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Topic Review
Dkk3/REIC Deficiency
The role of Dickkopf-3 (Dkk3)/REIC (The Reduced Expression in Immortalized Cells), a Wnt-signaling inhibitor, in male reproductive physiology remains unknown thus far.
  • 663
  • 17 Feb 2022
Topic Review
Pathogenesis of Radical-Prostatectomy-Associated Morbidity
The oncological goal of RP is to achieve a complete removal of the cancerous prostate tissue in order to cure the patient of PC. The surgical procedure involves removing the entire prostate, with its capsule intact, alongside the seminal vesicles and distal vas deferens, followed by vesico-urethral anastomosis.
  • 644
  • 28 Mar 2023
Topic Review
Obstructive and Non-Obstructive Azoospermia
Azoospermia (no sperm in ejaculate), a severe form of male infertility, affects around 1% of men globally. It may be caused by many factors, including blockage of the reproductive tract, hormonal disbalances, ejaculation problems or issues with spermatogenic epithelium or testicular function.
  • 585
  • 02 Aug 2023
Topic Review
Endocrine Changes Causing Infertility in Obese Males
Overweight and obesity are terms used to describe an abnormal and excessive build-up of body fat that may have a detrimental effect on health. Body mass index (BMI) is a measure of body weight per height that is widely used to classify adults as overweight or obese. It is calculated by dividing a person’s body weight (in kilograms) by the square of their height (in meters/m2). The World Health Organization (WHO) defines overweight as a BMI of 25 kg/m2 or above and obesity as a BMI of 30 kg/m2 or above. The rising incidence of obesity has coincided with rising levels of poor reproductive outcomes. The molecular basis for the association of infertility in obese males is now being explained through various mechanisms. Insulin resistance, hyperglycemia, and changes in serum and gonadal concentrations of adipokines, like leptin, adiponectin, resistin, and ghrelin have been implicated as causes of male infertility in obese males.
  • 393
  • 05 Jan 2024
Topic Review
Tex29 Is a Novel Acrosome Marker
TEX29 is a novel testis-specific acrosomal marker protein that is essential for maintaining the normal integrity of the acrosomal membrane during murine spermiogenesis. Despite this role, TEX29 is dispensable for spermatogenesis and fertilization in both mice and humans, likely due to genetic redundancy. 
  • 5
  • 01 Dec 2025
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