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Topic Review
Anti-Caries Nanomaterials
Caries is the most common and extensive oral chronic disease. Due to the lack of anti-caries properties, traditional caries filling materials can easily cause secondary caries and lead to treatment failure. Nanomaterials can interfere with the bacteria metabolism, inhibit the formation of biofilm, reduce demineralization, and promote remineralization, which is expected to be an effective strategy for caries management. 
  • 630
  • 14 Jan 2021
Topic Review
Antibacterial Agents for Concrete
Concrete is the most used material for the construction of millions of structures around the world. Cementitious structures are often exposed to high humidity environments and the attack of atmospheric agents, such as acid rain, which make them vulnerable to microbial attachment with consequent colonization and deterioration over time. In the light of these considerations, the researchers turned their attention to designing green and sustainable alternative materials that exhibit similar characteristics to the traditional concrete by using nanotechnologies.
  • 893
  • 10 Jan 2022
Topic Review
Antibiotics-Coated Gold Nanoparticles to Combat Antimicrobial Resistance
Antimicrobial resistance (AMR) has become an alarming threat to the successful treatment of rapidly growing bacterial infections because of the abuse and misuse of antibiotics. Traditional antibiotics bear many limitations including restricted bioavailability, inadequate penetration and the emergence of antimicrobial-resistant microorganisms. Recent advances in nanotechnology for the introduction of nanoparticles with fascinating physicochemical characteristics have been predicted as an innovative means of defence against antimicrobial-resistant diseases. The use of nanoparticles renders several benefits including improved tissue targeting, better solubility, improved stability, enhanced epithelial permeability and minimal side effects.
  • 1.9K
  • 07 Feb 2024
Topic Review
Anticancer Targeted Drug Delivery Nanotechnology
The construction of nanosized drug delivery systems possesses tremendous potential due to their ability to improve the solubility of poorly soluble drugs and to reduce metabolism by dissolving them in their hydrophobic or hydrophilic compartment. In addition, nanomedicine holds the advantages of passive targeting ability due to an enhanced permeability and retention (EPR) effect, a large surface-to-volume ratio for drug loading, a tunable size for modification, a prolonged plasma half-life and a different biodistribution profile compared to conventional chemotherapy. Typical nano-based delivery vehicles include liposome, micelle, dendrimer, inorganic vector, nanogel and nanoemulsion, while novel nanocarriers also contain biomimetic reconstituted high-density lipoprotein (rHDL), exosome and the hybrid nanoparticle, which come from the mixture of nanomaterials. Each of these nanotools displays its unique physiochemical properties and possesses the ability for further modification of active targeting ligands.
  • 748
  • 11 Aug 2021
Topic Review
Antimicrobial Nanomaterials
Incorporating antimicrobial nanocompounds into materials to prevent microbial adhesion or kill microorganisms has become an increasingly challenging strategy. Many studies have been conducted on the preparation of nanomaterials with antimicrobial properties against diseases caused by pathogens. 
  • 233
  • 01 Sep 2023
Topic Review
Antimicrobial Nanomaterials Based on Halloysite Clay Mineral
Bacterial infections represent one of the major causes of mortality worldwide. Over the years, several nanomaterials with antibacterial properties have been developed. In this context, clay minerals, because of their intrinsic properties, have been efficiently used as antimicrobial agents since ancient times. Halloysite nanotubes are one of the emerging nanomaterials that have found application as antimicrobial agents in several fields. 
  • 372
  • 08 Jan 2023
Topic Review
Antimicrobial Polymer−Based Assemblies
An antimicrobial supramolecular assembly (ASA) is conspicuous in biomedical applications. Among the alternatives to overcome microbial resistance to antibiotics and drugs, ASAs, including antimicrobial peptides (AMPs) and polymers (APs), provide formulations with optimal antimicrobial activity and acceptable toxicity. 
  • 525
  • 26 Jul 2021
Topic Review
AOP Framework
This review outlines the current status and next steps for the development and use of the AOP framework in decision making regarding the safety of MNs. Opportunities and challenges toward the advancement and adoption of AOPs as part of an integrated approach to testing and assessment (IATA) of MNs are identified and specific actions proposed to advance the development, use and acceptance of the AOP framework and associated testing strategies for MN risk assessment and decision making. The intent of this review is to reflect the views of a diversity of stakeholders including experts, researchers, policymakers, regulators, risk assessors and industry representatives on the current status, needs and requirements to facilitate future use of AOPs in MN risk assessment. It incorporates the views and feedback of experts that participated in two workshops hosted as part of an Organization for Economic Cooperation and Development (OECD) Working Party on Manufactured Nanomaterials (WPMN) project titled, “Advancing AOP Development for Nanomaterial Risk Assessment and Categorization” as well as the position of several EU-funded nanosafety research consortia.
  • 1.4K
  • 09 Jul 2020
Topic Review
Application Fields of Silver Nanoparticles
New antiviral drugs and new preventive antiviral strategies are a target of intense scientific interest. Thanks to their peculiar properties, nanomaterials play an important role in this field, and, in particular, among metallic materials, silver nanoparticles were demonstrated to be effective against a wide range of viruses, in addition to having a strong antibacterial effect. Although the mechanism of antiviral action is not completely clarified, silver nanoparticles can directly act on viruses, and on their first steps of interaction with the host cell, depending on several factors, such as size, shape, functionalization and concentration. 
  • 695
  • 24 Mar 2023
Topic Review
Application in Wound Healing
Wound healing requires careful, directed, and effective therapies to prevent infections and accelerate tissue regeneration. In light of these demands, active biomolecules with antibacterial properties and/or healing capacities have been functionalized onto nanostructured polymeric dressings and their synergistic effect examined. In this work, various antibiotics, nanoparticles, and natural extract-derived products that were used in association with electrospun nanocomposites containing cellulose, cellulose acetate and different types of nanocellulose (cellulose nanocrystals, cellulose nanofibrils, and bacterial cellulose) have been reviewed. The impact of these combinations in wound healing are here examined and explored.
  • 705
  • 29 Oct 2020
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