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Topic Review
Complications Associated with Oblique Lumbar Interbody Fusion
The main advantage of Oblique Lumbar Interbody Fusion (OLIF) is its ability to provide safe access to the lumbar spine while being a robust interbody fusion technique through a minimally invasive approach. The rate of major complications after OLIF is minimal, making it a safe procedure with significant benefits outweighing the risks. The advantages of OLIF L2-5 with posterior stabilisation over stand-alone OLIF L2-5 is a subject of discussion.
  • 230
  • 22 Dec 2023
Topic Review
IGF-1/PI3K/AKT/FOXO3 Axis in Sarcopenia
The high prevalence of sarcopenia in an aging population has an underestimated impact on quality of life by increasing the risk of falls and subsequent hospitalization. Unfortunately, the application of the major established key therapeutic—physical activity—is challenging in the immobile and injured sarcopenic patient. Consequently, novel therapeutic directions are needed. The transcription factor Forkhead-Box-Protein O3 (FOXO3) may be an option, as it and its targets have been observed to be more highly expressed in sarcopenic muscle.
  • 221
  • 20 Dec 2023
Topic Review
Novel Technologies in the Assessment of Patellofemoral Pain
Patellofemoral pain (PFP) is a common clinical condition especially in the young active population. It refers to pain during activities behind or around the patella and has a gradual onset with increased frequency or duration. The literature for PFP reports concerns for the high incidence, prevalence numbers, disability levels, and poor prognosis. 
  • 220
  • 13 Nov 2023
Topic Review
Biofeedback in Patellofemoral Pain Conservative Treatment
atellofemoral pain syndrome is typical of active young adults, manifesting as retro patellar or peripatellar pain. It usually begins slowly and progresses with a gradual increase in pain. Often atraumatic, it has been linked to increased weight bearing on the patellofemoral joint.
  • 198
  • 04 Mar 2024
Topic Review
Lateral Lumbar Interbody Fusion
Lumbar interbody fusion procedures have seen a significant evolution over the years, with various approaches being developed to address spinal pathologies and instability, including posterior lumbar interbody fusion (PLIF), transforaminal lumbar interbody fusion (TLIF), anterior lumbar interbody fusion (ALIF), and lateral lumbar interbody fusion (LLIF). LLIF, a pivotal technique in the field, initially emerged as extreme/direct lateral interbody fusion (XLIF/DLIF) before the development of oblique lumbar interbody fusion (OLIF). To ensure comprehensive circumferential stability, LLIF procedures are often combined with posterior stabilization (PS) using pedicle screws. 
  • 198
  • 05 Mar 2024
Topic Review
Chondroitin Sulphate Based Nanoparticle Production
Joint damage is a major symptom of osteoarthritis, a degenerative disease that worsens over time. Due to its poor regenerative and self-healing properties, cartilage repair after lesions or debilitating disease is a major clinical issue.
  • 183
  • 08 Jan 2024
Topic Review
3D Printing in Hip Surgery
Three-dimensional printing, also known as additive manufacturing, is the process of creating objects from a 3D digital model layer by layer. Its origin dates back to 1984, when Chuck Hall developed his patent “Apparatus for production of three-dimensional objects by stereolithography”. There are many surgical applications of 3D printing in hip surgery, most of them based on CT images. 
  • 179
  • 04 Feb 2024
Topic Review
3D-Printed Porous Titanium Alloy Pore Structure onBone Regeneration
As a biomedical material, porous titanium alloy has gained widespread recognition and application within the field of orthopedics. Its remarkable biocompatibility, bioactivity, and mechanical properties establish it as a promising material for facilitating bone regeneration. A well-designed porous structure can lower the material’s modulus while retaining ample strength, rendering it more akin to natural bone tissue. The repair and replacement of a wide range of bone defects caused by diseases, trauma, and aging has been an important subject for centuries.
  • 148
  • 28 Feb 2024
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