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Topic Review
Trisomy 21 Evaluation
Trisomy 21 (T21), also known as Down syndrome, is one of the most frequently occurring chromosomal aberrations, appearing in 1 in 319 to 1 in 1000 live births. The most frequently diagnosed duplication of chromosome 21 as a result of the abnormal nondisjunction of chromosomes occurs in an estimated 95% of cases, and the remaining 5% are associated with translocation and somatic mosaicism. T21 patients struggle with physical and mental disabilities and many others comorbidities, such as heart defects, thyroid disease, leukemia, cancers, Alzheimer’s disease, and others.
  • 383
  • 16 Jan 2023
Topic Review
Trisomy 18
Trisomy 18, also called Edwards syndrome, is a chromosomal condition associated with abnormalities in many parts of the body.
  • 460
  • 23 Dec 2020
Topic Review
Trisomy 13
Trisomy 13, also called Patau syndrome, is a chromosomal condition associated with severe intellectual disability and physical abnormalities in many parts of the body.
  • 509
  • 23 Dec 2020
Topic Review
Triploid Fish
Over the past decades, evidence is emerging that triploid fish exhibit interesting genetic, anatomical, cellular and biochemical peculiarities with potential growth advantages for the Aquaculture industry are including economic gains and improved feed conversion rate. A review of the current literature indicates that an assessment of the possible advantages and disadvantages of farming triploid sea bass should include the effects of ploidy on flesh quality parameters and in the capacity for aerobic and anaerobic metabolism at different seasonal temperatures. 
  • 1.0K
  • 05 Nov 2020
Topic Review
Triple A Syndrome
Triple A syndrome is an inherited condition characterized by three specific features: achalasia, Addison disease, and alacrima.
  • 483
  • 23 Dec 2020
Topic Review
Tripartite Motif Family
The tripartite motif (TRIM) family comprises at least 80 members in humans, with most having ubiquitin or SUMO E3 ligase activity conferred by their N-terminal RING domain. TRIMs regulate a wide range of processes in ubiquitination- or sumoylation-dependent manners in most cases, and fewer as adaptors. Their roles in the regulation of viral infections, autophagy, cell cycle progression, DNA damage and other stress responses, and carcinogenesis are being increasingly appreciated, and their E3 ligase activities are attractive targets for developing specific immunotherapeutic strategies for immune diseases and cancers.
  • 833
  • 22 Sep 2021
Topic Review
TRIP13 Gene
Thyroid hormone receptor interactor 13: The TRIP13 gene provides instructions for making a protein that has several roles in cell division.
  • 542
  • 25 Dec 2020
Topic Review
TRIP11 Gene
Thyroid hormone receptor interactor 11: The TRIP11 gene provides instructions for making a protein known as Golgi microtubule-associated protein 210 (GMAP-210). 
  • 529
  • 25 Dec 2020
Topic Review
Triosephosphate Isomerase Deficiency
Triosephosphate isomerase deficiency is a disorder characterized by a shortage of red blood cells (anemia), movement problems, increased susceptibility to infection, and muscle weakness that can affect breathing and heart function.  
  • 455
  • 23 Dec 2020
Topic Review
Trimethylornithine Membrane Lipids
Trimethylornithine membrane lipids (TMOs) are a class of intact polar membrane lipids that were discovered in northern wetland Planctomycete species. The structure of TMOs is similar to ornithine lipids, but the terminal nitrogen of the ornithine amino acid head group is trimethylated, which gives the lipid a charged polar head group.
  • 557
  • 29 Jan 2021
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