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Topic Review
Molecular Techniques for Schistosomiasis
Diagnostic tools play a pivotal role in warfare against schistosomiasis but must adapt to the endemic status and objectives of activities. With the decrease of prevalence and infection intensity of schistosomiasis in human beings and livestock, optimal methodologies with high sensitivity and absolute specificity are needed for the detection of asymptomatic cases or light infections, as well as disease surveillance to verify elimination. In comparison with the parasitological methods with relatively low sensitivity and serological techniques lacking specificity, which both had been widely used in previous control stages, the molecular detection methods based on the amplification of promising genes of the schistosome genome may pick up the baton to assist the eventual aim of elimination.
  • 598
  • 29 Mar 2022
Topic Review
Virtual Exercise and Training
The global internet (Internet of Things, IoT) and innovative information and communication technologies (IT/ICT) are already ubiquitous in the social and individual lives of people. Among them, a very significant role is played by Extended Reality (XR) and its classic components such as Virtual (VR), Augmented (AR) and Mixed (MR) Reality. There are many indications that these modern technologies (XR, i.e., VR/AR/MR, and 3D printing/scanning, holography, artificial intelligence and machine learning, robotics or online (VR) tele-medicine) will be the basis and determinants of the organization and functioning of contemporary and future generations.
  • 596
  • 12 Apr 2023
Topic Review
Livestock-Associated Zoonoses
Human and animal health are intimately connected. This idea has been known for more than a century but now it has gained special importance because of the increasing threat from zoonoses. Zoonosis is defined as any infection naturally transmissible from vertebrate animals to humans. As the frequency and prevalence of zoonotic diseases increase worldwide, they become a real threat to public health. In addition, many of the newly discovered diseases have a zoonotic origin. Due to globalization and urbanization, some of these diseases have already spread all over the world, caused by the international flow of goods, people, and animals. However, special attention should be paid to farm animals since, apart from the direct contact, humans consume their products, such as meat, eggs, and milk. Therefore, zoonoses such as salmonellosis, campylobacteriosis, tuberculosis, swine and avian influenza, Q fever, brucellosis, Shiga-toxic Escherichia coli (STEC) infections, and listeriosis are crucial for both veterinary and human medicine. Consequently, in the suspicion of any zoonoses outbreak, the medical and veterinary services should closely cooperate to protect the public health. 
  • 595
  • 30 Jan 2022
Topic Review
Small Public Urban Green Spaces for Mental Restoration
Small public urban green space (SPUGS) was defined as urban public spaces which did not exceeding 5,000 m2 in size with vegetation and their own entrance. Exposure to SPUGS has been demonstrated to have mental benefits for older adults. However, studies on identifying the objective environmental features of SPUGS and their effects on mental restoration for older adults remain limited. The research results showed that: (1) Both the green view index, and the boundary enclosure had a strong impact on the mental restoration of older adults; (2) The colorfulness index showed the strongest relationship with the vitalizing effect. (3) Sky view factor and, number of seats only influenced the ROS score, while the results of revitalization suggest that large areas of water should be avoided. (4) Physiological Equivalent Temperature (PET) was also confirmed to have negative effects on the psychological health of seniors in autumn. 
  • 595
  • 20 May 2022
Topic Review
Mutual Regulatory Mechanisms between N6-metyladenosine Modification and miRNAs
N6-metyladenosine (m6A), one of the most common RNA methylation modifications in mammals, has attracted extensive attentions owing to its regulatory roles in a variety of physiological and pathological processes. As a reversible epigenetic modification on RNAs, m6A is dynamically mediated by the functional interplay among the regulatory proteins of methyltransferases, demethylases and methyl-binding proteins. It has become increasingly clear that m6A modification is associated with the production and function of microRNAs (miRNAs).
  • 593
  • 10 Feb 2023
Topic Review
Environmental Stressors and the PINE Network
Both psychosocial and physical environmental stressors have been linked to chronic mental health and chronic medical conditions. The psycho-immune-neuroendocrine (PINE) network details metabolomic pathways which are responsive to varied stressors and link chronic medical conditions with mental disorders, such as major depressive disorder via a network of pathophysiological pathways. Biological links have been established between particulate matter (PM) exposure, key sub-networks of the PINE model and mental health sequelae, suggesting that in theory, long-term mental health impacts of PM exposure may exist, driven by the disruption of these biological networks. This disruption could trans-generationally influence health; however, long-term studies and information on chronic outcomes following acute exposure event are still lacking, limiting what is known beyond the acute exposure and all-cause mortality. More empirical evidence is needed, especially to link long-term mental health sequelae to PM exposure, arising from PINE pathophysiology. 
  • 592
  • 20 Dec 2022
Topic Review
Walking Needs and COVID-19
More than 150 cities around the world have expanded emergency cycling and walking infrastructure to increase their resilience in the face of the COVID 19 pandemic. This tendency toward walking has led it to becoming the predominant daily mode of transport that also contributes to significant changes in the relationships between the hierarchy of walking needs and walking behaviour. These changes need to be addressed in order to increase the resilience of walking environments in the face of such a pandemic.
  • 591
  • 26 Jul 2021
Topic Review
Dissecting Polygenic Etiology of Ischemic Stroke
Ischemic stroke (IS), the leading cause of death and disability worldwide, is caused by many modifiable and non-modifiable risk factors. This complex disease is also known for its multiple etiologies with moderate heritability. Polygenic risk scores (PRSs), which have been used to establish a common genetic basis for IS, may contribute to IS risk stratification for disease/outcome prediction and personalized management. Statistical modeling and machine learning algorithms have contributed significantly to this field. For instance, multiple algorithms have been successfully applied to PRS construction and integration of genetic and non-genetic features for outcome prediction to aid in risk stratification for personalized management and prevention measures. PRS derived from variants with effect size estimated based on the summary statistics of a specific subtype shows a stronger association with the matched subtype. The disruption of the extracellular matrix and amyloidosis account for the pathogenesis of cerebral small vessel disease (CSVD). Pathway-specific PRS analyses confirm known and identify novel etiologies related to IS.
  • 591
  • 20 Oct 2022
Topic Review
Sexually Transmitted Infections (STIs)
Recent estimates of 8 common bacterial, viral, and parasitic sexually-transmitted infections in the United States (chlamydia, gonorrhea, trichomoniasis, syphilis, herpes simplex virus type 2, human papillomavirus, hepatitis B virus, and human immunodeficiency virus) found them to have a combined prevalence of 67.6 million and incidence of 26.2 million. Though preventative health guidelines have clarified screening recommendations for some populations, many bacterial sexually-transmitted infections (STIs) are asymptomatic, leading to missed opportunities for diagnosis and underreporting of disease prevalence and incidence. The best available estimates, published in early 2021, are from 2018. Overall, it is thought that 1 in 5 people in the United States has an STI, with 45.5% of all new STIs occurring in adolescents and young adults. New infections amount to $16 billion in direct medical costs.
  • 590
  • 24 Jan 2022
Topic Review
Physical Activity, Diet, Gut Microbiota
The human gut microbiota has been defined as the entire collection of microbes (bacteria, archaea, eukarya, and viruses) living as a complex ecosystem in our gastrointestinal tract, coevolved with humankind. Diet have a fundamental role in determining gut microbiota composition and diversity. 
  • 587
  • 16 Jun 2021
Topic Review
SIDS, Pulmonary Edema, and Sodium Toxicity
Sudden Infant Death Syndrome (SIDS) occurs unexpectedly in an otherwise healthy infant with no identifiable cause of death following a thorough investigation. A general hypervolemic state has been identified in SIDS, and fluid in the lungs suggests the involvement of pulmonary edema and hypoxia as the cause of death.
  • 584
  • 14 Mar 2024
Topic Review
Climate-Resilient and Climate-Neutral City
The urban heat island (UHI) effect is the main problem regarding a city’s climate. It is the main adverse effect of urbanization and negatively affects human thermal comfort levels as defined by physiological equivalent temperature (PET) in the urban environment. Blue and green infrastructure (BGI) solutions may mitigate the UHI effect. First, however, it is necessary to understand the problem from the degrading side. Researchers related to urban planning, architecture, and climatology are developing the city-UHI relationship’s mechanics and effective mitigation strategies based on the already-known dependencies. What the future urban environment should look like in order to be resilient to climate change and to be climate neutral are examined here.
  • 582
  • 12 Apr 2022
Topic Review
Measles Incidence and Eradication
Measles is an RNA virus infectious disease mainly seen in children. Despite the availability of an effective vaccine against measles, it remains a health issue in children. Although it is a self-limiting disease, it becomes severe in undernourished and immune-compromised individuals. Measles infection is associated with secondary infections by opportunistic bacteria due to the immunosuppressive effects of the measles virus. 
  • 579
  • 01 Sep 2022
Topic Review
Evaluation of Urban Cooling Interventions
Heat islands and warming temperatures are a growing global public health concern. Cities worldwide are implementing heat adaptation and mitigation interventions to reduce the urban heat island effect and extreme heat exposures. As listed by the Environmental Protection Agency (USA EPA), these interventions may include: trees/vegetation, green and cool roofs, cool pavements, and broadly improved infrastructure that invests in ‘greener’ practices. Although cities are implementing cooling interventions, little is known about their efficacy. Four interventions often used in urban areas are taken into consideration here: cooling centers, misting stations, cool (or green) roofs, and cool pavements.
  • 578
  • 01 Aug 2022
Topic Review
Sense of Coherence and Well-Being in Care Professionals
Job-related stress affects the physical and psychological health of professionals dedicated to care, and consequently affects the effectiveness of the entities for which they work. It is important to determine the relationships between a sense of coherence (SOC) and work stress and well-being perceived by care professionals. 
  • 578
  • 17 Oct 2023
Topic Review
Uncontrolled and Controlled Destruction of Acetylene Pressure Cylinders
The risk of physical destruction of a pressure cylinder increases with increasing temperature load. Acetylene is a significant hazardous gas in cylinders. If the destruction pressure is reached, the cylinder is torn into two or more pieces, followed by the gas release to the environment. The presence of ignition sources could lead to the formation of the fireball phenomenon. This phenomenon generally reaches approximately ten meters in diameter and can be accompanied by a blast wave and a spread of the cylinder’s fragments or surrounding objects. The consequences of this type of fire could be fatal. Shooting through the cylinder shell may lead to the mitigation, if not elimination, of the effects of the uncontrolled destruction mentioned above. As a result of the review of relevant publications, several states commonly use this method as a standard procedure. Internal gas is released through the resulting hole, the pressure drops down and the gas creates a fire jet or disperses to surroundings. This study is based on a large-scale experiment where acetylene cylinders were placed inside a prepared woodpile and exposed to fire. In the fire condition, the cylinders exploded and created fireballs, or were penetrated via shooting and created fire jets.
  • 576
  • 27 May 2022
Topic Review
Vaccine versus Variants
With the emergence and spread of new SARS-CoV-2 variants, concerns are raised about the effectiveness of the existing vaccines to protect against these new variants. Although many vaccines were found to be highly effective against the reference COVID-19 strain, the same level of protection may not be found against mutation strains. 
  • 575
  • 17 Nov 2021
Topic Review
Talar Fractures
Talar fractures are associated with relatively poor postoperative outcomes, high rates of AVN, and posttraumatic osteoarthritis. Poor outcomes revealed a positive association with fracture severity. Prospective studies investigating predictors for treatment success and/or failure are urgently needed to improve the overall quality of life and function of patients undergoing surgical treatment due to talar fractures.
  • 573
  • 11 Aug 2021
Topic Review
Link between Food Environment and Colorectal Cancer
Food and diet are critical risk factors for colorectal cancer (CRC). Food environments (FEs) can contribute to disease risk, including CRC. CRC incidence was associated with the availability of specific foods such as red meat, meat, animal fats, energy from animal sources, and an unhealthy FE. Increased CRC mortality was linked with the availability of animal fat, red meat, alcoholic beverages, and calorie food availability, residence in food deserts, and lower FE index. There were a variety of associations between CRC and the FE. The availability of specific foods, unhealthy FE, and food desserts impact CRC incidence and mortality.
  • 573
  • 30 Sep 2022
Topic Review
Neighbourhood Socioeconomic Processes and Dynamics and Healthy Ageing
Elderly citizens are concentrated in urban areas and are particularly affected by the immediate residential environment. Cities are unequal and segregated places, where there is an intensification of urban change processes such as gentrification and displacement. Since older adults spend most of their time in their nearby neighbourhood environment due to physical, emotional, and financial reasons, it is essential to understand how the neighbourhood environment affects this population's health. 
  • 571
  • 10 Jun 2022
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