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Topic Review
Sustainable Agriculture
In the last few decades, a great deal has been written on the use of sustainable agriculture to improve the resilience of ecosystem services to climate change. However, no tangible and systematic evidence exists on how this agriculture would participate in alleviating impacts on vulnerable rural communities. This entry provides a narrative systematic review (SR) integrated with a bibliometric analysis and a concept network analysis to determine how, in this changing climate, sustainable agriculture can increase the resilience of agrosystems. Our search ranged from the date of the first relevant article until the end of 2018.
  • 969
  • 29 Oct 2020
Topic Review
Plant-Endophyte Interaction
Plants interact with diverse microbial communities and share complex relationships with each other. The intimate association between microbes and their host mutually benefit each other and provide stability against various biotic and abiotic stresses to plants. Endophytes are heterogeneous groups of microbes that live inside the host tissue without showing any apparent sign of infection.
  • 970
  • 06 Sep 2022
Topic Review
Triploid Fish
Over the past decades, evidence is emerging that triploid fish exhibit interesting genetic, anatomical, cellular and biochemical peculiarities with potential growth advantages for the Aquaculture industry are including economic gains and improved feed conversion rate. A review of the current literature indicates that an assessment of the possible advantages and disadvantages of farming triploid sea bass should include the effects of ploidy on flesh quality parameters and in the capacity for aerobic and anaerobic metabolism at different seasonal temperatures. 
  • 969
  • 05 Nov 2020
Topic Review
Genetic Variants of SARS-CoV-2 Responsible for Severe COVID-19
The coronavirus disease 2019 (COVID-19) pandemic is a global pandemic caused by severe acute coronavirus 2 syndrome (SARS-CoV-2). Although “COVID-19 is now an established and ongoing health issue which no longer constitutes a public health emergency of international concern”, according to the WHO International Health Regulations Emergency Committee, it continues to have major health, economic, and social consequences worldwide.
  • 971
  • 07 Aug 2023
Topic Review
Rippling Muscle Disease
Rippling muscle disease is a condition in which the muscles are unusually sensitive to movement or pressure (irritable).
  • 969
  • 24 Dec 2020
Topic Review
Structure and Physicochemical Properties of Konjac Glucomannan
Konjac glucomannan (KGM), can not only be applied as a food additive, which greatly improves the taste and flavor of food and extends the shelf life of food but also occupies an important role in T2DM (Type 2 Diabetes Mellitus). KGM can extend gastric emptying time, increase satiety, and promote liver glycogen synthesis, and also has the potential to improve intestinal flora and the metabolic system through a variety of molecular pathways in order to positively regulate oxidative stress and immune inflammation, and protect the liver and kidneys.
  • 969
  • 01 Feb 2023
Topic Review
Spinal Muscular Atrophy
Spinal muscular atrophy (SMA) is a congenital neuromuscular disorder characterized by motor neuron loss, resulting in progressive weakness. SMA is notable in the health care community because it accounts for the most common cause of infant death resulting from a genetic defect. SMA is caused by low levels of the survival motor neuron protein (SMN) resulting from SMN1 gene mutations or deletions. However, patients always harbor various copies of SMN2, an almost identical but functionally deficient copy of the gene. A genotype–phenotype correlation suggests that SMN2 is a potent disease modifier for SMA, which also represents the primary target for potential therapies. Increasing comprehension of SMA pathophysiology, including the characterization of SMN1 and SMN2 genes and SMN protein functions, has led to the development of multiple therapeutic approaches. Until the end of 2016, no cure was available for SMA, and management consisted of supportive measures. Two breakthrough SMN-targeted treatments, either using antisense oligonucleotides (ASOs) or virus-mediated gene therapy, have recently been approved. These two novel therapeutics have a common objective: to increase the production of SMN protein in MNs and thereby improve motor function and survival. However, neither therapy currently provides a complete cure. Treating patients with SMA brings new responsibilities and unique dilemmas. As SMA is such a devastating disease, it is reasonable to assume that a unique therapeutic solution may not be sufficient. Current approaches under clinical investigation differ in administration routes, frequency of dosing, intrathecal versus systemic delivery, and mechanisms of action. Besides, emerging clinical trials evaluating the efficacy of either SMN-dependent or SMN-independent approaches are ongoing.
  • 969
  • 30 Oct 2020
Topic Review
Digital Agriculture Food and Wine
Digital Agriculture, Food, and Wine deals with the implementation and integration of digital data, sensors, technology, and tools on agricultural applications from the farm to consumers. These technologies can range from big data, sensor technology, sensor networks, remote sensing, robotics, unmanned aerial vehicles (UAV). Data processing is performed using new and emerging technologies, such as computer vision, machine learning, and artificial intelligence, among others. The latest advances made by the Digital Agriculture Food and Wine Sciences group (DAFW) from The University of Melbourne deals with crop monitoring/decision making, assessment of quality of produces, non-invasive sensory analysis for consumer perception assessment, and animal stress and welfare assessments.
  • 971
  • 18 Feb 2021
Biography
Sheldon Lee Glashow
Sheldon Lee Glashow (US: /ˈɡlæʃoʊ/,[1][2] UK: /ˈɡlæʃaʊ/;[3] born December 5, 1932) is a Nobel Prize-winning United States theoretical physicist. He is the Metcalf Professor of Mathematics and Physics at Boston University and Eugene Higgins Professor of Physics, Emeritus, at Harvard University, and is a member of the Board of Sponsors for the Bulletin of the Atomic Scientists. Sheldo
  • 968
  • 24 Nov 2022
Topic Review
Neutrophil Extracellular Traps and Human Disease
The first description of a new form of neutrophil cell death distinct from that of apoptosis or necrosis was discovered in 2004 and coined neutrophil extracellular traps “(NETs)” or “NETosis”. Different stimuli for NET formation, and pathways that drive neutrophils to commit to NETosis have been elucidated in the years that followed. Critical enzymes required for NET formation have been discovered and targeted therapeutically. It has become clear that although this mechanism is thought to enhance host defense by ensnaring bacteria within large webs of DNA to increase bactericidal killing capacity, it is also injurious to innocent bystander tissue. Proteases and enzymes released from NETs injure epithelial and endothelial cells, perpetuating inflammation. In the context of autoimmunity, NETs release over 70 well-known autoantigens. NETs are associated with pathology in multiple diseases: lung diseases, vasculitis, autoimmune kidney diseases, atherosclerosis, rheumatoid arthritis, cancer, and psoriasis. Defining these pathways that drive NET release will provide insight into mechanisms of pathological insult and provide potential therapeutic targets.
  • 967
  • 25 Apr 2022
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