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Peng, Y. Recombinant Antigens. Encyclopedia. Available online: https://encyclopedia.pub/entry/61462 (accessed on 12 November 2026).
Peng Y. Recombinant Antigens. Encyclopedia. Available at: https://encyclopedia.pub/entry/61462. Accessed November 12, 2026.
Peng, Yu. "Recombinant Antigens" Encyclopedia, https://encyclopedia.pub/entry/61462 (accessed November 12, 2026).
Peng, Y. (2026, October 25). Recombinant Antigens. In Encyclopedia. https://encyclopedia.pub/entry/61462
Peng, Yu. "Recombinant Antigens." Encyclopedia. Web. 25 October, 2026.
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Recombinant Antigens
EditRecombinant antigens are antigenic proteins or protein-derived constructs produced through expression of engineered genetic sequences. Their molecular identity includes the encoded amino-acid sequence and any structural or chemical features introduced during biosynthesis. Glycosylation can contribute directly to recognized epitopes or influence the folding and accessibility of antigenic surfaces [1]. Recombinant expression can generate a selected antigenic protein as part of a larger fusion polypeptide [2]. The spatial arrangement of exposed residues establishes conformational epitopes recognized by antibodies, making folding and structural integrity integral properties of the expressed antigen [3]. Genetic fusion can also join an antigenic sequence to another protein domain within a single translation product [4].
recombinant antigens
protein expression
antigenic determinants
protein conformation
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References
- Maddy L. Newby; Joel D. Allen; Max Crispin; Influence of glycosylation on the immunogenicity and antigenicity of viral immunogens. Biotechnol. Adv. 2023, 70, 108283. [CrossRef]
- Dennis G. Kleid; Daniel Yansura; Barbara Small; Donald Dowbenko; Douglas M. Moore; Marvin J. Grubman; Peter D. McKercher; Donald O. Morgan; Betty H. Robertson; Howard L. Bachrach; Cloned Viral Protein Vaccine for Foot-and-Mouth Disease: Responses in Cattle and Swine. Science 1981, 214, 1125-1129. [CrossRef]
- Philip R. Dormitzer; Jeffrey B. Ulmer; Rino Rappuoli; Structure-based antigen design: a strategy for next generation vaccines. Trends Biotechnol. 2008, 26, 659-667. [CrossRef]
- Peter Michael Moyle; Biotechnology approaches to produce potent, self-adjuvanting antigen-adjuvant fusion protein subunit vaccines. Biotechnol. Adv. 2017, 35, 375-389. [CrossRef]
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Biochemistry & Molecular Biology
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