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Topic Review
Platelet-Rich Plasma Treatment for Spinal Diseases
Spinal diseases are commonly associated with pain and neurological symptoms, which negatively impact patients’ quality of life. Platelet-rich plasma (PRP) is an autologous source of multiple growth factors and cytokines, with the potential to promote tissue regeneration. PRP has been widely used for the treatment of musculoskeletal diseases, including spinal diseases, in clinics.
  • 501
  • 03 Jul 2023
Topic Review
Collagen and the Knee’s Structural Integrity
Collagens represent the predominant protein class in mammals, accounting for approximately 30% of the total protein mass and serving as a fundamental component of the extracellular matrix (ECM).
  • 500
  • 07 Feb 2024
Topic Review
Complications Associated with Oblique Lumbar Interbody Fusion
The main advantage of Oblique Lumbar Interbody Fusion (OLIF) is its ability to provide safe access to the lumbar spine while being a robust interbody fusion technique through a minimally invasive approach. The rate of major complications after OLIF is minimal, making it a safe procedure with significant benefits outweighing the risks. The advantages of OLIF L2-5 with posterior stabilisation over stand-alone OLIF L2-5 is a subject of discussion.
  • 492
  • 22 Dec 2023
Topic Review
Lateral Lumbar Interbody Fusion
Lumbar interbody fusion procedures have seen a significant evolution over the years, with various approaches being developed to address spinal pathologies and instability, including posterior lumbar interbody fusion (PLIF), transforaminal lumbar interbody fusion (TLIF), anterior lumbar interbody fusion (ALIF), and lateral lumbar interbody fusion (LLIF). LLIF, a pivotal technique in the field, initially emerged as extreme/direct lateral interbody fusion (XLIF/DLIF) before the development of oblique lumbar interbody fusion (OLIF). To ensure comprehensive circumferential stability, LLIF procedures are often combined with posterior stabilization (PS) using pedicle screws. 
  • 485
  • 05 Mar 2024
Topic Review
Chondroitin Sulphate Based Nanoparticle Production
Joint damage is a major symptom of osteoarthritis, a degenerative disease that worsens over time. Due to its poor regenerative and self-healing properties, cartilage repair after lesions or debilitating disease is a major clinical issue.
  • 478
  • 08 Jan 2024
Topic Review
Platelet Gel on Reconstructing Bone Defects and Nonunions
In ideal circumstances, a fractured bone can heal properly by itself or with the aid of clinical interventions. However, around 5% to 10% of bone fractures fail to heal properly within the expected time even with the aid of clinical interventions, resulting in nonunions. Platelet gel is a blood-derived biomaterial used in regenerative medicine aiming to promote wound healing and regeneration of damaged tissues. Most of the studies applied the combination of platelet gel and bone graft to reconstruct bone defects and nonunions, and most of the results were positive, suggesting that this treatment strategy could promote successful reconstruction of bone defects and nonunions. In conclusion, the application of platelet gel could be a promising and useful treatment method for reconstructing bone defects and nonunions, and more future clinical studies are encouraged to further investigate the effectiveness of this promising treatment method.
  • 476
  • 17 Oct 2022
Topic Review
Novel Technologies in the Assessment of Patellofemoral Pain
Patellofemoral pain (PFP) is a common clinical condition especially in the young active population. It refers to pain during activities behind or around the patella and has a gradual onset with increased frequency or duration. The literature for PFP reports concerns for the high incidence, prevalence numbers, disability levels, and poor prognosis. 
  • 393
  • 13 Nov 2023
Topic Review
3D-Printed Porous Titanium Alloy Pore Structure onBone Regeneration
As a biomedical material, porous titanium alloy has gained widespread recognition and application within the field of orthopedics. Its remarkable biocompatibility, bioactivity, and mechanical properties establish it as a promising material for facilitating bone regeneration. A well-designed porous structure can lower the material’s modulus while retaining ample strength, rendering it more akin to natural bone tissue. The repair and replacement of a wide range of bone defects caused by diseases, trauma, and aging has been an important subject for centuries.
  • 357
  • 28 Feb 2024
Topic Review
Cosmetic Limb Lengthening
Cosmetic limb lengthening is a surgical intervention aimed at increasing height in individuals without medical indications such as deformity or discrepancy. Unlike reconstructive lengthening procedures performed for congenital or acquired conditions, cosmetic interventions are undertaken primarily to address dissatisfaction with stature, self-image, and psychosocial challenges.
  • 321
  • 18 Aug 2025
Topic Review
Graft Failure after Quadriceps Tendon Autograft ACL Reconstruction
Anterior cruciate ligament reconstruction (ACLR) is the recommended treatment in young and active patients to avoid such secondary damage to other knee structures.Whereas still most surgeons prefer hamstring tendon (HT) autografts, quadriceps tendon (QT) autografts have become increasingly popular even for primary ACLR during the recent years. Recently, numerous studies have shown the beneficial aspects of vancomycin by drastically reducing or even eliminating the risk of postoperative septic arthritis after ACLR. In the present case series, we present a series of ten patients after undergoing ACLR by using a QT autograft with vancomycin soaking and developing early graft failure due to graft resorption (within 12 months) after the index operation. We then discuss the current literature and possible factors associated with this phenomenon.
  • 314
  • 14 Feb 2025
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