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Topic Review
Human Stem Cell Transplantation for Retinal Degenerative Diseases
Irreversible visual impairment is mainly caused by retinal degenerative diseases such as age-related macular degeneration and retinitis pigmentosa. Stem cell research has experienced rapid progress in recent years, and researchers and clinical ophthalmologists are trying to implement this promising technology to treat retinal degeneration. There is currently no surgical or pharmacological solution to regenerate an injured or degenerative retina, and the only approach ophthalmologists can take is to slow the progress of the loss of vision. In the last decade, many efforts have been made to take advantage of the promising properties of the stem cell technology and apply them to retinal degenerative diseases.
  • 997
  • 08 Feb 2022
Topic Review
YAP and TAZ Mediators
Cell reprogramming can either refer to a direct conversion of a specialized cell into another or to a reversal of a somatic cell into an induced pluripotent stem cell (iPSC). It implies a peculiar modification of the epigenetic asset and gene regulatory networks needed for a new cell, to better fit the new phenotype of the incoming cell type. Cellular reprogramming also implies a metabolic rearrangement, similar to that observed upon tumorigenesis, with a transition from oxidative phosphorylation to aerobic glycolysis. The induction of a reprogramming process requires a nexus of signaling pathways, mixing a range of local and systemic information, and accumulating evidence points to the crucial role exerted by the Hippo pathway components Yes-Associated Protein (YAP) and Transcriptional Co-activator with PDZ-binding Motif (TAZ).
  • 987
  • 28 May 2021
Topic Review
Dynamic Environment in Organ-on-a-Chip Platforms
Organ-on-a-chip (OOC) uses the microfluidic 3D cell culture principle to reproduce organ- or tissue-level functionality at a small scale instead of replicating the entire human organ. This provides an alternative to animal models for drug development and environmental toxicology screening. In addition to the biomimetic 3D microarchitecture and cell–cell interactions, it has been demonstrated that mechanical stimuli such as shear stress and mechanical strain significantly influence cell behavior and their response to pharmaceuticals. Microfluidics is capable of precisely manipulating the fluid of a microenvironment within a 3D cell culture platform. As a result, many OOC prototypes leverage microfluidic technology to reproduce the mechanically dynamic microenvironment on-chip and achieve enhanced in vitro functional organ models. Unlike shear stress that can be readily generated and precisely controlled using commercial pumping systems, dynamic systems for generating proper levels of mechanical strains are more complicated, and often require miniaturization and specialized designs.
  • 987
  • 15 Jul 2021
Topic Review
The Role of Biomaterials in Optic Neuropathies
Hereditary optic neuropathies (HONs) such as dominant optic atrophy (DOA) and Leber Hereditary Optic Neuropathy (LHON) are mitochondrial diseases characterized by a degenerative loss of retinal ganglion cells (RGCs) and are a cause of blindness worldwide. To date, there are only limited disease-modifying treatments for these disorders. The discovery of induced pluripotent stem cell (iPSC) technology has opened several promising opportunities in the field of HON research and the search for therapeutic approaches. 
  • 986
  • 15 Apr 2024
Topic Review
Rare Genetic Diseases
Rare diseases are conditions that affect a small proportion of the population (fewer than 200,000 persons in the USA or fewer than one in 2000 in Europe). The Orphanet portal for rare diseases and orphan drugs (http://www.orpha.net, accessed on 15 September 2021) currently lists more than 5800 rare diseases. Many are genetically inherited and the genetic causes are clearly identified. From the beginning of the human PSC history, rare genetic disorders have been attractive models for proof-of-concept studies of disease modelling. hESC derived from embryos after pre-implantation genetic diagnosis were a first source of Human pluripotent stem cells (PSCs) with natural, disease-inducing mutations.
  • 985
  • 07 Dec 2021
Topic Review
Applications about Single-Cell Printing
Single-cell analysis has become a powerful and indispensable tool in modern biological and medical research. Single-cell isolation is the key step for single-cell analysis. Single-cell printing could utilize various microfluidic technologies for single-cell isolation and analysis, such as droplet microfluidics, microwell arrays, and hydrodynamic traps. Single-cell printing shows several distinct advantages among the single-cell isolation techniques, such as precise deposition, high encapsulation efficiency, and easy recovery. With the development of single-cell printing in the past decade, various single-cell printing-based single-cell analyses and applications have been performed, ranging from single-cell array-based screening and single-cell-based mass spectroscopy to live three-dimensional tissue formation.
  • 985
  • 11 Feb 2022
Topic Review
Mechanotransduction in Mesenchymal Stem Cells Differentiation
Mechanotransduction is the process by which physical force is converted into a biochemical signal that is used in development and physiology; meanwhile, it is intended for the ability of cells to sense and respond to mechanical forces by activating intracellular signals transduction pathways and the relative phenotypic adaptation. Mesenchymal stem cells (MSCs) are potent mediators of cardiac repair which can secret a large array of soluble factors that have been shown to play a huge role in tissue repair. Differentiation of MSCs is required to regulate mechanical factors such as fluid shear stress, mechanical strain, and the rigidity of the extracellular matrix through various signaling pathways for their use in regenerative medicine.
  • 984
  • 11 May 2022
Topic Review
Mesenchymal Stem Cells Studies in the Goat Model
Stem cells can be classified as embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), and mesenchymal stem cells (MSCs), which differ in origin, plasticity, differentiation potential, and risk of tumorigenesis. MSCs have been the most studied cells, with excellent and safe results in multiple areas. In the area of tissue engineering and regenerative medicine, the caprine model is particularly used in studies using stem cells in the musculoskeletal system but, although in a more limited way, also in the field of dermatology, ophthalmology, dentistry, pneumology, cardiology, and urology.
  • 983
  • 26 Sep 2022
Topic Review
Intraocular Ienses
Intraocular lenses (IOLs) are tiny artificial devices placed inside the eye, which have the main function of restoring the refractive power of the natural crystalline lens that is removed during cataract surgery. 
  • 982
  • 02 Mar 2023
Topic Review
Chronic Diabetic Wounds
With the global prevalence of type 2 diabetes mellitus steeply rising, instances of chronic, hard-healing, or non-healing diabetic wounds and ulcers are predicted to increase. The growing understanding of healing and regenerative mechanisms has elucidated critical regulators of this process, including key cellular and humoral components. Despite this, the management and successful treatment of diabetic wounds represents a significant therapeutic challenge. 
  • 980
  • 07 Apr 2021
Topic Review
Chimeric Antigen Receptor T-Cell Therapy
The treatment landscape for hematologic malignancies has changed since the recent approval of highly effective CAR-T. Chimeric antigen receptor T-cell therapy (CAR-T) is a type of immunotherapy in which a patient’s T cells are collected and genetically engineered to improve their ability to recognize and kill cancer cells. However, several issues are still unsolved and represent the challenges for the coming years. The lack of initial responses and early relapse are some hurdles to be tackled. Moreover, new strategies are needed to increase the safety profile or shorten the manufacturing process during CAR-T cells therapy production. Finally, the clinical experience with CAR-T cells for solid tumors has been less encouraging, and development in this setting is desirable.
  • 980
  • 23 Nov 2022
Topic Review
Induced Nephron Progenitor-like Cells from Human Urine-Derived Cells
Chronic kidney disease (CKD) has emerged as a major public health concern due to its prevalence in 7–12% of the population worldwide, progression to irreversible end-stage renal disease (ESRD), impaired quality of life, associations with high social and financial costs, and high rates of associated morbidity and mortality (an 82% increase in CKD epidemic over the past two decades). The current treatment options for kidney failure involve lifelong dialysis and whole kidney transplantation. Although kidney transplantation undoubtedly offers a better quality of life and life expectancy than dialytic treatment, it is limited by the scarcity of available organs and the huge gap between supply and demand. Furthermore, considering that the average life expectancy of dialysis patients is barely a decade, alternative strategies for preventing or delaying the progression to ESRD are urgently needed. In this context, regenerative medicine strategies employing nephron progenitor cells (NPCs) are a viable approach that is worthy of substantial consideration as a promising cell source for kidney diseases. However, the generation of induced nephron progenitor-like cells (iNPCs) from human somatic cells remains a major challenge.
  • 975
  • 24 Dec 2021
Topic Review
Interdisciplinary Work on Human Liver Physiology
The knowledge accumulated about liver regeneration has allowed a better understanding of normal liver physiology, by reconstructing the sequence of steps that this organ follows when it must rebuild itself after being injured. The scientific community has used several interdisciplinary approaches searching to improve liver regeneration and, therefore, human health.
  • 970
  • 09 Dec 2022
Topic Review
The Application of Electrospun Nanofibers in Wound Dressings
Electrospun nanofiber membranes (NFMs) have high porosity and a large specific surface area, which provide a suitable environment for the complex and dynamic wound healing process and a large number of sites for carrying wound healing factors. The design of the nanofiber structure can imitate the structure of the human dermis, similar to the natural extracellular matrix, which better promotes the hemostasis, anti-inflammatory and healing of wounds. 
  • 963
  • 06 Sep 2023
Topic Review
Cell Therapy for Neurological Disorders
Neurological disorders are big public health challenges that are afflicting hundreds of millions of people around the world. Although many conventional pharmacological therapies have been tested in patients, their therapeutic efficacies to alleviate their symptoms and slow down the course of the diseases are usually limited. Cell therapy has attracted the interest of many researchers in the last several decades and has brought new hope for treating neurological disorders. Moreover, numerous studies have shown promising results. 
  • 960
  • 11 Jan 2022
Topic Review
Nanofibrous Scaffolds for Diabetic Wound Healing
Nanofibrous scaffolds are artificial extracellular matrices that mimic the natural environment for tissue formation. This type of scaffold is more advantageous than other available variants because of its large surface-to-volume ratio, which leads to the efficient promotion of cell adhesion, proliferation, and differentiation. 
  • 960
  • 30 Mar 2023
Topic Review
Tumor-Derived Exosomes in Preparing the Pre-metastatic Niche
Tumor-derived exosomes play a multifaceted role in preparing the pre-metastatic niche, promoting cancer dissemination, and regulating cancer cell dormancy. Tumor-derived exosomes are small vesicles that are released by tumor cells and contain a variety of molecules, including proteins, lipids and nucleic acids. They play a key role in cancer progression and metastasis by modulating the tumor microenvironment, promoting cancer cell survival and growth, and communicating with nearby cells. As such, these exosomes can act as vehicles for delivering pro-tumorigenic information and signals, helping to propagate cancer in the body.
  • 949
  • 14 Jun 2023
Topic Review
Ageing and Inflammation in Periodontium
Periodontitis is a ubiquitous chronic inflammatory disease characterized by the gradual destruction of the periodontal ligament and alveolar bone, leading to periodontal pocket formation and gingival recession. Ageing is a primary risk factor for the development of periodontitis, exacerbating alveolar bone loss and leading to tooth loss in the geriatric population.
  • 943
  • 24 Nov 2023
Topic Review
MSC-EVs in Osteoporosis
Osteoporosis (OP) is a chronic bone disease characterized by decreased bone mass, destroyed bone microstructure, and increased bone fragility. Accumulative evidence shows that extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) (MSC-EVs), especially exosomes (Exos), exhibit great potential in the treatment of OP.
  • 941
  • 23 Dec 2022
Topic Review
Small-Diameter Tissue-Engineered Vascular Grafts
In general, arterial bypass grafting in the heart or below the knee requires small-diameter grafts. Thus, shortage of material for such surgeries remains a big challenge because autologous grafts are often not available in certain patient groups such as claudicants, patients with diabetics or vein disease, and in patients requiring reoperations. This has further underscored the need for developing alternative small-diameter vascular grafts. One candidate, small-diameter tissue-engineered vascular grafts (SD-TEVGs), is fabricated using novel techniques and interdisciplinary knowledge including material, engineering, and cell biology. Advantages of using SD-TEVGs as compared to autografts, include noninvasive surgery during preparation of grafts, unlimited availability, and customized dimension.
  • 938
  • 13 Apr 2021
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