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Topic Review
Glucose Monitoring
Glucose monitoring is essential to control diabetes and avoid long-term complications. Diabetics suffer on a daily basis with the traditional glucose monitors currently in use, which are invasive, painful, and cost-intensive. Therefore, the demand for non-invasive, painless, economical, and reliable approaches to monitor glucose levels is increasing.
  • 1.4K
  • 30 Oct 2021
Topic Review
Fall Risk Assessment Using Wearable Sensors
Fall risk assessment based on wearable sensors can be performed from a long-term perspective, in which sensor data is used to predict subject’s long-term fall risk based on clinical scale scores, or from a short-term approach, where data collected is used to detect pre-fall/unbalanced situations in real-time and consequently identify fall risk events.
  • 1.4K
  • 24 Feb 2022
Topic Review
Visual pH Sensors
The pH sensors are gaining widespread attention as non-destructive tools, visible to the human eye, and are capable of real-time and in-situ response.
  • 1.4K
  • 31 May 2021
Topic Review
Bone-Conducted Ultrasound
Bone-conducted ultrasound (BCU) has unique characteristics since ultrasound is audible when it is presented through bone conduction. The most interesting is its perception in patients with profound deafness. Some patients can perceive it and discriminate speech-modulated BCU. Previous reports have suggested that BCU can be used for a hearing aid or tinnitus sound therapy.
  • 1.4K
  • 09 Jun 2021
Topic Review
Detecting VOC Biomarkers in the Exhaled Breath
In general, volatile organic compounds (VOCs) have a high vapor pressure at room temperature (RT). It has been reported that all humans generate unique VOC profiles in their exhaled breath which can be utilized as biomarkers to diagnose disease conditions. The aforementioned discussions show that the human breath contains a variety of VOCs that serve as biomarkers for various diseases and metabolic problems. Therefore, the real-time monitoring of such VOCs in the exhaled human breath is highly essential to enable non-invasive illness detection. A detailed discussion has been carried out to understand various techniques developed to detect VOCs in very low concentrations of part per million volumes (ppmv), part per billion volumes (ppbv), and part per trillion volumes (pptv).
  • 1.4K
  • 09 Feb 2023
Topic Review
Chemical Gas Sensors
Nowadays, there is increasing interest in fast, accurate, and highly sensitive smart gas sensors with excellent selectivity boosted by the high demand for environmental safety and healthcare applications. Significant research has been conducted to develop sensors based on novel highly sensitive and selective materials. However, there are still great challenges, specifically in terms of selectivity, which raises the need for combining interdisciplinary fields to build smarter and high-performance gas/chemical sensing devices. This review is divided into two parts: In the first part, we cover the recent developments and limitations of chemresistive gas sensors and in the second part, machine learning is proposed as a potential approach to efficiently tackle these issues through pattern recognition algorithms.
  • 1.3K
  • 27 Apr 2021
Topic Review
Engineering Drug Delivery Systems
Engineering drug delivery systems (DDS) aim to release bioactive cargo to a specific site within the human body safely and efficiently. Hydrogels have been used as delivery matrices in different studies due to their biocompatibility, biodegradability, and versatility in biomedical purposes. Microparticles have also been used as drug delivery systems for similar reasons. The combination of microparticles and hydrogels in a composite system has been the topic of many research works. These composite systems can be injected in loco as DDS. The hydrogel will serve as a barrier to protect the particles and retard the release of any bioactive cargo within the particles. Additionally, these systems allow different release profiles, where different loads can be released sequentially, thus allowing a synergistic treatment. The reported advantages from several studies of these systems can be of great use in biomedicine for the development of more effective DDS.
  • 1.3K
  • 04 Oct 2021
Topic Review
Antisense Peptide Technology
Antisense peptide technology (APT) is based on a useful heuristic algorithm for rational peptide design. It was deduced from empirical observations that peptides consisting of complementary (sense and antisense) amino acids interact with higher probability and affinity than the randomly selected ones. This phenomenon is closely related to the structure of the standard genetic code table, and at the same time, is unrelated to the direction of its codon sequence translation.
  • 1.3K
  • 11 Oct 2021
Topic Review
Optical Properties of Mn-Doped CuGa(In)S-ZnS Nanocrystals (NCs)
Mn-doped binary NCs have average fluorescence lifetimes in the range of sub-milliseconds and/or need high energy for excitation, or they contain the toxic elements of Cd and/or Se against biosensing/imaging applications.
  • 1.3K
  • 11 Apr 2022
Topic Review
Wet Nanotechnology
Wet nanotechnology (also known as wet nanotech) involves working up to large masses from small ones. Wet nanotechnology requires water in which the process occurs. The process also involves chemists and biologists trying to reach larger scales by putting together individual molecules. While Eric Drexler put forth the idea of nano-assemblers working dry, wet nanotech appears to be the likely first area in which something like a nano-assembler may achieve economic results. Pharmaceuticals and bioscience are central features of most nanotech start-ups. Richard A.L. Jones calls nanotechnology that steals bits of natural nanotechnology and puts them in a synthetic structure biokleptic nanotechnology. He calls building with synthetic materials according to nature's design principles biomimetic nanotechnology. Using these guiding principles could lead to trillions of nanotech robots, that resemble bacteria in structural properties, entering a person's blood stream to do medical treatments.
  • 1.3K
  • 29 Sep 2022
Topic Review
Stimuli-Responsive Hydrogels in Drug Delivery
Stimuli-responsive hydrogels, also known as smart hydrogels, exhibit responsiveness to diverse external stimuli. These gels can undergo reversible or irreversible changes in physical or chemical properties upon exposure to stimuli, enabling a highly controllable drug release pattern. This capability contributes to achieving precise drug administration and enhancing treatment effectiveness and safety.
  • 1.3K
  • 24 Oct 2023
Topic Review
Digital Twins for Home Remote Motor Rehabilitation
The COVID-19 pandemic created the need for telerehabilitation development, while Industry 4.0 brought the key technology. As motor therapy often requires the physical support of a patient’s motion, combining robot-aided workouts with remote control is a promising solution. This may be realised with the use of the device’s digital twin so as to give it an immersive operation. Such technology may be used for manual remote kinesiotherapy, combined with the safety systems predicting potentially harmful situations. The concept is universally applicable to rehabilitation robots.
  • 1.3K
  • 18 Jan 2023
Topic Review
Smartphone-Based Biosensor Devices for Healthcare
Electrochemical biosensors are undoubtedly the most popular among POC devices due to their high sensitivity, simplicity, low cost, and reliability. The development of these electrochemical devices has continued to grow exponentially since Clark designed the first enzymatic glucose biosensor, which was then improved and became the most commercialized healthcare biosensor. Electrochemical biosensors that use smartphones received great attention as they use a friendly semi-automated user interface with minimum extra tailored hardware. They can also be used at home, offering an interesting, cost-effective alternative.
  • 1.3K
  • 11 Mar 2022
Topic Review
Hyperlipidemic Rabbit Models
Hyperlipidemia is a major risk factor for atherosclerotic diseases. Experimental animals play an important role in elucidating the molecular mechanisms of the pathophysiology of hyperlipidemia as well as in drug development. Rabbits are one of the most suitable models to study human hyperlipidemia because many features of the lipoprotein metabolism of rabbits are similar to those of humans. Currently, three types of rabbit models are commonly used for studying hyperlipidemia: (1) diet-induced hyperlipidemic rabbits, (2) spontaneous hyperlipidemic rabbits, and (3) gene-manipulated rabbits (transgenic and knockout rabbits).
  • 1.3K
  • 07 Jan 2021
Topic Review
Neuroprotection and Non-Invasive Brain Stimulation
Non-Invasive Brain Stimulation (NIBS) techniques, such as transcranial Direct Current Stimulation (tDCS) and repetitive Magnetic Transcranial Stimulation (rTMS), are well-known non-pharmacological approaches to improve both motor and non-motor symptoms in patients with neurodegenerative disorders. Their use is of particular interest especially for the treatment of cognitive impairment in Alzheimer’s Disease (AD), as well as axial disturbances in Parkinson’s (PD), where conventional pharmacological therapies show very mild and short-lasting effects. However, their ability to interfere with disease progression over time is not well understood; recent evidence suggests that NIBS may have a neuroprotective effect, thus slowing disease progression and modulating the aggregation state of pathological proteins. 
  • 1.3K
  • 23 Nov 2022
Topic Review
Fe0-based environmental remediation
The technology of using metallic iron (Fe0) for in situ generation of iron oxides for water treatment is a very old one. The Fe0 remediation technology has been re-discovered in the framework of groundwater remediation using permeable reactive barriers (PRBs). Despite its simplicity, the improvement of Fe0 PRBs is fraught with difficulties regarding their operating modes. The literature dealing with Fe0 remediation contains ambiguities regarding its invention and its development. The present paper examines the sequence of contributions prior to the advent of Fe0 PRBs in order to clarify the seemingly complex picture.
  • 1.3K
  • 26 Aug 2020
Topic Review
Endoscopy Lifetime Systems Architecture
Systems engineering captures the desires and needs of the customer to conceptualize a system from the overall goal down to the small details prior to any physical development. While many systems projects tend to be large and complicated (i.e., cloud-based infrastructure, long-term space travel shuttles, missile defense systems), systems engineering can also be applied to smaller, complex systems. The system of interest is the endoscope, a standard biomedical screening device used in laparoscopic surgery, screening of upper and lower gastrointestinal tracts, and inspection of the upper airway.
  • 1.3K
  • 25 Oct 2022
Topic Review
Advances in Non-Invasive Neuromodulation: Closed-Loop Vagus Nerve Stimulation
Transcutaneous auricular vagus nerve stimulation (taVNS) is a non-invasive neuromodulation therapy that eliminates the need for internal device implantation, presenting as a favorable therapeutic option. This method relies on electrical surface stimulation, bypassing the need for surgical procedures.
  • 1.3K
  • 18 Jan 2024
Topic Review
BAW-Based Separation
Bulk acoustic waves have been applied to microfluidic separations with many benefits, such as flexible placement of transducer, simple, and versatile setups. A BAW-based microfluidic device typically operates with bulk acoustic standing waves in a microchannel between two parallel opposite walls. BAW-based microfluidic separation techniques have been applied in separating various types of particles and biological samples based on their size, density and compressibility.
  • 1.3K
  • 26 Oct 2020
Topic Review
Geometrical Design of Lattices in Additive Manufacturing
Additive manufacturing (AM, also known as 3D printing) is an advanced manufacturing technique that has enabled progress in the design and fabrication of customised or patient-specific (meta-)biomaterials and biomedical devices (e.g., implants, prosthetics, and orthotics) with complex internal microstructures and tuneable properties. Several design guidelines have been proposed for creating porous lattice structures, particularly for biomedical applications.
  • 1.3K
  • 25 Aug 2022
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