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Topic Review
Sterol Regulatory Element-binding Proteins
Sterol regulatory element-binding protein-1c (SREBP-1c) is a key modulatory molecule involved in lipid homeostasis in the central nervous system. However, little is known about the biological effects of SREBP-1c in the brain. Our previous study uncovered that mice deficient in SREBP-1c exhibit schizophrenia-like behaviors. We analyzed the transcriptomes of the hippocampus of SREBP-1c knockout (KO) mice and wild-type mice in order to investigate whether there are novel molecular mechanisms involved in the neurological aberrations caused by SREBP-1c deficiency. This study found seven differentially expressed genes (three up-regulated and four down-regulated genes) in the hippocampus of SREBP-1c KO mice. For further verification, we selected the three most significantly changed genes: glucagon-like peptide 2 receptors (GLP2R) involved in hippocampal neurogenesis and neuroplasticity as well as in cognitive impairments; necdin (NDN) which is related to neuronal death and neurodevelopmental disorders; and Erb-B2 receptor tyrosine kinase 4 (ERBB4) which is a receptor for schizophrenia-linked protein, neuregulin-1. The protein levels of GLP2R and NDN were considerably decreased, but the level of ERBB4 was significantly increased in the hippocampus of SREBP-1c KO mice. We suggest that these data provide novel molecular evidence for the modulatory role of SREBP-1c in the mouse hippocampus.
  • 1.0K
  • 03 Nov 2020
Topic Review
Deep and Meaningful E-Learning
Deep and meaningful e-learning should be an essential outcome of quality education.
  • 1.0K
  • 25 Mar 2021
Topic Review
Social Innovation in Rural Areas
Social innovation is gaining momentum in academia, policy and practice, as a process by which local communities generate new social relations and become more capable of addressing social needs and opportunities. This entry describes the most essential facts of social innovation processes in rural communities. 
  • 1.0K
  • 17 Jun 2022
Topic Review
Hydraulic Empire
A hydraulic empire (also known as a hydraulic despotism, or water monopoly empire) is a social or government structure which maintains power and control through exclusive control over access to water. It arises through the need for flood control and irrigation, which requires central coordination and a specialized bureaucracy. Often associated with these terms and concepts is the notion of a water dynasty. This body is a political structure which is commonly characterized by a system of hierarchy and control often based on class or caste. Power, both over resources (food, water, energy) and a means of enforcement such as the military, is vital for the maintenance of control.
  • 1.0K
  • 10 Oct 2022
Topic Review
Chinese Herbal Medicine for Depression
Depression is a mood disorder that causes a loss of interest and constant sadness. Central nervous system (CNS)-targeted medications alone are insufficient for the treatment of depression. Multidrug and multitarget Chinese Herbal Medicine (CHM) has great potential to assist in the development of novel medications for the systematic and effective pharmacotherapy of depression.
  • 1.0K
  • 02 Feb 2021
Topic Review
Chinese Emperors Family Tree (Middle)
The following is a family tree of China emperors (420-1279), from the Northern and Southern dynasties period, of first half of the fifth century AD, until the conquest of China by the Mongols under Kublai Khan, and the end of the Southern Song dynasty in 1279. Chinese emperors family tree (ancient) → Chinese emperors family tree (early) → Chinese emperors family tree (middle) → Chinese emperors family tree (late)
  • 1.0K
  • 01 Nov 2022
Topic Review
LBRY
LBRY (/ˈlaɪbrɛri/), is a blockchain-based file-sharing and payment network that powers decentralized platforms, primarily social networks and video platforms. LBRY's creators also created Odysee, an open-source video-sharing website that uses the network, and that was split into a separate company on October 1, 2021. Video platforms built on LBRY, such as Odysee, have been described as decentralized alternatives to YouTube. The company has described Odysee and other platforms it has built utilizing its LBRY protocol as platforms for free speech and lightly moderates content, including removing pornography or the promotion of violence and terrorism.
  • 1.0K
  • 07 Nov 2022
Topic Review
Bebo
Bebo was a social networking website launched in 2005, that now describes itself as "a company that dreams up ideas for fun social apps;" Grant Denholm, the man behind the Bebo relaunch, has confirmed that the site will not be returning as a social network but as a company that makes social apps. The company launched the app Blab in early 2014; it closed in 2016. In December 2014 a new version of Bebo launched as an avatar hashtag messaging app. As of July 2013, it is owned and operated by its founders Michael Birch and Xochi Birch, who took over from Criterion Capital Partners after the company declared bankruptcy.
  • 1.0K
  • 02 Nov 2022
Topic Review
Sawndip
Zhuang characters or Sawndip ([θaɯ˨˦ɗip˥]), are logograms derived from Chinese characters and used by the Zhuang people of Guangxi and Yunnan, China to write the Zhuang languages for more than one thousand years. The script is not only used by the Zhuang but also by the closely related Bouyei in Guizhou, China and Tay in Vietnam and Nùng, in Yunnan, China and Vietnam. Sawndip (Sawndip: 𭨡𮄫)[lower-alpha 1] is a Zhuang word that means "immature characters". The Zhuang word for Chinese characters used in the Chinese language is sawgun (Sawndip: 𭨡倱; "characters of the Han"); gun is the Zhuang term for the Han Chinese. Even now, in traditional and less formal domains, Sawndip is more often used than alphabetical scripts.
  • 1.0K
  • 17 Nov 2022
Topic Review
Live Streaming and Consumer Purchase Intentions
As a new business model, live-streaming commerce has great commercial value. Interactivity, visualization, entertainment, and professionalization play considerable roles in consumer behavioral responses and that their psychological mechanisms are different. Male respondents are more satisfied with interactivity than females. E-commerce platforms are more interactive, visible and professional than social media platforms, and the trust mechanism of social media platforms is immature.
  • 1.0K
  • 28 Jan 2022
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