic stress disorder is a common mental disorder, with high lifetime prevalence approximately 6–10% . The prevalence of PTSD in trauma-exposed people has been approximately 20%. PTSD is induced by traumatic stress including life threatening, actual or threatened severe injury, and sexual violence. In DSM-V criteria, PTSD has the following symptoms: intrusion of unwanted memory updates related to traumatic stress, avoidance for reminders, negative alterations in mood, and hyper-arousal. Conservatively, fear-conditioned learning involving the amygdala has been considered one of the causative factors.
  • 1.3K
  • 03 Mar 2021
Topic Review
Psychological First Aid
Psychological First Aid (PFA) focuses on providing humane, supportive, and practical help to individuals who are suffering and in need of support in the immediate aftermath of a disaster [20]. The three main principles of PFA are to look (for safety, for who needs help), listen (to the person in distress) and link (to further support) [20,24].
  • 471
  • 26 Feb 2021
Topic Review
Suicide Behaviors
Suicides and suicidal behaviors are very important causes of mortality and morbidity and have become a serious global problem. More than 800,000 people die from suicide every year. Previous researches have established that lipids play an important role in the pathogenesis of suicide.
  • 350
  • 24 Feb 2021
Topic Review
Chromatin Remodeler CHD8
Chromodomain Helicase DNA-binding 8 (CHD8) is a high confidence risk factor for autism spectrum disorders (ASDs) and the genetic cause of a distinct neurodevelopmental syndrome with the core symptoms of autism, macrocephaly, and facial dysmorphism. The role of CHD8 is well-characterized at the structural, biochemical, and transcriptional level. By contrast, much less is understood regarding how mutations in CHD8 underpin altered brain function and mental disease. Studies on various model organisms have been proven critical to tackle this challenge.
  • 483
  • 12 Feb 2021
Topic Review
Pharmacogenomic Biomarkers in Psychiatry
Pharmacogenomic biomarkers are potential individual genetic variations that can affect drug response influencing both pharmacokinetic parameters by causing variable activity of the systems responsible for the absorption, distribution, metabolism, and excretion of the drug and pharmacodynamic parameters like the mechanisms of action of the drug. Here, the term "pharmacogenomic biomarkers in psychiatry" means those related to a variety of psychiatric disorders, such as depression, ADHD, narcolepsy, schizophrenia, bipolar disorder, and epilepsy. 
  • 657
  • 10 Feb 2021
Topic Review
Death Anxiety
Death anxiety is an unavoidable common phenomenon in our lives across cultures and religions. It is multidimensional and explained by different theoretical frameworks. Death anxiety can have negative impacts on wellbeing. Death is an inevitable experience that generates a reduced sense of safety and stronger fear (Alkozei et al. 2019). 
  • 6.4K
  • 06 Feb 2021
Topic Review
Late Life Depression and Dementia
The number of people living with dementia and Alzheimer’s disease is growing rapidly, making dementia one of the biggest challenges for this century. Many studies have indicated that depression plays an important role in development of dementia, including Alzheimer’s disease; depression, especially, during the late life may either increase the risk of dementia or even being its prodromal stage. Despite a notably large number of carried observational studies and/or clinical trials, the association between the late life depression and dementia remains, due to the complexity of their relationship, still unclear. Moreover, during past two decades multiple other (non-)modifiable risk and possibly protective factors such as the hypertension, social engagement, obesity, level of education or physical (in)activity have been identified and their relationship with the risk for development of dementia and Alzheimer’s disease has been extensively studied. It has been proposedthat to understand mechanisms of dementia and Alzheimer’s disease pathogeneses require their multifactorial nature represented by these multiple factors to be considered. In this work, we summarize the recent literature findings on roles of the late life depression and the other known (non-)modifiable risk and possibly protective factors in development of dementia and Alzheimer’s disease. Then, we provide evidences supporting hypotheses that (i) depressive syndromes in latelife may indicate the prodromal stage of dementia (Alzheimer’s disease) and, (ii) the interplay among the multiple (non-)modifiable risk and protective factors should be considered to gain a better understanding of dementia and Alzheimer’s disease pathogeneses. We also discuss the evidences of recently established interventions considered to prevent or delay the prodromes of dementia and provide the prospective future directions in prevention and treatment of dementia and Alzheimer’s disease using both the single-domain and multidomain interventions.
  • 447
  • 05 Feb 2021
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