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Topic Review
Severe Falciparum Malaria
Plasmodium falciparum can cause a severe disease with high mortality. A major factor contributing to the increased virulence of P. falciparum, as compared to other human malarial parasites, is the sequestration of infected erythrocytes in the capillary beds of organs and tissues. This sequestration is due to the cytoadherence of infected erythrocytes to endothelial cells.
  • 886
  • 02 Aug 2023
Topic Review
Eumycetoma Medical Treatment
Mycetoma is a neglected tropical disease that is associated with poor communities and socioeconomically impaired individuals in the tropical and sub-tropical areas. Interestingly, the disease is caused by either bacteria (actinomycetoma) or fungus (eumycetoma). The latter form of the disease, eumycetoma, is the most common type in Africa. Eumycetoma is characterized by a prolonged disease duration and low cure rate. The effective case management of eumycetoma largely depends on the accurate diagnosis and identification of the causative agent to the species level and evaluating its susceptibility to the available drugs.
  • 865
  • 23 Mar 2022
Topic Review
Aetiology and Pathogenesis of Vitiligo
Vitiligo is an acquired, chronic condition characterised by depigmentation of the epidermis or by destruction/loss of melanin. Skin cells (melanocytes) are responsible for producing melanin, the substance that gives pigmentation to the skin. Although there is no specific ethnic group, gender, or skin type that is more prone to vitiligo than others, it can affect anyone. Even though vitiligo is typically thought of as a cosmetic disorder, its effects on the physical and psychosocial health of sufferers cannot be ignored.
  • 854
  • 09 Jun 2023
Topic Review
Control Strategies for Mosquito-Borne Diseases
Mosquito-borne diseases are spread by the bite of infected female mosquitoes. The main mosquito-borne diseases include malaria, Chikungunya, Zika, Dengue, West Nile, yellow fever, Rift Valley fever, Lymphatic filariasis, and tick-borne encephalitis. Various chemical, biological, and mechanical methods are used to control mosquito-borne diseases hence reducing their burden.
  • 745
  • 13 Mar 2023
Topic Review
Triazoles in Therapies for Parasitic Diseases
This entry provides a concise overview of the advancements and potential of triazole-based compounds in developing new treatments for major parasitic diseases, such as malaria, leishmaniasis, Chagas disease, and schistosomiasis. It also highlights their mechanisms of action, the application of advanced therapeutic strategies like nanomedicine and drug repurposing, and future perspectives in combating these globally prevalent infections.
  • 497
  • 29 May 2025
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