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Topic Review
Urolithins
The impact of host–microbiome interactions on cognitive health and disease has received increasing attention. Microbial-derived metabolites produced in the gut are one of crucial mechanisms of the gut–brain axis interaction, showing attractive perspectives. Urolithins (Uros) are gut microbial-derived metabolites of ellagitannins and ellagic acid, whose biotransformation varies considerably between individuals and decreases greatly with age.
  • 112
  • 25 Sep 2023
Topic Review
Replicative Senescence in Different Types of Stem Cells
Stem cells serve as a source of cellular material in embryogenesis and postnatal growth and regeneration. This requires significant proliferative potential ensured by sufficient telomere length. Telomere attrition in the stem cells and their niche cells can result in the exhaustion of the regenerative potential of high-turnover organs, causing or contributing to the onset of age-related diseases. Telomerase activity is present in most types of adult stem cells, though at substantially lower levels. Such lower levels are sufficient for slowing down telomere shortening and expanding the replicative lifespan  but cannot prevent replicative senescence. In this case, low telomerase expression may provide protection against the malignant transformation of stem cells.
  • 766
  • 13 Oct 2022
Topic Review
Primary Gastrointestinal T-Cell Lymphoma and Indolent Lymphoproliferative Disorder
Primary gastrointestinal (GI) T-cell neoplasms are extremely rare heterogeneous disease entities with distinct clinicopathologic features. Given the different prognoses of various disease subtypes, clinicians and pathologists must be aware of the key characteristics of these neoplasms, despite their rarity.
  • 350
  • 06 Dec 2021
Topic Review
Polyamines in Neurodegenerative Diseases
Polyamines (Pas) are short molecules that exhibit two or three amine groups that are positively charged at a physiological pH. These small molecules are present in high concentrations in a wide variety of organisms and tissues, suggesting that they play an important role in cellular physiology. Polyamines include spermine, spermidine, and putrescine, which play important roles in age-related diseases that have not been completely elucidated. Aging is a natural process, defined as the time-related deterioration of the physiological functions; it is considered a risk factor for degenerative diseases such as cardiovascular, neurodegenerative, and musculoskeletal diseases; arthritis; and even cancer.
  • 304
  • 27 Nov 2023
Topic Review Peer Reviewed
Oxidative Stress in Relation to Aging and Exercise
Oxidative stress is an imbalance between oxidants and antioxidants in favor of the oxidants, resulting in disruption of redox signaling and control and causing molecular damage. Oxidative stress is related to a variety of diseases, for example, cardiovascular diseases, neurodegenerative diseases, infections, and cancer. It might be that oxidative stress, and, more specifically, reactive oxygen species (ROS), affects longevity in a subtle way through signaling. Possible therapies to reduce oxidative stress in the elderly are nutritional intervention (for example, caloric restriction (CR)) and exercise. Exercise is associated with favorable changes in the expression of antioxidant enzymes and the oxidative stress status in general. A diet with CR also seems to be a promising way to reduce oxidative stress by decreasing oxidant emission and improving antioxidant mechanisms. A better understanding of where the antioxidant mechanisms in the elderly fail could be a big step forward in developing new therapies (such as exercise or diet) that prevent oxidative damage and cellular dysfunction with age.
  • 305
  • 25 Aug 2022
Topic Review
Nicotinamide Adenine Dinucleotide Homeostasis
Nicotinamide adenine dinucleotide (NAD+) is one of the primary coenzymes in metabolic processes and is involved with numerous other pathways, such as energy expenditure, metabolic and stress adaptations, and circadian rhythm maintenance. NAD+ levels sharply decline with age, and this decline can be attributed to the activity of CD38, an enzyme responsible for the degradation of NAD+, which disrupts the NAD+ synthesis pathways during the course of aging. 
  • 372
  • 16 Feb 2023
Topic Review
Muscle Delivery of Mitochondria-Targeted Drugs for Sarcopenia
An impairment in mitochondrial homeostasis plays a crucial role in the process of aging and contributes to the incidence of age-related diseases, including sarcopenia, which is defined as an age-dependent loss of muscle mass and strength. Mitochondrial dysfunction exerts a negative impact on several cellular activities, including bioenergetics, metabolism, and apoptosis. In sarcopenia, mitochondria homeostasis is disrupted because of reduced oxidative phosphorylation and ATP generation, the enhanced production of reactive species, and impaired antioxidant defense.
  • 482
  • 05 Dec 2022
Topic Review
Multidimensional Roles of GRK5 in Molecular Aging
Considerable evidence now suggests that GRK5 can act as a molecular 'bridging' factor, allowing signaling regulation in pathophysiological settings that can control the connectivity between both the cardiovascular and neurophysiological complications of aging. 
  • 667
  • 23 Oct 2022
Topic Review
Mediterranean Diet and Physical Activity for Successful Aging
Physical activity among older adults has multiple benefits but is first essential to determine the recommended activity. Physical activity may reduce inflammation and oxidative stress through multiple mechanisms, including the reduced formation of ROS and the accelerated production of DNA-repairing enzymes and antioxidant proteins; furthermore, it can moderate oxidative stress by decreasing TNF-α, C-reactive protein, and interleukin-6. There is conflicting evidence on the effect of physical activity and hormone levels, depending on the kind and length of activity, which can increase the levels of dehydroepiandrosterone and testosterone, but there is no clear evidence.
  • 553
  • 25 Oct 2021
Topic Review
Income Disparity between Agricultural and Non-Agricultural Households
The income disparity between agricultural and non-agricultural households has been increasing in many countries. Studies in the labor economics literature often link population aging and underemployment to low labor participation and productivity, fewer savings, and greater financial pressure on households. 
  • 561
  • 17 Dec 2021
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