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Topic Review
Liquid Biopsy in Colorectal Cancer
There is a critical need for new diagnostic and prognostic biomarkers with high specificity and sensitivity in patients with colorectal cancer (CRC). Liquid biopsy could represent the new era for biomarkers detection: the term “liquid biopsy” refers to the isolation of cancer-derived components, such as circulating tumor cells (CTC), circulating tumor DNA (ctDNA), microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and proteins, from peripheral blood or other body fluids (i.e., ascites, urine, pleural effusion, and cerebrospinal fluid), and their genomic or proteomic assessment. Furthermore, exosomes (EXOs) which are membrane-bound extracellular vesicles containing proteins and nucleic acids released in the bloodstream by cancer cells, could represent potential biomarkers. 
  • 1.6K
  • 09 Nov 2020
Topic Review
Sexual Sadism Disorder
Sexual sadism disorder is the condition of experiencing sexual arousal in response to the extreme pain, suffering or humiliation of others. Several other terms have been used to describe the condition, and the condition may overlap with other conditions that involve inflicting pain. It is distinct from situations in which consenting individuals use mild or simulated pain or humiliation for sexual excitement. The words sadism and sadist are derived from Marquis de Sade.
  • 1.6K
  • 27 Sep 2022
Topic Review
Acute Stress Reaction
Acute stress reaction (also called acute stress disorder, psychological shock, mental shock, or simply shock) is a psychological condition arising in response to a terrifying or traumatic event, or witnessing a traumatic event that induces a strong emotional response within the individual. It should not be confused with the unrelated circulatory condition of shock/hypoperfusion. Acute stress reaction (ASR) may develop into delayed stress reaction (better known as Posttraumatic stress disorder, or PTSD) if stress is not correctly managed. ASR is characterized by re-living and avoiding reminders of an aversive event, as well as generalized hypervigilance after initial exposure to a traumatic event. ASR is differentiated from PTSD as a disorder that precedes it, and if symptoms last for more than one month, it will develop into PTSD. It can thus be thought of as the acute phase of PTSD.
  • 1.6K
  • 02 Dec 2022
Topic Review
Pathogenesis of COVID-19
The systemic manifestations commonly observed in COVID-19 patients include hypertension, arterial and venous thromboembolism, kidney disease, cerebrovascular disorders, and diabetes mellitus). These clinical findings strongly suggest that the virus is targeting the endothelium. Here we report a systematic and comprehensive evaluation of the evidence showing that the endothelium is a key target organ in COVID-19, playing a fundamental role in its pathogenesis.
  • 1.6K
  • 30 Oct 2020
Topic Review
Timeline of Tuberculosis
This is a timeline of tuberculosis, describing especially major discoveries, advances in treatment and major organizations.
  • 1.6K
  • 23 Nov 2022
Topic Review
Atypical Depression
Atypical depression as it has been known in the DSM IV, is depression that shares many of the typical symptoms of the psychiatric syndromes of major depression or dysthymia but is characterized by improved mood in response to positive events. In contrast to atypical depression, people with melancholic depression generally do not experience an improved mood in response to normally pleasurable events. Atypical depression also features significant weight gain or an increased appetite, hypersomnia, a heavy sensation in the limbs, and interpersonal rejection sensitivity that results in significant social or occupational impairment. Despite its name, "atypical" depression does not mean it is uncommon or unusual. The reason for its name is twofold: it was identified with its "unique" symptoms subsequent to the identification of melancholic depression and its responses to the two different classes of antidepressants that were available at the time were different from melancholic depression (i.e., MAOIs had clinically significant benefits for atypical depression, while tricyclics did not). Atypical depression is four times more common in females than in males. Individuals with atypical features tend to report an earlier age of onset (e.g. while in high school) of their depressive episodes, which also tend to be more chronic and only have partial remission between episodes. Younger individuals may be more likely to have atypical features, whereas older individuals may more often have episodes with melancholic features. Atypical depression has high comorbidity of anxiety disorders, carries more risk of suicidal behavior, and has distinct personality psychopathology and biological traits. Atypical depression is more common in individuals with bipolar I, bipolar II, cyclothymia and seasonal affective disorder. Depressive episodes in bipolar disorder tend to have atypical features, as does depression with seasonal patterns.
  • 1.6K
  • 02 Nov 2022
Topic Review
Drug Policy Reform
Drug policy reform, also known as drug law reform, generally refers to proposed changes to the laws and regulations that governments promulgate with respect to substances that have psychoactive effects or a real or perceived potential to be used for recreational or other non-medical reasons. Proponents of drug policy reform frequently argue that prohibition of recreational drugs—such as cannabis, opioids, cocaine, amphetamines and hallucinogens—has been ineffective and counterproductive and that substance use is better responded to by implementing practices for harm reduction and increasing the availability of addiction treatment. Another reform proposed is to introduce a regulatory regime for the production, marketing, and distribution of some or all currently illegal drugs in a manner analogous to that for alcohol and tobacco. Proponents of drug law reform argue that relative harm should be taken into account in the regulation of controlled substances. Addictive or dependence-forming substances such as alcohol, tobacco and caffeine have been a traditional part of many culture for centuries and remain legal in most countries, though other drugs which cause less harm than alcohol or tobacco are entirely prohibited, with possession punishable with severe criminal penalties.
  • 1.6K
  • 26 Oct 2022
Topic Review
Tuberculin
Tuberculin, also known as purified protein derivative, is a combination of proteins that are used in the diagnosis of tuberculosis. This use is referred to as the tuberculin skin test and is recommended only for those at high risk. Reliable administration of the skin test requires large amounts of training, supervision, and practice. Injection is done into the skin. After 48 to 72 hours, if there is more than a five to ten millimeter area of swelling, the test is considered positive. Common side effects include redness, itchiness, and pain at the site of injection. Allergic reactions may occasionally occur. The test may be falsely positive in those who have been previously vaccinated with BCG or have been infected by other types of mycobacteria. The test may be falsely negative within ten weeks of infection, in those less than six months old, and in those who have been infected for many years. Use is safe in pregnancy. Tuberculin was discovered in 1890 by Robert Koch. Koch, best known for his work on the etiology of tuberculosis (TB), laid down various rigorous guidelines that aided the establishment between a pathogen and the specific disease that followed that were later named Koch's postulates. Although he initially believed it would cure tuberculosis, this was later disproved. Tuberculin is made from an extract of Mycobacterium tuberculosis. It is on the World Health Organization's List of Essential Medicines.
  • 1.6K
  • 29 Sep 2022
Topic Review
Health Effects of Enterolignans
Enterolignans are metabolites generated by the gut flora from lignans. The later can derive from lignin and are present in numerous fruits, vegetables and grains. Among the gut metabolites are Enterolactone and Enterodiol which exhibit slight estrogenic and anti-estrogenic activities at nutritional levels of exposure. There is a great variability among humans for the synthesis of enterolignans since only specific gut bacteria can produce estrogenic enterolignans. Their health effects are essentially beneficial due to their low ingestion levels and their peculiar interactions with estrogen receptors.
  • 1.6K
  • 08 Feb 2023
Topic Review
Dengue and Chikungunya
Dengue and chikungunya are the vector-borne diseases, that are transmitted to humans by the mosquitoes Aedes aegypti and Aedes albopictus. This study aimed to show the spatial and temporal distribution of those diseases in the Hindu Kush Himalayan region.   
  • 1.6K
  • 27 Oct 2020
Topic Review
Adipose Tissue Macrophages in Obesity and Insulin Resistance
Obesity has become a worldwide epidemic that poses a severe threat to human health. Evidence suggests that many obesity comorbidities, such as type 2 diabetes mellitus, steatohepatitis, and cardiovascular diseases, are related to obesity-induced chronic low-grade inflammation. Macrophages are the primary immune cells involved in obesity-associated inflammation in both mice and humans. Intensive research has yielded tremendous progress in the understanding of the additional roles of adipose tissue macrophages (ATMs) beyond classical M1/M2 polarization in obesity and related comorbidities.
  • 1.6K
  • 01 Jul 2022
Topic Review
Morning Tiredness
Morning tiredness (also known as morning fatigue) is a feeling of prolonged tiredness experienced in the morning. It could be caused by a simple reason such as inadequate sleep, however it could also be a sign of an underlying health problem. There have been numerous scientific studies conducted on morning tiredness such as it's relationship with caffeine in children and its association with a person's particular characteristic such as their level of exercise. Morning tiredness is not to be confused with sleep inertia which is the short term drowsiness experienced immediately after waking up.
  • 1.6K
  • 26 Oct 2022
Topic Review
Sonodynamic Therapy
Sonodynamic therapy is an effective treatment for eliminating tumor cells by irradiating sonosentitizer in a patient’s body with higher penetration ultrasound and inducing the free radicals. Titanium dioxide has attracted the most attention due to its properties among many nanosensitizers. Hence, in this study, carbon doped titanium dioxide, one of inorganic materials, is applied to avoid the foregoing, and furthermore, carbon doped titanium dioxide is used to generate ROS under ultrasound irradiation to eliminate tumor cells. Spherical carbon doped titanium dioxide nanoparticles are synthesized by the sol-gel process. The forming of C-Ti-O bond may also induce defects in lattice which would be beneficial for the phenomenon of sonoluminescence to improve the e ectiveness of sonodynamic therapy. By dint of DCFDA, WST-1, LDH and the Live/Dead test, carbon doped titanium dioxide nanoparticles are shown to be a biocompatible material which may induce ROS radicals to suppress the proliferation of 4T1 breast cancer cells under ultrasound treatment. From in vivo study, carbon doped titanium dioxide nanoparticles activated by ultrasound may inhibit the growth of the 4T1 tumor, and it showed a significant di erence between sonodynamic therapy (SDT) and the other groups on the seventh day of the treatment.
  • 1.6K
  • 13 Apr 2021
Topic Review
Timeline of Leukemia
This is a timeline of leukemia, describing especially major discoveries and advances in treatment against the disease.
  • 1.6K
  • 07 Nov 2022
Topic Review
Medcyclopaedia
This is a list of medical wikis, collaboratively-editable websites that focus on medical information. Many of the most popular medical wikis take the form of encyclopedias, with a separate article for each medical term. Some of these websites, such as WikiDoc and Radiopaedia, are editable by anyone, while others, such as Ganfyd, restrict editing access to professionals. The majority of them have content available only in English. The largest and most popular general encyclopedia, Wikipedia, also hosts a significant amount of health and medical information.
  • 1.6K
  • 30 Nov 2022
Topic Review
Intravenous Immunoglobulins
Intravenous immunoglobulins (IVIG) are blood preparations pooled from the plasma of donors that have been first employed as replacement therapy in immunodeficiency. IVIG interact at multiple levels with the different components of the immune system and exert their activity against infections. Passive immunotherapy includes convalescent plasma from subjects who have recovered from infection, hyperimmune globulin formulations with a high titer of neutralizing antibodies, and monoclonal antibodies (mAbs). IVIG are used for the prevention and treatment of several infections, especially in immunocompromised patients, or in case of a poorly responsive immune system. The evolution of IVIG from a source of passive immunity to a powerful immunomodulatory/anti-inflammatory agent results in extensive applications in autoimmune diseases. IVIG composition depends on the antibodies of the donor population and the alterations of protein structure due to the processing of plasma.
  • 1.6K
  • 23 Feb 2021
Topic Review
Wood Antimicrobial Behavior Test Method
Some wood species have antimicrobial properties and a variety of methods are used to investigate them. For testing the effect of antimicrobial compounds, direct and indirect methods are used. Meanwhile, the survival of microbes is also tested on surfaces (or material in contact with microbes) to validate the safety of surfaces.
  • 1.6K
  • 29 Oct 2020
Topic Review
Conduct Disorder
Conduct disorder (CD) is a mental disorder diagnosed in childhood or adolescence that presents itself through a repetitive and persistent pattern of behavior that includes theft, lies, physical violence that may lead to destruction and wanton breaking of rules, in which the basic rights of others or major age-appropriate norms are violated. These behaviors are often referred to as "antisocial behaviors." It is often seen as the precursor to antisocial personality disorder, which is per definition not diagnosed until the individual is 18 years old. Conduct disorder may result from parental rejection and neglect and can be treated with family therapy, as well as behavioral modifications and pharmacotherapy. Conduct disorder is estimated to affect 51.1 million people globally as of 2013.
  • 1.6K
  • 14 Nov 2022
Topic Review
Clinical Trials Registry
A clinical trials registry is an official platform and catalog for registering a clinical trial. Some countries require clinical trials being conducted in that country to be registered; others do not require it, but often strongly encourage it. ClinicalTrials.gov, run by the United States National Library of Medicine (NLM) was the first online registry for clinical trials and is the largest and most widely used today. Clinical trials are conducted to allow safety and efficacy data to be collected for health interventions (e.g., drugs, diagnostics, devices, therapy protocols). The goal of a clinical trials registry is to provide increased transparency and access to clinical trials, made available to the public. Clinical trials registries are often searchable (for example, trials can be searchable by disease/indication, drug, location, etc.). Trials are registered by the pharmaceutical, biotech or medical device company (Sponsor) or by the hospital or foundation which is sponsoring the study, or by another organization, such as a contract research organization (CRO) which is running the study. There has been a push from governments and international organizations, especially since 2005, to make clinical trial information more widely available and to standardize registries and processes of registering. The World Health Organization is working toward "achieving consensus on both the minimal and the optimal operating standards for trial registration".
  • 1.6K
  • 02 Nov 2022
Topic Review
Sexological Testing
Sexuality can be inscribed in a multidimensional model comprising different aspects of human life: biology, reproduction, culture, entertainment, relationships and love. In the last decades, a growing interest towards sexuality and a greater quest to acknowledge a "right to sexuality" has occurred both in society and individuals. The consequence of this evolution has been a renewed and more explicit call for intervention from those who suffer, or think they suffer from alterations of their sexual and relational sphere. This has produced an increased attention of medicine and psychology towards sexual dysfunctions and the problems they cause in individuals and couples. Science has gradually adjusted already existing research tools, mostly used in other fields of clinical research, to the field of sexology, so completing and increasing the number of tools in the "toolkit" of various branches of sexological diagnosis. Psychological measurements cannot be considered as accurate as physical ones (weight, height, mass, etc.), as the former evaluate those aspects and variables pertaining to an "individual" whose individuality refers to his/her own psychological, personological and environmental constituents: emotions, expressiveness, senses, feelings and experiences which can greatly vary according to the subjects and change in the short period or depending on different settings, even in the same individual. What is expected of psychological measurements is "sufficient" accuracy and reliability, i.e. capability to express an indication or focus which clinicians can use as a "guideline" to rapidly and accurately deepen the aspects highlighted by the measurements and check them together with their patients. For this purpose, several statistical validation indexes of psychodiagnostic tests are provided: from standardization to various constructions of validity (internal, external, face, construct, convergent, content, discriminant, etc.). There are several sexual dysfunctions and each of them has a different cause. Therefore, the field of sexology provides different psychological evaluation devices in order to examine the various aspects of the discomfort, problem or dysfunction, regardless of whether they are individual or relational ones. The number of psychodiagnostic reactives is certainly wide and heterogeneous, nevertheless, the number of tests specifically meant for the field of sexology is quite limited. The following list (in alphabetical order) is not exhaustive but shows the best known and/or most used reactives in the field of sexological and relational psychodiagnosis.
  • 1.6K
  • 17 Nov 2022
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