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Topic Review
Aloysia Citrodora Essential Oil
Patients diagnosed with melanoma have a poor prognosis due to regional invasion and metastases. The receptor tyrosine kinase epidermal growth factor receptor (EGFR) is found in a subtype of melanoma with a poor prognosis and contributes to drug resistance. Aloysia citrodora essential oil (ALOC-EO) possesses an antitumor effect. Understanding signaling pathways that contribute to the antitumor of ALOC-EO is important to identify novel tumor types that can be targeted by ALOC-EO. 
  • 702
  • 20 Aug 2021
Topic Review
Transcription–Replication Coordination
Transcription and replication are the two most essential processes that a cell does with its DNA: they allow cells to express the genomic content that is required for their functions and to create a perfect copy of this genomic information to pass on to the daughter cells. Nevertheless, these two processes are in a constant ambivalent relationship. When transcription and replication occupy the same regions, there is the possibility of conflicts between transcription and replication as transcription can impair DNA replication progression leading to increased DNA damage. Nevertheless, DNA replication origins are preferentially located in open chromatin next to actively transcribed regions, meaning that the possibility of conflicts is potentially an accepted incident for cells. Data in the literature point both towards the existence or not of coordination between these two processes to avoid the danger of collisions.
  • 702
  • 27 Jan 2022
Topic Review
ITGA2B Gene
Integrin subunit alpha 2b
  • 702
  • 23 Dec 2020
Topic Review
ANO5 Gene
anoctamin 5
  • 702
  • 24 Dec 2020
Topic Review
LMNB1 Gene
Lamin B1
  • 701
  • 23 Dec 2020
Topic Review
Nonketotic Hyperglycinemia
Nonketotic hyperglycinemia is a disorder characterized by abnormally high levels of a molecule called glycine in the body (hyperglycinemia). The excess glycine builds up in tissues and organs, particularly the brain. Affected individuals have serious neurological problems.
  • 701
  • 24 Dec 2020
Topic Review
Beta-Ketothiolase Deficiency
Beta-ketothiolase deficiency is an inherited disorder in which the body cannot effectively process a protein building block (amino acid) called isoleucine. This disorder also impairs the body's ability to process ketones, which are molecules produced during the breakdown of fats.
  • 701
  • 24 Dec 2020
Topic Review
KANK2 Gene
KN motif and ankyrin repeat domains 2
  • 700
  • 23 Dec 2020
Topic Review
STK11 Gene
Serine/threonine kinase 11: The STK11 gene (also called LKB1) provides instructions for making an enzyme called serine/threonine kinase 11.
  • 700
  • 24 Dec 2020
Topic Review
HLA-B Gene
Major histocompatibility complex, class I, B
  • 699
  • 22 Dec 2020
Topic Review
HNF1A Gene
HNF1 homeobox A
  • 699
  • 23 Dec 2020
Topic Review
CLCNKA Gene
chloride voltage-gated channel Ka
  • 699
  • 24 Dec 2020
Topic Review
RFX5 Gene
regulatory factor X5
  • 699
  • 24 Dec 2020
Topic Review
PURA Gene
purine rich element binding protein A
  • 698
  • 23 Dec 2020
Topic Review
CLN10 Disease
CLN10 disease is a severe disorder that primarily affects the nervous system. Individuals with this condition typically show signs and symptoms soon after birth. These signs and symptoms can include muscle rigidity, respiratory failure, and prolonged episodes of seizure activity that last several minutes (status epilepticus). It is likely that some affected individuals also have seizures before birth while in the womb. Infants with CLN10 disease have unusually small heads (microcephaly) with brains that may be less than half the normal size. There is a loss of brain cells in areas that coordinate movement (the cerebellum) and control thinking and emotions (the cerebral cortex). Nerve cells in the brain also lack a fatty substance called myelin, which protects them and promotes efficient transmission of nerve impulses. Infants with CLN10 disease often die hours to weeks after birth.
  • 698
  • 24 Dec 2020
Topic Review
Microbiota-Induced Epigenetic Alterations in Depressive Disorders
Major depressive disorder (MDD) is a complex disorder and a leading cause of disability in 280 million people worldwide. Many environmental factors, such as microbes, drugs, and diet, are involved in the pathogenesis of depressive disorders.
  • 698
  • 09 Jan 2024
Topic Review
ANKH Gene
ANKH inorganic pyrophosphate transport regulator
  • 697
  • 24 Dec 2020
Topic Review
CACNA1D Gene
calcium voltage-gated channel subunit alpha1 D
  • 697
  • 24 Dec 2020
Topic Review
Multiple Epiphyseal Dysplasia
Multiple epiphyseal dysplasia is a disorder of cartilage and bone development primarily affecting the ends of the long bones in the arms and legs (epiphyses). There are two types of multiple epiphyseal dysplasia, which can be distinguished by their pattern of inheritance. Both the dominant and recessive types have relatively mild signs and symptoms, including joint pain that most commonly affects the hips and knees, early-onset arthritis, and a waddling walk. Although some people with multiple epiphyseal dysplasia have mild short stature as adults, most are of normal height. The majority of individuals are diagnosed during childhood; however, some mild cases may not be diagnosed until adulthood.
  • 697
  • 23 Dec 2020
Topic Review
COL11A1 Gene
collagen type XI alpha 1 chain
  • 697
  • 24 Dec 2020
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