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Marie-Anne Libert, (born 7 April 1782 in Malmedy, province of Liège, died 14 January 1865 in Malmedy) was a Belgian botanist and mycologist. She was one of the first women plant pathologists. She is sometimes referred to as "Anne-Marie Libert."

551
08 Oct 2022

Topic Review

Ecosystem-Based Adaptation

Ecosystem-based adaptation (EbA) encompasses a broad set of approaches to adapt to climate change. They all involve the management of ecosystems and their services to reduce the vulnerability of human communities to the impacts of climate change. The Convention on Biological Diversity defines EbA as "the use of biodiversity and ecosystem services as part of an overall adaptation strategy to help people to adapt to the adverse effects of climate change". EbA involves the conservation, sustainable management and restoration of ecosystems, such as forests, grasslands, wetlands, mangroves or coral reefs to reduce the harmful impacts of climate hazards including shifting patterns or levels of rainfall, changes in maximum and minimum temperatures, stronger storms, and increasingly variable climatic conditions. EbA measures can be implemented on their own or in combination with engineered approaches (such as the construction of water reservoirs or dykes), hybrid measures (such as artificial reefs) and approaches that strengthen the capacities of individuals and institutions to address climate risks (such as the introduction of early warning systems). EbA is nested within the broader concept of nature-based solutions and complements and shares common elements with a wide variety of other approaches to building the resilience of social-ecological systems. These approaches include community-based adaptation, ecosystem-based disaster risk reduction, climate-smart agriculture, and green infrastructure, and often place emphasis on using participatory and inclusive processes and community/stakeholder engagement. The concept of EbA has been promoted through international fora, including the processes of the United Nations Framework Convention on Climate Change (UNFCCC) and the Convention on Biological Diversity (CBD). A number of countries make explicit references to EbA in their strategies for adaptation to climate change and their Nationally Determined Contributions (NDCs) under the Paris Agreement. While the barriers to widespread uptake of EbA by public and private sector stakeholders and decision makers are substantial, cooperation toward generating a greater understanding of the potential of EbA is well established among researchers, advocates, and practitioners from nature conservation and sustainable development groups. EbA is increasingly viewed as an effective means of addressing the linked challenges of climate change and poverty in developing countries, where many people are dependent on natural resources for their lives and livelihoods.

547
15 Nov 2022

Topic Review

Antagonistic Coevolution

Sexual antagonistic co-evolution is the relationship between males and females where sexual morphology changes over time to counteract the opposite's sex traits to achieve the maximum reproductive success. This has been compared to an arms race between sexes. In many cases, male mating behavior is detrimental to the female's fitness. For example, when insects reproduce by means of traumatic insemination, it is very disadvantageous to the female's health. During mating, males will try to inseminate as many females as possible, however, the more times a female's abdomen is punctured, the less likely she is to survive. Females that possess traits to avoid multiple matings will be more likely to survive, resulting in a change in morphology. In males, genitalia is relatively simple and more likely to vary among generations compared to female genitalia. This results in a new trait that females have to avoid in order to survive. Additionally, sexual antagonistic co-evolution can be the cause of rapid evolution, as is thought to be the case in seminal proteins known as Acps in species of Drosophila melanogaster. While Acps facilitate the mutually beneficial outcome of increased progeny production, several Acps have detrimental effects on female fitness as they are toxic and shorten her lifespan. This leads to antagonistic co-evolution, as the female must evolve in order to defend herself. When female Drosophila melanogaster are experimentally prevented from co-evolving with males, males rapidly adapt to the static female phenotype. This male adaptation leads to a reduction in female survivorship, which is mediated by an increased rate of remating and increased toxicity of Acps in seminal fluid. Since non-reproductive proteins do not feel the same evolutionary pressure as Acps, they are not evolving nearly as quickly. Consistent with the arms race theory, DNA analyses reveal a two-fold increase in Acp divergence relative to non-reproductive proteins

534
19 Oct 2022

Topic Review

Task Allocation and Partitioning of Social Insects

Task allocation and partitioning is the way that tasks are chosen, assigned, subdivided, and coordinated within a colony of social insects. Task allocation and partitioning gives rise to the division of labor often observed in social insect colonies, whereby individuals specialize on different tasks within the colony (e.g., "foragers", "nurses"). Communication is closely related to the ability to allocate tasks among individuals within a group. This entry focuses exclusively on social insects. For information on human task allocation and partitioning, see division of labour, task analysis, and workflow.

533
20 Oct 2022

Topic Review

Type A Influenza Vaccine

Type A influenza vaccine is for the prevention of infection of influenza A virus and also the influenza-related complications. Different monovalent type A influenza vaccines have been developed for different subtypes of influenza A virus including H1N1 and H5N1. Both intramuscular injection or intranasal spray are available on market. Unlike the seasonal influenza vaccines which are used annually, they are usually used during the outbreak of certain strand of subtypes of influenza A. Common adverse effects includes injection site reaction and local tenderness. Incidences of headache and myalgia were also reported with H1N1 whereas cases of fever has also been demonstrated with H5N1 vaccines. It is stated that immunosuppressant therapies would reduce the therapeutic effects of vaccines and that people with egg allergy should go for the egg-free preparations. There are different methods in developing the vaccines. Traditionally, inactivated viral vaccine and live attenuated virus vaccine have been approved. Inactivated viral vaccine is primary used parentally and the live attenuated vaccine is used intranasally. Development of new technologies including the recombinant hemagglutinin technology have widely been studied. Influenza A virus was successfully identified and isolated by Wilson Smith, Christopher Andrewes, and Patrick Laidlaw in the 1930s and the first inactivated monovalent influenza A vaccine was made after a decade. The first H5N1 vaccine was approved in 2007. It was intentionally developed to prepare for the possible H5N1 outbreak in the future. Moreover, in view of the H1N1 outbreak in 2009, H1N1 monovalent vaccines, targeting only H1N1 virus, was produced. Influenza A exists in many subtypes including H5N1, H1N1 and H3N2. Different formulations of monovalent vaccines have been developed over the years to cater different needs and antigens identified.

527
11 Oct 2022

Topic Review

Exosomes-Mediated Signaling Pathway for Organ Ischemia-Reperfusion Injury Treatment

Ischemia reperfusion (I/R) is a common pathological process which occurs mostly in organs like the heart, brain, kidney, and lung. The injury caused by I/R gradually becomes one of the main causes of fatal diseases, which is an urgent clinical problem to be solved. Although great progress has been made in therapeutic methods, including surgical, drug, gene therapy, and transplant therapy for I/R injury, the development of effective methods to cure the injury remains a worldwide challenge.

525
07 Feb 2024

Topic Review

Integrating Text-Mining into the Curation of Disease Maps

The interactive, user-friendly disease map viewer was developed to support the automated creation of systems medicine models such as disease maps by text mining. It sits at the interface between computational text mining and the manual expert creation of disease maps, was developed to sit at the interface between computational text mining and the manual expert creation and brings together the time-saving advantages of text mining with the accuracy of manual data curation.

495
20 Sep 2022

Topic Review

Biochemical Recurrence in High-Risk Localized Prostate Cancer

This retrospective study compared oncological outcomes in 107 patients with localized prostate cancer treated between 2016–2023 by either laparoscopic radical prostatectomy (LRP; n=61) or external beam radiotherapy with androgen deprivation therapy (EBRT+ADT; n=46). Median follow-up was 60 months for LRP and 66 months for EBRT. Biochemical recurrence (BCR) was defined as PSA > 0.2 ng/mL post-LRP or > 2 ng/mL above nadir post-EBRT. BCR occurred in 34.4% of LRP and 21.7% of EBRT patients. Five-year BCR-free survival was 65.6% (LRP) vs. 71.7% (EBRT), with a trend favoring EBRT (log-rank p = 0.089). Median time to recurrence was 30 months (LRP) and 48 months (EBRT). In the LRP group, higher ISUP grade (p = 0.001), advanced pathological stage (p < 0.001), positive surgical margins (p < 0.001), and intermediate PSA levels (10–20 ng/mL; p = 0.080) predicted BCR. No independent predictors were found in the EBRT group. Both treatments offered effective cancer control, but LRP had a higher recurrence risk, especially in patients with intermediate-risk features. These findings support risk-adapted follow-up and timely salvage therapy in high-risk LRP patients.

281
01 Jul 2025

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