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Topic Review
Novel 1,2,4-Oxadiazole Derivatives
Five-membered 1,2,4-oxadiazole heterocyclic ring has received considerable attention because of its unique bioisosteric properties and an unusually wide spectrum of biological activities. Thus, it is a perfect framework for the novel drug development. After a century since the 1,2,4-oxadiazole have been discovered, the uncommon potential attracted medicinal chemists’ attention, leading to the discovery of a few presently accessible drugs containing 1,2,4-oxadiazole unit. It is worth noting that the interest in a 1,2,4-oxadiazoles’ biological application has been doubled in the last fifteen years. Herein, after a concise historical introduction, we present a comprehensive overview of the recent achievements in the synthesis of 1,2,4-oxadiazole-based compounds and the major advances in their biological applications in the period of the last five years as well as brief remarks on prospects for further development.
  • 6.5K
  • 03 Jun 2021
Topic Review
Geotourism
Geotourism is a form of nature tourism that provides a more immersive experience by exploring the geological richness of the destination. In their natural form or explored as thermal springs and spas, landscape elements and geological formations offer visitors a richer and more holistic experience.
  • 6.5K
  • 06 Jan 2022
Topic Review
PC5-Based Cellular-V2X Evolution and Deployment
C-V2X (Cellular Vehicle-to-Everything) is a state-of-the-art wireless technology used in autonomous driving and intelligent transportation systems (ITS). 
  • 6.5K
  • 19 Feb 2021
Topic Review
Constituent State
A constituent state is a state entity that constitutes a part of a sovereign state. A constituent state holds regional jurisdiction over a defined administrative territory, within a sovereign state. Government of a constituent state is a form of regional government. Throughout history, and also in modern political practice, most constituent states are part of complex states, like federations or confederations. Constituent states can have republican or monarchical forms of government. Those of republican form are usually called states or autonomous states, republics or autonomous republics, or cantons. Those that have a monarchical form of government are often defined by traditional hierarchical rank of their ruler (usually a principality, or an emirate).
  • 6.5K
  • 31 Oct 2022
Topic Review
Interactive Movie
An interactive movie, also known as a movie game, is a video game that presents its gameplay in a cinematic, scripted manner, often through the use of full-motion video of either animated or live-action footage. In modern times, the term also refers to games that have a larger emphasis on story/presentation than on gameplay, often used in a pejorative way.
  • 6.5K
  • 04 Nov 2022
Topic Review
Internet of Things
The Internet of Things (IoT) refers to a system of interrelated, internet-connected objects that are able to collect and transfer data over a wireless network without human intervention. The term IoT has been considered as an expanding technique applied in various applications and functions, from smart environments and houses to personal healthcare and others [1]. It is described as a smart concept for the internet relating everything to the Internet and data organization and information exchange [2]. The key features required for employing a large-scale IoT are low-cost sensors, highspeed and error-tolerant data communications, smart computations, and numerous applications.
  • 6.5K
  • 26 Oct 2020
Topic Review
Amino Acid Catabolism
Amino acids have been extensively studied in nutrition, mainly as key elements for maintaining optimal protein synthesis in the body as well as precursors of various nitrogen-containing compounds. However, it is now known that amino acid catabolism is an important element for the metabolic control of different biological processes, although it is still a developing field to have a deeper understanding of its biological implications. The mechanisms involved in the regulation of amino acid catabolism now include the contribution of the gut microbiota to amino acid oxidation and metabolite generation in the intestine, the molecular mechanisms of transcriptional control, and the participation of specific miRNAs involved in the regulation of amino acid degrading enzymes. In addition, molecules derived from amino acid catabolism play a role in metabolism as they are used in the epigenetic regulation of many genes.
  • 6.5K
  • 02 Aug 2023
Topic Review
Role of Granulosa and Theca Cells in PCOS
Polycystic ovary syndrome (PCOS) is the most common heterogeneous endocrine disorder among women of reproductive age. The pathogenesis of PCOS remains elusive and there is evidence suggesting the potential contribution of genetic interactions or predispositions combined with environmental factors.
  • 6.5K
  • 16 Jan 2023
Topic Review
Rehabilitation Robots
Rehabilitation is the process of treating post-stroke consequences. Impaired limbs are considered the common outcomes of stroke, which require a professional therapist to rehabilitate the impaired limbs and restore fully or partially its function. Due to the shortage in the number of therapists and other considerations, researchers have been working on developing robots that have the ability to perform the rehabilitation process. During the last two decades, different robots were invented to help in rehabilitation procedures. This paper explains the types of rehabilitation treatments and robot classifications. In addition, a few examples of well-known rehabilitation robots will be explained in terms of their efficiency and controlling mechanisms
  • 6.5K
  • 03 Nov 2020
Topic Review
Single Cell Protein Production Using Different Fruit Waste
The single cell protein (SCP) refers to the dead, dried microbial cells or total protein extracted from the pure microbial culture of algae, bacteria, filamentous fungi, unicellular algae, and cyanobacteria cultivated on different carbon sources that are used as a protein supplement in human foods or animal feeds. Many studies reported that the wastes from various fruits such as orange, sweet orange, mango, banana, pomegranate, pineapple, grapes, watermelon, papaya, and many others are potential substrates for SCP production. These SCPs can be used as a protein supplement in human foods or animal feeds. 
  • 6.5K
  • 28 Jul 2022
Topic Review
Teachers’ Role during the COVID-19 Pandemic
A teacher’s professional role embodies a multitude of implications. Generally, its meaning has improved through professional experience over time. The concept of a teacher’s professional role is dynamic and is formed and reformed through time. The teacher’s professional role is indispensable to education. Without the professional role of teachers, school activities are difficult to be carried out effectively.
  • 6.5K
  • 17 Feb 2022
Topic Review
Personality Test
A personality test is a method of assessing human personality constructs. Most personality assessment instruments (despite being loosely referred to as "personality tests") are in fact introspective (i.e., subjective) self-report questionnaire (Q-data, in terms of LOTS data) measures or reports from life records (L-data) such as rating scales. Attempts to construct actual performance tests of personality have been very limited even though Raymond Cattell with his colleague Frank Warburton compiled a list of over 2000 separate objective tests that could be used in constructing objective personality tests. One exception however, was the Objective-Analytic Test Battery, a performance test designed to quantitatively measure 10 factor-analytically discerned personality trait dimensions. A major problem with both L-data and Q-data methods is that because of item transparency, rating scales and self-report questionnaires are highly susceptible to motivational and response distortion ranging all the way from lack of adequate self-insight (or biased perceptions of others) to downright dissimulation (faking good/faking bad) depending on the reason/motivation for the assessment being undertaken. The first personality assessment measures were developed in the 1920s and were intended to ease the process of personnel selection, particularly in the armed forces. Since these early efforts, a wide variety of personality scales and questionnaires have been developed, including the Minnesota Multiphasic Personality Inventory (MMPI), the Sixteen Personality Factor Questionnaire (16PF), the Comrey Personality Scales (CPS), among many others. Although popular especially among personnel consultants, the Myers–Briggs Type Indicator (MBTI) has numerous psychometric deficiencies. More recently, a number of instruments based on the Five Factor Model of personality have been constructed such as the Revised NEO Personality Inventory. However, the Big Five and related Five Factor Model have been challenged for accounting for less than two-thirds of the known trait variance in the normal personality sphere alone. Estimates of how much the personality assessment industry in the US is worth range anywhere from $2 and $4 billion a year (as of 2013). Personality assessment is used in wide a range of contexts, including individual and relationship counseling, clinical psychology, forensic psychology, school psychology, career counseling, employment testing, occupational health and safety and customer relationship management.
  • 6.5K
  • 13 Oct 2022
Topic Review
Utopia
A utopia (/juːˈtoʊpiə/ yoo-TOH-pee-ə) is an imaginary community or society that possesses highly desirable or nearly perfect qualities for its citizens. The term was coined by Sir Thomas More for his 1516 book Utopia, describing a fictional island society in the south Atlantic Ocean off the coast of South America. The opposite of a utopia is a dystopia, which dominates the fictional literature from the 1950s onwards, chiefly because of the impact of George Orwell's Nineteen Eighty-Four, published in 1949. However, the term can also denote actual experiments in what participants regard as a vastly superior manner of living, generally in what are termed intentional communities. In common parlance it is synonymous with "impossible", "far-fetched", and "deluded". Literary utopias focus on, amongst other things, equality, in such categories as economics, government and justice, with the method and structure of proposed implementation varying based on ideology. Lyman Tower Sargent argues that the nature of a utopia is inherently contradictory because societies are not homogeneous and have desires which conflict and therefore cannot simultaneously be satisfied. According to Sargent:
  • 6.5K
  • 08 Nov 2022
Topic Review
List of Translations of the Paschal Greeting
This article lists translations of the Christian Paschal greeting in various languages.
  • 6.5K
  • 23 Nov 2022
Topic Review
Ynglism
Ynglism (Russian: Инглии́зм, also spelled "Yngliism" or "Inglyism"), institutionally the Ancient Russian Ynglistic Church of the Orthodox Old Believers—Ynglings (Древнерусская Инглиистическая Церковь Православных Староверов—Инглингов, Drevnerusskaya Ingliisticheskaya Tserkov' Pravoslavnykh Staroverov—Inglingov) is a direction of the Slavic Native Faith movement registered with the Ministry of justice of the Russian Federation in the early 1990s by Aleksandr Khinevich from Omsk, in Siberia.({{{1}}}, {{{2}}}) Adepts call themselves "Old Believers-Ynglings", seldom simply "Ynglings". The church is described by scholar Kaarina Aitamurto as having a well-defined doctrine, an authoritative leadership, and focusing on esoteric teachings.({{{1}}}, {{{2}}}) Ynglings regard themselves as perserving the true, orthodox (i.e. in accordance with the universal order), religious tradition of the Russians and of all the Slavs. Rodnover groups in Russia are strongly critical of Ynglism; the international veche (assembly) of Rodnover organisations even declared it a false religion. In the early 2000s the church faced judicial prosecutions for ethnic hatred, and Khinevich himself was imprisoned from 2009 to 2011. The central writings of Ynglism are the four Slavic-Aryan Vedas.
  • 6.5K
  • 25 Nov 2022
Topic Review
9K111 Fagot
The 9K111 Fagot (Russian: Фагот; "bassoon") is a second-generation tube-launched SACLOS wire-guided anti-tank missile system of the Soviet Union for use from ground or vehicle mounts. The 9K111 Fagot missile system was developed by the Tula KBP Design Bureau for Instrument Building. "9M111" is the GRAU designation of the missile. Its NATO reporting name is AT-4 Spigot.
  • 6.5K
  • 21 Oct 2022
Topic Review
6G-IoT Technologies
The advent of 6G-IoT promises a revolutionary leap, integrating AI, expanded coverage, and autonomy in a seamless manner, thereby reshaping industries such as smart agriculture. Presented here are the essential technologies that will make it possible to meet the 6G-IoT requirements.
  • 6.5K
  • 07 Aug 2023
Topic Review
Digital Literacy
Digital literacy refers to an individual's ability to find, evaluate, and compose clear information through writing and other media on various digital platforms. Digital literacy is evaluated by an individual's grammar, composition, typing skills and ability to produce text, images, audio and designs using technology. While digital literacy initially focused on digital skills and stand-alone computers, the advent of the internet and use of social media, has caused some of its focus to shift to mobile devices. Similar to other expanding definitions of literacy that recognize cultural and historical ways of making meaning, digital literacy does not replace traditional forms of literacy, and instead builds upon and expands the skills that form the foundation of traditional forms of literacy. Digital literacy should be considered to be a part of the path to knowledge. Digital literacy is built on the expanding role of social science research in the field of literacy as well as on concepts of visual literacy, computer literacy, and information literacy. Overall, digital literacy shares many defining principles with other fields that use modifiers in front of literacy to define ways of being and domain specific knowledge or competence. The term has grown in popularity in education and higher education settings and is used in both international and national standards.
  • 6.5K
  • 31 Oct 2022
Topic Review
Mac OS Memory Management
Historically, the classic Mac OS used a form of memory management that has fallen out of favor in modern systems. Criticism of this approach was one of the key areas addressed by the change to Mac OS X. The original problem for the engineers of the Macintosh was how to make optimum use of the 128 KB of RAM with which the machine was equipped, on Motorola 68000-based computer hardware that did not support virtual memory. Since at that time the machine could only run one application program at a time, and there was no fixed secondary storage, the engineers implemented a simple scheme which worked well with those particular constraints. That design choice did not scale well with the development of the machine, creating various difficulties for both programmers and users.
  • 6.5K
  • 15 Nov 2022
Topic Review
16S rRNA Next-Generation Sequencing
The 16S rRNA gene is highly conserved in all bacteria (and also archaea). Nonetheless, it contains nine hypervariable regions (V1 - V9), where sequences of these regions can be used to identify and discriminate bacterial genus, sometimes until the species level. This makes the gene a useful tool for phylogenetic studies. With the introduction of next-generation sequencing technologies, 16S rRNA next-generation sequencing (16SNGS) has allowed profiling of bacterial communities found in organisms and the environment, and lead to the discovery of many previously unculturable members of the bacteria kingdom.
  • 6.5K
  • 18 May 2021
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