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Topic Review
Prevalence and Features of Oral Lesions in COVID-19
Regardless of rapidly emerging findings on oral lesions described in adult SARS-CoV-2-positive subjects, the evidence level remains quite low and rather contrasting. It is well known that multiple viral pathogens, first of all, Herpes and human Papilloma viruses, are directly responsible for the genesis of benign, potentially malignant and malignant lesions of the oral mucosa, underlining the necessity to examine the potential causative role of SARS-CoV-2 in oral lesions. 
  • 425
  • 27 Jun 2022
Topic Review
Barrier Membranes for Guided Bone Regeneration
Guided bone regeneration (GBR) has become a clinically standard modality for the treatment of localized jawbone defects. Barrier membranes play an important role in this process by preventing soft tissue invasion outgoing from the mucosa and creating an underlying space to support bone growth. Different membrane types provide different biological mechanisms due to their different origins, preparation methods and structures. Among them, collagen membranes have attracted great interest due to their excellent biological properties and desired bone regeneration results to non-absorbable membranes even without a second surgery for removal.
  • 422
  • 07 Dec 2022
Topic Review
Local and Systemic Effects of Porphyromonas gingivalis Infection
Porphyromonas gingivalis, a gram-negative anaerobe, is a leading etiological agent in periodontitis. This infectious pathogen can induce a dysbiotic, proinflammatory state within the oral cavity by disrupting commensal interactions between the host and oral microbiota. It is advantageous for P. gingivalis to avoid complete host immunosuppression, as inflammation-induced tissue damage provides essential nutrients necessary for robust bacterial proliferation. When it gains access to circulation, P. gingivalis is able to infect a variety of cells, further triggering a variety of inflammatory and hemostatic responses. Among these is the activation of platelets and neutrophils. Neutrophil responses to P. gingivalis, particularly in the presence of activated platelets, include the release of strongly thrombogenic extracellular DNA traps (NETs). Consequently, this pathogen has the capacity not only to promote localized tissue destructiion of the gums but may also trigger some thromboinflammatory processes.
  • 419
  • 24 Mar 2023
Topic Review
Effects of Wearing Bite-Aligning Mouthguards
The purpose of the present entry was to determine the acute effects of wearing bite-aligning mouthguards on muscle strength, power, agility and quickness in athletes. A search of the current literature was performed using the electronic databases (until 1 May 2021) Web of Science, Scopus and Medline. The inclusion criteria were: (1) descriptive design studies; (2) with randomized clinical trials; (3) examining the within-subject acute effects of wearing mouthguards on functional and neuromuscular performance parameters; (4) in physical active, recreational or highstandard athletes. Twenty-seven studies met the inclusion criteria. Sixteen reported positive effects in some of the variables assessed, two reported negative effects and the rest found no significant differences. Overall, the main findings described in the literature are inconclusive concerning the neuromuscular advantages of using mouthguards in muscle strength, power, agility and quickness. These discrepancies might be related to several factors such as differences in testing protocols, poor control of the jaw magnitude and improper mouthguard designs. Despite these differences, after conducting the present systematic review, the authors speculate that jaw clenching while wearing custom-made, bite-aligning oral devices might promote beneficial effects in lower limb power actions, especially in jump ability and knee extension movements. Thus, athletes might consider the use of mouthguards, not only for their protective role but also for the potential ergogenic effects in specific actions, mainly those for which lower limb muscular power are required.
  • 418
  • 21 Jul 2021
Topic Review
Oral Health Status in Inflammatory Bowel Diseases Patients
Inflammatory bowel diseases (IBD) are chronic disorders that affect the gastrointestinal tract, including the oral cavity. Both Crohn’s disease (CD) and ulcerative colitis (UC) patients have an increased odds of periodontitis coincidence compared to the controls. Moreover, in most studies, patients with IBD are characterized by higher values of caries indices. In conclusion, the risk of oral diseases in IBD patients cannot be clearly established due to the possible association of other factors, e.g., sociodemographic or environmental factors.
  • 417
  • 24 Nov 2021
Topic Review
Diode Lasers for Impacted Teeth Minimally-Invasive Exposure
The use of diode lasers for oral surgery soft tissue procedures is associated with less pain and bleeding, quick recovery, and better surgical site visibility.  For uncovering superficially impacted teeth with no overlying bone layer, the conventional surgical exposure and orthodontic traction often involve reflecting the surgical flap with a scalpel, releasing incisions apical to the adjacent teeth, and managing surgical site bleeding, pain, and postoperative swelling. The management of impacted teeth is time-consuming (two to three years) and expensive.
  • 416
  • 09 May 2022
Topic Review
Oral Microbiota in Patients with Peri-Implant Disease
Peri-implant infections are the most common complications related to the placement of dental implants. There are many microbial similarities between peri-implantitis and periodontitis but due to current laboratory techniques there are just as many differences. The peri-implant microbiota presents a lower microbial quality than the periodontal microbiota, becoming increasingly complex as it progresses from peri-implant mucositis to peri-implantitis. The microbial difference detected between the peri-implant and periodontal microbiota is primarily related to whole bacterial populations, rather than specific bacterial taxa. The use of probiotics could support the reduction of peri-implant pockets, in association with mechanical debridement, due to their mechanism of action of competitive inhibition for adhesion sites. The peri-implant microbiota represents a qualitatively inferior but quantitatively superior bacterial ecosystem for some bacterial genera compared to the periodontal microbiota, showing that a progression from healthy state to peri-implantitis causes changes in microbiota composition in the absence of specific disease-causing bacteria.
  • 412
  • 28 Mar 2022
Topic Review
Periodontitis in Systemic Sclerosis
Systemic sclerosis (SSc) is a chronic, autoimmune, multisystemic disease characterized by aberrant extracellular matrix protein deposition and extreme progressive microvasculopathy. These processes lead to damage within the skin, lungs, or gastrointestinal tract, but also to facial changes with physiognomic and functional alterations, and dental and periodontal lesions. Orofacial manifestations are common in SSc but are frequently overshadowed by systemic complications. In clinical practice, oral manifestations of SSc are suboptimally addressed, while their management is not included in the general treatment recommendations. Periodontitis is associated with autoimmune-mediated systemic diseases, including systemic sclerosis. In periodontitis, the microbial subgingival biofilm induces host-mediated inflammation with subsequent tissue damage, periodontal attachment, and bone loss. When these diseases coexist, patients experience additive damage, increasing malnutrition, and morbidity. 
  • 412
  • 09 Mar 2023
Topic Review
3D Printing in Prosthetic Dentistry
The speed of progress in the evolution of digital dental manufacturing has become truly remarkable. Subtractive methods have achieved remarkable levels of both efficiency and precision in achieving accurate fits, while additive techniques such as 3D printing are gaining prominence at an escalating rate.
  • 411
  • 18 Jun 2024
Topic Review
Novel Antibacterial Approaches for Eradicating Dental Biofilm
Periodontitis is a multifactorial chronic inflammatory disease that affects tooth-supporting soft/hard tissues of the dentition. The dental plaque biofilm is considered as a primary etiological factor in susceptible patients; however, other factors contribute to progression, such as diabetes and smoking. Current management utilizes mechanical biofilm removal as the gold standard of treatment. Antibacterial agents might be indicated in certain conditions as an adjunct to this mechanical approach. Studies suggest efficacy in the use of adjunctive antimicrobials in patients with grade C periodontitis of young age or where the associated risk factors are inconsistent with the amount of bone loss present. Meanwhile, alternative approaches such as photodynamic therapy and probiotics showed limited supportive evidence, and more studies are warranted to validate their efficiency.
  • 406
  • 20 Jan 2022
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